We are preparing the requested document. Please wait, this may take a while...!
|Application / Reactivity||Human|
|Enzyme Immunoassay (EIA)||3 Antibodies|
|Flow Cytometry (FACS)||7 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||8 Antibodies|
|Immunofluorescence (IF)||41 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||24 Antibodies|
|Immunohistochemistry (IHC)||70 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||23 Antibodies|
|Immunoprecipitation (IP)||14 Antibodies|
|Proximity Ligation Assay (PLA)||2 Antibodies|
|Western Blotting (WB)||128 Antibodies|
|Antigen||Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) Antibodies|
|Epitope||AA 231-335 Alternatives|
|Conjugate||This MAP2K6 antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-MAP2K6 AntibodyTarget Details MAP2K6 Application Details Handling References for anti-MAP2K6 Antibody (ABIN393607) Images
|Specificity||MAP2K6 (AAH12009, 231 a.a. ~ 335 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Purification||This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Immunogen||MAP2K6 (AAH12009, 231 a.a. ~ 335 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
Target Details MAP2K6Product Details anti-MAP2K6 Antibody Application Details Handling References for anti-MAP2K6 Antibody (ABIN393607) Images back to top
|Alternative Name||MAP2K6 (MAP2K6 Antibody Abstract)|
|Background||Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1|
|Molecular Weight||37492 DA|
|Research Area||Phospho-specific antibodies, Cell Signaling, Protein Modifications, Transcription Factors, Cell Structure|
|Pathways||MAPK Signaling, TLR Signaling|
Application DetailsProduct Details anti-MAP2K6 Antibody Target Details MAP2K6 Handling References for anti-MAP2K6 Antibody (ABIN393607) Images back to top
|Application Notes||Western blot = 1:500-1000|
Background: This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
|Restrictions||For Research Use only|
HandlingProduct Details anti-MAP2K6 Antibody Target Details MAP2K6 Application Details References for anti-MAP2K6 Antibody (ABIN393607) Images back to top
|Buffer||PBS with 0.09% (w/v) sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
|Storage Comment||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles|
|Expiry Date||6 months|
References for anti-MAP2K6 Antibody (ABIN393607)Product Details anti-MAP2K6 Antibody Target Details MAP2K6 Application Details Handling Images back to top
Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).
Sturchler, Feurstein, McDonald et al.: "Mechanism of oxidative stress-induced ASK1-catalyzed MKK6 phosphorylation." in: Biochemistry, Vol. 49, Issue 19, pp. 4094-102, 2010 (PubMed).
Huang, Li, Chung: "Activin A induction of erythroid differentiation through MKK6-p38alpha/p38beta pathway is inhibited by follistatin." in: Journal of cellular physiology, Vol. 223, Issue 3, pp. 687-94, 2010 (PubMed).
Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).
Dumka, Puri, Carayol et al.: "Activation of the p38 Map kinase pathway is essential for the antileukemic effects of dasatinib." in: Leukemia & lymphoma, Vol. 50, Issue 12, pp. 2017-29, 2009 (PubMed).
ImagesProduct Details anti-MAP2K6 Antibody Target Details MAP2K6 Application Details Handling References for anti-MAP2K6 Antibody (ABIN393607) back to top