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anti-Mouse (Murine) TYK2 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended TYK2 Antibody (supplied by: Log in to see )

Antigen
Tyrosine Kinase 2 (TYK2) Antibodies
  • JTK1
Reactivity
Human, Mouse (Murine)
170
62
49
1
Host
Rabbit
137
33
Clonality
Polyclonal
Conjugate
This TYK2 antibody is un-conjugated
7
7
7
5
5
5
2
2
2
2
2
2
2
2
2
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
99
67
61
24
23
22
11
8
1
1
1
Supplier
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Catalog No. ABIN498981
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008982679 ABIN302946 IHC (p) Rabbit IgG Log in to see Polyclonal
0.0008982679 ABIN1740492 IHC (p) Rabbit IgG Tyr1054 Log in to see Polyclonal
0.0008982679 ABIN746320 IHC (p) WB Biotin Rabbit IgG pTyr1054, pTyr1055 Log in to see Polyclonal
0.0008982679 ABIN746327 IHC (p) WB HRP Rabbit IgG pTyr1054, pTyr1055 Log in to see Polyclonal
0.0008982679 ABIN719593 IHC (p) WB Biotin Rabbit IgG Log in to see Polyclonal
0.0008982679 ABIN719600 IHC (p) WB HRP Rabbit IgG Log in to see Polyclonal
0.0008982679 ABIN746318 IF (p) IHC (p) WB Rabbit IgG pTyr1054, pTyr1055 Log in to see Polyclonal
0.0008982679 ABIN719591 IF (p) IHC (p) WB Rabbit IgG Log in to see Polyclonal
0.0008982679 ABIN2964549 IHC (p) ELISA WB Rabbit IgG N-Term Log in to see Polyclonal
0.0008982679 ABIN701290 IF (p) IHC (p) WB Rabbit IgG Log in to see Polyclonal
0.0008982679 ABIN4363627 IHC IHC (p) Rabbit Tyr1054 Log in to see Polyclonal
0.0008982679 ABIN2964548 IF IHC (p) WB Rabbit Val1048 Log in to see Polyclonal

Similar anti-TYK2 Antibodies

Application / Reactivity Mouse (Murine) Human
ELISA 6 Antibodies 67 Antibodies
Immunofluorescence (IF) 5 Antibodies 23 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 23 Antibodies 23 Antibodies
Immunohistochemistry (IHC) 18 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 13 Antibodies
Western Blotting (WB) 31 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies
Immunocytochemistry (ICC) 11 Antibodies
Immunofluorescence (Cultured Cells) (IF (cc)) 1 Antibodies

General

Antigen Tyrosine Kinase 2 (TYK2) Antibodies
Reactivity Human, Mouse (Murine)
(170), (62), (49), (1)
Host Rabbit
(137), (33)
Clonality
Polyclonal
Conjugate This TYK2 antibody is un-conjugated
(7), (7), (7), (5), (5), (5), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(99), (67), (61), (24), (23), (22), (11), (8), (1), (1), (1)
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Product Details anti-TYK2 Antibody

Target Details TYK2 Application Details Handling Images
Specificity This antibody detects endogenous levels of Tyk 2 protein. (region surrounding Val1048)
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse.
Purification Affinity chromatography
Purity > 95 % by SDS-PAGE

Target Details TYK2

Product Details anti-TYK2 Antibody Application Details Handling Images back to top
Antigen
Alternative Name TYK2 (TYK2 Antibody Abstract)
Background Tyk 2 belongs to the family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions occurring downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, recruit STAT transcription factors to the cytokine receptor where Tyk 2 is associated. Tyk 2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus, and bind to cis elements upstream of target gene promoters to regulating transcription. The canonical JAK-STAT pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Cytokine induced pro-inflammatory responses are attractive targets for anti-inflammatory therapies, specifically at the level of Jak-STAT signaling.Synonyms: JTK1, Non-receptor tyrosine-protein kinase TYK2
Molecular Weight approx. 134 kDa
Gene ID 7297
NCBI Accession NP_003322
UniProt P29597
Research Area Signaling, Tyrosine Kinases
Pathways JAK-STAT Signaling

Application Details

Product Details anti-TYK2 Antibody Target Details TYK2 Handling Images back to top
Application Notes Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-TYK2 Antibody Target Details TYK2 Application Details Images back to top
Concentration 1,0 mg/mL
Buffer Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Images

Product Details anti-TYK2 Antibody Target Details TYK2 Application Details Handling back to top
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-TYK2 antibody (Tyrosine Kinase 2) (ABIN498981) Immunohistochemistry (IHC) analyzes of Tyk 2 antibody in paraffin-embedded hum...
Western Blotting (WB) image for anti-TYK2 antibody (Tyrosine Kinase 2) (ABIN498981) Western blot (WB) analysis of Tyk 2 antibody in extracts from 293cells.