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anti-Human PAK1 Antibodies:
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Human PAK1 Primary Antibody for IHC - ABIN966796
Alexander, Yang, Hinds: Cellular senescence requires CDK5 repression of Rac1 activity. in Molecular and cellular biology 2004
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Human Polyclonal PAK1 Primary Antibody for WB - ABIN1944750
Brown, Stowers, Baer, Trejo, Coughlin, Chant: Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. in Current biology : CB 1997
Show all 3 Pubmed References
Human Polyclonal PAK1 Primary Antibody for IHC - ABIN966797
Thiel, Reeder, Pfaff, Coleman, Sells, Chernoff: Cell cycle-regulated phosphorylation of p21-activated kinase 1. in Current biology : CB 2002
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Human Polyclonal PAK1 Primary Antibody for DB, IF - ABIN389799
El-Baba, Mahadevan, Fahlbusch, S, Rau, Gali-Muhtasib, Schneider-Stock: Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer. in Molecular cancer 2014
Human Polyclonal PAK1 Primary Antibody for IF, IHC - ABIN362773
Rashid, Banerjee, Nikolic: Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology. in The Journal of biological chemistry 2001
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Human Polyclonal PAK1 Primary Antibody for ELISA, WB - ABIN188561
Zhao, Ma, Calon, Harris-White, Yang, Lim, Morihara, Ubeda, Ambegaokar, Hansen, Weisbart, Teter, Frautschy, Cole: Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease. in Nature neuroscience 2006
Human Monoclonal PAK1 Primary Antibody for IF, IHC (p) - ABIN562102
Cook, Sanchez-Carbente, Lachance, Radzioch, Tremblay, Khandjian, DesGroseillers, Murai: Fragile X related protein 1 clusters with ribosomes and messenger RNAs at a subset of dendritic spines in the mouse hippocampus. in PLoS ONE 2011
Human Polyclonal PAK1 Primary Antibody for ICC, IF - ABIN4343458
Geiger, Velic, Macek, Lundberg, Kampf, Nagaraj, Uhlen, Cox, Mann: Initial quantitative proteomic map of 28 mouse tissues using the SILAC mouse. in Molecular & cellular proteomics : MCP 2013
results represent the first evidence that Pak1 links extracellular signals to the genetic cascade of transcription factors necessary for cranial neural crest specification
These findings expand the role of phosphoinositides in kinase signaling and suggest how altered phosphoinositide metabolism may upregulate Pak1 activity in cancer cells.
The data suggest that EphA4 activation sequesters active Cdc42 (show CDC42 Antibodies) and in this way down-regulates cell-cell adhesion.
Pak1 inhibition interferes with the guidance of mesendoderm migration by directional cues residing in the extracellular matrix of the blastocoel roof, and with mesendoderm translocation in the embryo.
the oxidative stress-induced (show SQSTM1 Antibodies) down-regulation of PAK1 activity could be involved in the loss of mesencephalic dopaminergic neurons.
the expression of PAK1 is inversely correlated with the level of miR (show MLXIP Antibodies)-494 in human breast cancer samples. Furthermore, re-expression of PAK1 partially reverses miR (show MLXIP Antibodies)-494-mediated proliferative and clonogenic inhibition as well as migration and invasion suppression in breast cancer cells
Our study revealed that PAK1 may play a crucial role in the progression of OSCC. Studying the role of PAK1 and its substrates is likely to enhance our understanding of oral carcinogenesis and potential therapeutic value of PAKs in oral cancer.
The effect of PAK1 modulation on tumorigenesis, and on resistance to treatment with 5-fluorouracil (5-FU), was measured by sphere formation in vitro and by growth of xenografted tumors in vivo. The results show that PAK1 activity correlated with the expression of CSC markers and the CD44 (show CD44 Antibodies) isoform profile, and with tumor growth both in vitro and in vivo.
this study shows that PAK1 may be a potential tumor marker and therapeutic target of prostate cancer
Our results from clinical samples also suggest that Threonine 209 phosphorylation by Pak1 could be a potential therapeutic target and of great clinical relevance with implications for Runx3 (show RUNX3 Antibodies) inactivation in cancer cells where Runx3 (show RUNX3 Antibodies) is known to be oncogenic. The findings presented in this study provide evidence of Runx3 (show RUNX3 Antibodies)-Threonine 209 phosphorylation as a molecular switch in dictating the tissue-specific dualistic functions
Abnormalities in the PAK1 and PAK3 mRNA levels as well as their altered coexpression patterns were observed in the postmortem brain of subjects with depression. Dysregulated PAK1/PAK3 dependent signaling may be a key factor responsible for volumetric abnormalities observed in the hippocampus and in the prefrontal cortex in depression resulting in altered connectivity of these regions.
Short-term treatment of nascent melanoma tumors with PAK inhibitors that block RhoJ (show RHOJ Antibodies) signaling halts the growth of BRAF (show BRAF Antibodies) mutant melanoma tumors in vivo and induces apoptosis in melanoma cells in vitro via a BAD-dependent mechanism
these data strongly support a critical interplay between prolactin (show PRL Antibodies) and estrogen via PAK1 and suggest that ligand-independent activation of ERalpha (show ESR1 Antibodies) through prolactin (show PRL Antibodies)/PAK1 may impart resistance to anti-estrogen therapies.
Given the central role of p21-Activated kinase 1 (PAK1) in vital signaling pathways, studies suggest that clinical development of PAK1 inhibitors will require careful investigation of their safety and efficacy.
These results establish a novel signaling process whereby PAK1 upregulates COX-2 (show COX2 Antibodies), reduces anandamide levels and restricts tonic endocannabinoids-mediated processes.
The findings suggest that PAK1 deficiency may underlie an increased diabetic susceptibility. Discovery of ways to remediate glycaemic dysregulation via altering PAK1 or its downstream effectors offers promising opportunities for disease intervention.
present work presents the correlation between DSCAM gene overexpression and a dysregulation of the PAK pathway, resulting in altered morphological parameters of neuronal plasticity in the trisomic cell line, namely decreased number and length of processes
These results identify Pak1 and Pak2 (show PAK2 Antibodies) as redundant regulators of myoblast differentiation in vitro and in vivo and as components of the promyogenic Ncad (show CDH2 Antibodies)/Cdo (show CDO1 Antibodies)/Cdc42 (show CDC42 Antibodies) signaling pathway.
PAK-mediated phosphorylation of PKD1 at Ser203 triggers its membrane dissociation and subsequent entry into the nucleus, thereby regulating the phosphorylation of PKD1 nuclear targets, including class IIa histone deacetylases.
These results implicate PAK1 as a regulator of Pancreatic stellate cells activation, proliferation and apoptosis. Targeting stromal PAK1 could increase therapeutic response and survival of patients with pancreatic cancer.
The authors conclude that PAK1, besides its role in virus entry, also plays a relevant role in vaccinia virus dissemination.
PAK1 contributes to initiation of intestinal carcinogenesis
Pak1 is essential for adaptive physiological exercise-induced cardiac remodelling and support previous evidence that demonstrates Pak1 signalling is important for cardiac growth and survival.
Further investigations identified Pak1-ERM (show ETV5 Antibodies) as a downstream signaling cascade upon Rac1 activation in the luminal epithelium necessary for uterine receptivity...Rac1 via P38 MAPK (show MAPK14 Antibodies) signaling ensures timely epithelial apoptotic death at postimplantation.
FOXO-Pak1 pathway was recently shown to regulate mammalian neuronal polarity, our findings indicate that the roles of FOXO and Pak1 in neuronal migration are most likely conserved from C. elegans to higher organisms.
PAK1 promotes reproduction, whereas it inactivates HSP16.2 gene and shortens lifespan.
Pak-1 interacts with Wnt (show WNT2 Antibodies) signaling to regulate tissue polarity and gene expression.
only PAK-1 functions in the GIT/PIX (show ARHGEF7 Antibodies)/PAK pathway independently of RAC (show AKT1 Antibodies)/CDC42 (show CDC42 Antibodies) GTPases.
Data show that combined loss of ROCK and PAK, or ROCK and MRCK (show CDC42BPA Antibodies), completely prevented embryonic elongation, but a constitutively active form of MLC-4 could only rescue a lack of MRCK (show CDC42BPA Antibodies).
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
p21 GTPase-associated kinase 1
, p21-activated kinase 1
, p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)
, putative CDKN1A-activated kinase 1
, STE20 homolog, yeast
, p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)
, serine/threonine-protein kinase PAK 1
, CDC42/RAC effector kinase PAK-A
, activated protein kinase alpha
, p21 (CDKN1A)-activated kinase 1
, protein kinase MUK2