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|Application / Reactivity||Human||Mouse (Murine)||Rat (Rattus)|
|Simple Western (SimWes)||3 Antibodies|
|Western Blotting (WB)||179 Antibodies||61 Antibodies||41 Antibodies|
|Immunostaining (ISt)||1 Antibodies|
|Immunoprecipitation (IP)||20 Antibodies||2 Antibodies||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||31 Antibodies||11 Antibodies||7 Antibodies|
|Immunohistochemistry (IHC)||92 Antibodies||27 Antibodies||19 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies||1 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||23 Antibodies||12 Antibodies||12 Antibodies|
|Antigen||Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This STAT2 antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-STAT2 AntibodyTarget Details STAT2 Application Details Handling Images
|Specificity||This antibody detects endogenous levels of STAT2 protein. (region surrounding Leu684)|
Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
|Purification||The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen|
|Purity||> 95 % pure by SDS-PAGE|
Target Details STAT2Product Details anti-STAT2 Antibody Application Details Handling Images back to top
|Alternative Name||STAT2 (STAT2 Antibody Abstract)|
|Background||Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expresion of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by Prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.Synonyms: Signal transducer and activator of transcription 2, p113|
|Molecular Weight||approx. 113 kDa|
|Research Area||Chromatin and Nuclear Signaling, Transcription Factors, Signaling, Receptors, Inflammation|
Application DetailsProduct Details anti-STAT2 Antibody Target Details STAT2 Handling Images back to top
ELISA: 1: 5000approx. 1: 10000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-STAT2 Antibody Target Details STAT2 Application Details Images back to top
|Buffer||Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||DO NOT FREEZE!|
|Storage Comment||Store the antibody undiluted at 2-8 °C.|
ImagesProduct Details anti-STAT2 Antibody Target Details STAT2 Application Details Handling back to top