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Browse our anti-PAK1 (PAK1) Antibodies

Full name:
anti-P21-Activated Kinase 1 Antibodies (PAK1)
On www.antibodies-online.com are 319 P21-Activated Kinase 1 (PAK1) Antibodies from 28 different suppliers available. Additionally we are shipping PAK1 Kits (12) and PAK1 Proteins (12) and many more products for this protein. A total of 358 PAK1 products are currently listed.
Synonyms:
AW045634, pak, PAK-1, Paka, PAKalpha, X-PAK1, XPak1
list all antibodies Gene Name GeneID UniProt
PAK1 5058 Q13153
PAK1 18479  
PAK1 29431 P35465

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Top referenced anti-PAK1 Antibodies

  1. Cow (Bovine) Polyclonal PAK1 Primary Antibody for WB - ABIN372696 : Boda, Alberi, Nikonenko, Node-Langlois, Jourdain, Moosmayer, Parisi-Jourdain, Muller: The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 (PubMed)
    Show all 5 references for ABIN372696

  2. Human Polyclonal PAK1 Primary Antibody for EIA - ABIN358296 : Li, Guan: The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak. in The Journal of biological chemistry 2004 (PubMed)
    Show all 5 references for ABIN358296

  3. Human Polyclonal PAK1 Primary Antibody for EIA - ABIN358352 : DerMardirossian, Schnelzer, Bokoch: Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase. in Molecular cell 2004 (PubMed)
    Show all 5 references for ABIN358352

  4. Human Polyclonal PAK1 Primary Antibody for IF, IHC (p) - ABIN197378 : Parsons, Monypenny, Ameer-Beg, Millard, Machesky, Peter, Keppler, Schiavo, Watson, Chernoff, Zicha, Vojnovic, Ng: Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells. in Molecular and cellular biology 2005 (PubMed)
    Show all 4 references for ABIN197378

  5. Human Polyclonal PAK1 Primary Antibody for WB - ABIN1944750 : Brown, Stowers, Baer, Trejo, Coughlin, Chant: Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. in Current biology : CB 1997 (PubMed)
    Show all 3 references for ABIN1944750

  6. Human Polyclonal PAK1 Primary Antibody for EIA, IHC (p) - ABIN360317 : Chen, Yin, Zhu, Yan, Ji, Chen, Cai, Zhang, Zong, Hu, Yuan, Shen, Gu: The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis. in The Journal of biological chemistry 2003 (PubMed)
    Show all 3 references for ABIN360317

  7. Human Polyclonal PAK1 Primary Antibody for ELISA, WB - ABIN185685 : Zhao, Ma, Calon, Harris-White, Yang, Lim, Morihara, Ubeda, Ambegaokar, Hansen, Weisbart, Teter, Frautschy, Cole: Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease. in Nature neuroscience 2006 (PubMed)

  8. Human Polyclonal PAK1 Primary Antibody for DB, IF - ABIN389799 : El-Baba, Mahadevan, Fahlbusch, S, Rau, Gali-Muhtasib, Schneider-Stock: Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer. in Molecular cancer 2014 (PubMed)

More Antibodies against PAK1 Interaction Partners

Xenopus laevis P21-Activated Kinase 1 (PAK1) interaction partners

  1. results represent the first evidence that Pak1 links extracellular signals to the genetic cascade of transcription factors necessary for cranial neural crest specification

  2. These findings expand the role of phosphoinositides in kinase signaling and suggest how altered phosphoinositide metabolism may upregulate Pak1 activity in cancer cells.

  3. The data suggest that EphA4 activation sequesters active Cdc42 (show CDC42 Antibodies) and in this way down-regulates cell-cell adhesion.

  4. Pak1 inhibition interferes with the guidance of mesendoderm migration by directional cues residing in the extracellular matrix of the blastocoel roof, and with mesendoderm translocation in the embryo.

Human P21-Activated Kinase 1 (PAK1) interaction partners

  1. Formation of filopodia by membrane glycoprotein (show CD86 Antibodies) M6a (Gpm6a (show GPM6A Antibodies)) requires actin regulator coronin-1a (Coro1a (show CORO1A Antibodies)), known to regulate plasma membrane localization and activation of Rac1 and its downstream effector Pak1.

  2. This study showed that PAK1 messenger RNA levels were significantly downregulated specifically in deep layer 3 pyramidal cells in patient with schizophrenia.

  3. Data show association of G protein-coupled receptor (show ADRA1A Antibodies) kinase-interacting protein (show CIB1 Antibodies) 1 (GIT1), p21 (show CDKN1A Antibodies)-activated kinase interacting exchange factor (betaPIX (show ARHGEF7 Antibodies)), and p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1) with centrosomes.

  4. PAK1 is associated with the aggressive tumor behavior and poor prognosis of head and neck cancer.

  5. Data indicate that NOTCH1 (show NOTCH1 Antibodies) receptor intracellular domain (NOTCH1 (show NOTCH1 Antibodies)-IC) physically interacts with serine-threonine-protein kinase PAK 1 (PAK1) in intact cells.

  6. Pak1 promote endometrial cancer cell proliferation.

  7. PAK1-mediated MORC2 (show MORC2 Antibodies) phosphorylation promotes gastric tumorigenesis

  8. Studied the role of PAK1/Crk axis in transduction of the oncogenic KRAS signal in non-small cell lung cancer (NSCLC).

  9. Pak1 and Pak2 (show PAK2 Antibodies) counteract centrosome separation in a kinase-dependent manner.

  10. Pak1 is an important factor in the initiation and progression of atherogenesis.

Mouse (Murine) P21-Activated Kinase 1 (PAK1) interaction partners

  1. Nischarin (show NISCH Antibodies) inhibits neurite outgrowth by blocking PAK1 activation in neurons.

  2. results indicate that NCAM (show NCAM1 Antibodies) is delivered to the cell surface through a kinesin-1-mediated transport mechanism in a PAK1-dependent manner.

  3. propose that by repressing Pak1 expression, Rb prevents Rac1 hyperactivity usually associated with cancer and related to cytoskeletal derangements that disrupt cell adhesion, consequently enhancing cancer cell migratory capacity

  4. Pak1 is an important factor in the initiation and progression of atherogenesis.

  5. miR (show MLXIP Antibodies)-155 regulates the delicate balance between PAK1-mediated proliferation and apoptosis in T cells impacting lymphoid organ size and function.

  6. These results suggest that PAK1 regulates cortical development by promoting the proliferation of neural progenitor cells.

  7. These data indicate that while PAK1 has the potential to contribute to neovascularization and wound healing, PAK2 (show PAK2 Antibodies) may functionally compensate when PAK1 is deficient.

  8. PAK1 overexpression and activation in inflammation and colitis-associated cancer promote NF-kappaB (show NFKB1 Antibodies) activity via suppression of PPARgamma (show PPARG Antibodies) in intestinal epithelial cells.

  9. PAK1 is involved in the ability of cells to sense the orientation of stiffness in collagen substrates and generate contractile forces that affect cell extension formation.

  10. PAK1 is an essential controller of inflammatory macrophage polarization, regulating immune responses against pathogenic stimuli.

Caenorhabditis elegans (C. elegans) P21-Activated Kinase 1 (PAK1) interaction partners

  1. FOXO-Pak1 pathway was recently shown to regulate mammalian neuronal polarity, our findings indicate that the roles of FOXO and Pak1 in neuronal migration are most likely conserved from C. elegans to higher organisms.

  2. PAK1 promotes reproduction, whereas it inactivates HSP16.2 gene and shortens lifespan.

  3. Pak-1 interacts with Wnt (show WNT2 Antibodies) signaling to regulate tissue polarity and gene expression.

  4. only PAK-1 functions in the GIT/PIX (show ARHGEF7 Antibodies)/PAK pathway independently of RAC (show AKT1 Antibodies)/CDC42 (show CDC42 Antibodies) GTPases.

  5. Data show that combined loss of ROCK and PAK, or ROCK and MRCK (show CDC42BPA Antibodies), completely prevented embryonic elongation, but a constitutively active form of MLC-4 could only rescue a lack of MRCK (show CDC42BPA Antibodies).

PAK1 Antigen Profile

Antigen Summary

This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PAK1

  • p21 protein (Cdc42/Rac)-activated kinase 1 (pak1) antibody
  • p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1) antibody
  • p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1) antibody
  • Protein PAK-1 (pak-1) antibody
  • AW045634 antibody
  • pak antibody
  • PAK-1 antibody
  • Paka antibody
  • PAKalpha antibody
  • X-PAK1 antibody
  • XPak1 antibody

Protein level used designations for PAK1

p21 GTPase-associated kinase 1 , p21-activated kinase 1 , p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) , putative CDKN1A-activated kinase 1 , STE20 homolog, yeast , alpha-PAK , p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related) , p65-PAK , serine/threonine-protein kinase PAK 1 , CDC42/RAC effector kinase PAK-A , activated protein kinase alpha , PAK-1 , p21 (CDKN1A)-activated kinase 1 , p68-PAK , protein kinase MUK2

GENE ID SPECIES
398126 Xenopus laevis
451439 Pan troglodytes
100190755 Taeniopygia guttata
5058 Homo sapiens
18479 Mus musculus
29431 Rattus norvegicus
607885 Canis lupus familiaris
533729 Bos taurus
180873 Caenorhabditis elegans
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