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Results show that ATF2 is highly expressed in renal cell carcinoma (RCC (show XRCC1 ELISA Kits)) tissues and promotes RCC (show XRCC1 ELISA Kits) cell proliferation, migration and invasion. The study suggests that ATF2 exerts an oncogenic role in RCC (show XRCC1 ELISA Kits).
These findings point to an oncogenic function for ATF2 in melanoma development that appears to be independent of its transcriptional activity.
this study demonstrates that CPEB2 (show CPEB2 ELISA Kits) alternative splicing is a major regulator of key cellular pathways linked to anoikis resistance and metastasis.
Noxin (show C11orf82 ELISA Kits) facilitated the expression of Cyclin D1 (show CCND1 ELISA Kits) and Cyclin E1 (show CCNE1 ELISA Kits) through activating P38 (show CRK ELISA Kits)-activating transcription factor 2 signaling pathway, thus enhanced cell growth of breast cancer
these observations suggest that CD99 (show CD99 ELISA Kits) is involved in the regulation of CD1a (show CD1A ELISA Kits) transcription and expression by increasing ATF-2.
This review provides an overview of the currently known upstream regulators and downstream targets of ATF2. [review]
TNF (show TNF ELISA Kits) induces the binding of ATF2 to the TNF (show TNF ELISA Kits)-responsive element.
miR (show MLXIP ELISA Kits)-204 may act as a tumor suppressor by directly targeting ATF2 in non-small cell lung cancer
the variant alleles of TSG101 (show TSG101 ELISA Kits) rs2292179 and ATF2 rs3845744 were associated with a reduced risk of breast cancer, particularly for subjects with BMI <24 (kg/m(2)) and postmenopausal women, respectively
Results reveal that mitochondrial ATF2 is associated with the induction of apoptosis and BRAF (show BRAF ELISA Kits) inhibitor resistance through Bim (show BCL2L11 ELISA Kits) activation.
This study reveals that Drosophila ATF-2 (dATF-2) is required for heterochromatin assembly, whereas the stress-induced phosphorylation of dATF-2, via Mekk1 (show MAP3K1 ELISA Kits)-p38 (show MAPK14 ELISA Kits), disrupts heterochromatin.
ATF-2 is critical for regulation of fat metabolism.
dATF-2 is activated by the locomotor while it increases sleep, suggesting a role for dATF-2 as a regulator to connect sleep with locomotion.
The current data shows a timely GFP translation in bovine embryos depending on sequences in the 3'UTR (show UTS2R ELISA Kits) of ATF1 (show AFT1 ELISA Kits)/2, and indicates a difference between short and long isoforms.
Ang II (show AGT ELISA Kits) increases endothelial arginase activity/expression through a p38 MAPK (show MAPK14 ELISA Kits)/ATF-2 pathway leading to reduced endothelial NO production
Data indicate that Ser738/742-to-glutamate (show GRIN2A ELISA Kits) protein kinase D (show PRKD1 ELISA Kits) mutant increased AngII-induced CREB (show CREB1 ELISA Kits) protein and activating transcription factor 2 phosphorylation, and phospho-CREB (show CREB1 ELISA Kits) binding to the steroidogenic acute regulatory protein (show STAR ELISA Kits) promoter.
adiponectin inhibited endoplasmic reticulum stress and apoptosis of adipocyte in vivo and in vitro by activating the AMPK (show PRKAA1 ELISA Kits)/PPARalpha (show PPARA ELISA Kits)/ATF2 pathway.
Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting were used to detect the mRNA and protein expressions of p-p38MAPK (show MAPK14 ELISA Kits), AAT, signal transducer and activator of transcription 1 (STAT1 (show STAT1 ELISA Kits)) and activating transcription factor2 (ATF2)
increased expression of the gene encoding PKCepsilon (show PRKCE ELISA Kits) and abundance of phosphorylated, transcriptionally active ATF2 were observed in advanced-stage melanomas and correlated with decreased FUK (show FUK ELISA Kits) expression
These data identified a role for ATF2 in regulating melanocyte responses.
suppression of tumorigenesis by JNK (show MAPK8 ELISA Kits) requires ATF2.
Taken together, our observations indicated that SOCS2 (show SOCS2 ELISA Kits) could suppress myotube formation, act as an anti-regulator of mitochondria biogenesis via inhibiting p38 MAPK (show MAPK14 ELISA Kits) signal pathway.
ATF2 is an important transcriptional factor relating to inflammation through the suppression of ATF3 (show ATF3 ELISA Kits) in M1 macrophages of White adipose tissue.
ATF-2 plays critical roles for proper expression of tyrosine hydroxylase (show TH ELISA Kits) gene and for neurite extension of catecholaminergic neurons, possibly through repressor-like action.
these studies show that the IL-1beta (show IL1B ELISA Kits)-induced increase in intestinal tight junction permeability was regulated by p38 (show CRK ELISA Kits) kinase activation of ATF-2 and by ATF-2 regulation of MLCK (show MYLK ELISA Kits) gene activity
ATF2-based luciferase reporter to monitor non-canonical Wnt (show WNT2 ELISA Kits) signaling in Xenopus embryos.
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro\; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Several alternatively spliced transcript variants have been found for this gene.
, activating transcription factor 2 splice variant ATF2-var2
, cAMP response element-binding protein CRE-BP1
, cAMP responsive element binding protein 2, formerly
, cAMP-dependent transcription factor ATF-2
, cAMP-responsive element-binding protein 2
, cyclic AMP-dependent transcription factor ATF-2
, cyclic AMP-responsive element-binding protein 2
, activating transcription factor-2, isoform A
, activating transcription factor-2, isoform C
, activating transcription factor-2, isoform B
, cyclic AMP response element binding protein 2
, chimerin (chimaerin) 1