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|Application / Reactivity||Human|
|Cellular Assay (CA)||1 Antibodies|
|Chromatin Immunoprecipitation (ChIP)||1 Antibodies|
|Dot Blot (DB)||3 Antibodies|
|Enzyme Immunoassay (EIA)||3 Antibodies|
|Flow Cytometry (FACS)||16 Antibodies|
|Immunoassay (IA)||1 Antibodies|
|Immunocytochemistry (ICC)||2 Antibodies|
|Immunofluorescence (IF)||9 Antibodies|
|Immunofluorescence (fixed cells) (IF/ICC)||1 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||27 Antibodies|
|Immunohistochemistry (IHC)||86 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||37 Antibodies|
|Immunoprecipitation (IP)||23 Antibodies|
|Immunostaining (ISt)||1 Antibodies|
|Simple Western (SimWes)||3 Antibodies|
|Antigen||Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) Antibodies|
|Conjugate||This STAT2 antibody is un-conjugated Alternatives|
Western Blotting (WB)
|2 references available|
|Supplier||Log in to see|
Product Details anti-STAT2 AntibodyTarget Details STAT2 Application Details Handling References for anti-STAT2 Antibody (ABIN967579) Images
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
|Purification||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|Immunogen||Phosphorylated Human Stat2 Peptide|
Target Details STAT2Product Details anti-STAT2 Antibody Application Details Handling References for anti-STAT2 Antibody (ABIN967579) Images back to top
|Alternative Name||Stat2 (STAT2 Antibody Abstract)|
Stat (Signal transducer and activators of transcription) proteins are critical mediators of the biologic activity of cytokines, including interleukins, interferons, erythropoietin, and growth factors. Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment/activation of Stat proteins by tyrosine phosphorylation. Active Stat proteins then move to the nucleus to promote transcription of cytokine-inducible genes. Seven Stat proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner. Stat1 and Stat2 are components of the ISGF3 (Interferon-Stimulated Gene Factor 3) complex, which is the primary transcription activator induced by the binding of the interferon to a specific cell-surface receptor. Stat2 is a 113-kDa protein having approximately 40% homology with Stat1a. Stat2 interacts with Stat1 for the efficient activation of Stat1 in response to IFN-a, which is essential for normal transcriptional activity of the ISGF3 complex. Stat2 phosphorylation at the tyrosine 690 residue (Y690) after IFN-a activation can occur independently of Stat1, but the localization and nuclear stability of phosphorylated Stat2 is dependent on Stat1.
The 7a/Stat2 monoclonal antibody recognizes the phosphorylated Y690 of human Stat2.
|Molecular Weight||113 kDa|
|Research Area||Signaling, Receptors, Inflammation|
|Pathways||JAK-STAT Signaling, Hepatitis C, CXCR4-mediated Signaling Events|
Application DetailsProduct Details anti-STAT2 Antibody Target Details STAT2 Handling References for anti-STAT2 Antibody (ABIN967579) Images back to top
Related Products: ABIN967389
|Restrictions||For Research Use only|
HandlingProduct Details anti-STAT2 Antibody Target Details STAT2 Application Details References for anti-STAT2 Antibody (ABIN967579) Images back to top
|Buffer||Aqueous buffered solution containing ≤0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store undiluted at 4°C.|
References for anti-STAT2 Antibody (ABIN967579)Product Details anti-STAT2 Antibody Target Details STAT2 Application Details Handling Images back to top
|Product cited in:||
Bromberg, Darnell: "The role of STATs in transcriptional control and their impact on cellular function." in: Oncogene, Vol. 19, Issue 21, pp. 2468-73, 2000
Heim: "The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus." in: European journal of clinical investigation, Vol. 26, Issue 1, pp. 1-12, 1996
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