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anti-Mouse (Murine) IL2RG antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended IL2RG Antibody (supplied by: Log in to see )

Antigen
Interleukin 2 Receptor, gamma (IL2RG) Antibodies
  • Ab2-183
  • CD132
  • Cd132
  • CIDX
  • gamma(c)
  • gc
  • IL-2RG
  • IMD4
  • P64
  • SCIDX
  • SCIDX1
  • [g]c
Epitope
AA 135-185
16
12
10
9
8
7
6
5
5
4
4
4
2
2
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
95
48
24
2
Host
Rabbit
83
27
9
Clonality
Polyclonal
Conjugate
This IL2RG antibody is un-conjugated
12
9
9
5
4
3
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
59
45
36
10
10
4
4
2
2
1
1
1
1
Supplier
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Catalog No. ABIN2176981
$ 269.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008982679 ABIN1859417 ICC IHC (fro) IHC (p) ELISA WB Rabbit IgG AA 23-263 Log in to see Polyclonal
0.0008982679 ABIN2176986 IHC (p) WB Biotin Rabbit IgG AA 135-185 Log in to see Polyclonal
0.0008982679 ABIN2176992 IHC (p) WB HRP Rabbit IgG AA 135-185 Log in to see Polyclonal

Similar anti-IL2RG Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine) Human
ELISA 7 Antibodies 11 Antibodies 39 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies 11 Antibodies
Immunohistochemistry (IHC) 6 Antibodies 6 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 3 Antibodies 4 Antibodies
Western Blotting (WB) 10 Antibodies 14 Antibodies
Blocking Reagent (BR) 1 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies 1 Antibodies
Flow Cytometry (FACS) 13 Antibodies
Immunocytochemistry (ICC) 1 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies
Intracellular Flow Cytometry (ICFC) 1 Antibodies
Neutralization (Neut) 3 Antibodies

General

Antigen Interleukin 2 Receptor, gamma (IL2RG) Antibodies
Epitope AA 135-185
(16), (12), (10), (9), (8), (7), (6), (5), (5), (4), (4), (4), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(95), (48), (24), (2)
Host Rabbit
(83), (27), (9)
Clonality
Polyclonal
Conjugate This IL2RG antibody is un-conjugated
(12), (9), (9), (5), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(59), (45), (36), (10), (10), (4), (4), (2), (2), (1), (1), (1), (1)
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Product Details anti-IL2RG Antibody

Target Details IL2RG Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human IL-2R gamma
Isotype IgG

Target Details IL2RG

Product Details anti-IL2RG Antibody Application Details Handling Images back to top
Antigen
Alternative Name Il-2r gamma (IL2RG Antibody Abstract)
Background

Interleukin 2 (IL2) receptor gamma chain (IL5212R gamma) is a cell surface glycoprotein expressed by a variety of leukocytes including T cells, B cells, NK cells, monocytes, macrophages, and neutrophils. IL2R gamma is also known as CD132, common cytokine receptor gamma chain, and gamma c. IL2R gamma forms complexes with other cell surface proteins including CD25 (IL2R alpha), CD122 (IL2R beta), CD124 (IL4R alpha), CD127 (IL7R), and others. IL2R gamma complexed with other cell surface proteins forms receptors for the cytokines IL2, IL4, IL7, IL9, and IL15. Acting through the IL2R gamma containing complexes, these cytokines regulate lymphocyte development and activation. Chemical cross linking experiments reveal that IL2R gamma is able to bind cytokines only when complexed with these other cell surface proteins. In addition to interacting with other cell surface glycoproteins, IL2R gamma associates with several cytoplasmic tyrosine kinases including JAK3 (Janus Kinase 3), JAK1, Syc, and Lyc. Cytokine binding to the IL2R gamma containing receptor complexes activates these tyrosine kinases. Once activated, these tyrosine kinases phosphorylate their associated receptors, creating docking sites for signaling molecules such as PI 3 kinase. The activated tyrosine kinases also phosphorylate downstream regulators including STAT3 (Signal Transducer and Activator of Transcription 3), STAT5, and STAT6. The various cytokines that bind to IL2R gamma containing receptor complexes exert their effects through unique repertoires of cytoplasmic signaling molecules. IL2, IL7, and IL9 exert their effects through cascades, which activate STAT3 and STAT5, while IL4 activates STAT6. IL2 and IL15 exert their effects through cascades, which activate the MAP kinase cascade. IL7 exerts its effects through a cascade that results in VDJ immunoglobulin gene rearrangement.

Subcellular location: Extracellular


Synonyms: P64, CIDX, IMD4, CD132, SCIDX, IL-2RG, SCIDX1, Cytokine receptor common subunit gamma, Interleukin-2 receptor subunit gamma, IL-2 receptor subunit gamma, IL-2R subunit gamma, gammaC, IL2RG
Gene ID 3561
UniProt P31785
Pathways JAK-STAT Signaling

Application Details

Product Details anti-IL2RG Antibody Target Details IL2RG Handling Images back to top
Application Notes WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Restrictions For Research Use only

Handling

Product Details anti-IL2RG Antibody Target Details IL2RG Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-IL2RG Antibody Target Details IL2RG Application Details Handling back to top
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-IL2RG antibody (Interleukin 2 Receptor, gamma) (AA 135-185) (ABIN2176981) Formalin-fixed and paraffin embedded human lung tissue labeled with Rabbit Anti-IL-2R...
Immunofluorescence (IF) image for anti-IL2RG antibody (Interleukin 2 Receptor, gamma) (AA 135-185) (ABIN2176981) Formalin-fixed and paraffin-embedded human lung labeled with Anti-IL-2R gamma Polyclo...
Western Blotting (WB) image for anti-IL2RG antibody (Interleukin 2 Receptor, gamma) (AA 135-185) (ABIN2176981) L1 rat spleen lysates L2 mouse heart lysates probed with Anti IL-2R gamma/CD132 Polyc...