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CRH/UCN-R activation promotes luteal development and/or structure-function in monkeys during the menstrual cycle.
Ventral tegmental area CRH-BP is involved in the initial stages of escalated ethanol drinking.
These studies demonstrate a role for the pituitary CRH-BP in attenuating the HPA (show HPSE Proteins) response to stress in female mice.
estrogen-regulated expression of corticotropin-releasing hormone-binding protein in lactotropes in female mice suggests that the pituitary is an important site for interactions between the hypothalamic-pituitary-adrenal axis and other endocrine systems
Evidence is presented suggesting that the CRH-BP may be required for corticotropin-releasing factor (show CRH Proteins)-induced potentiation of NMDA receptors in dopaminergic neurons of the ventral tegmental area.
GnRH induces a 3.7-fold increase in CRH-BP mRNA levels via multiple intracellular signaling pathways and a multipartite GnRH response element.
analysis of regulation and function of CRH-BP [review]
Deletion of corticotropin-releasing factor binding protein selectively impairs maternal, but not intermale aggression.
Genetic polymorphism rs7718461 in the CRHBP gene showed significant association with overall pain severity during the year after motor vehicle collision.
These results suggest that the CRH (show CRH Proteins) and CRH-BP genes have no direct effect on Irritable bowel syndrome status.
Homozygosity for the CRHBP rs10055255 T allele was associated with significantly fewer post-ICU PTSD and depressive symptoms
Significant main effects on children's cortisol reactivity were found for loci on CRHR1 (show CRHR1 Proteins) and CRHBP.
A significant association was observed in Blacks, Hispanics and Whites between birth weight and maternal CRH-BP single nucleotide polymorphism genotypes.
There was a significant association between the s/s homozygous genotype for the 5-HTTLPR (show SLC6A4 Proteins) polymorphism of SLC6A4 (show SLC6A4 Proteins) gene and restrained eating condition (p = 0.033
CRHBP variation may predispose, independently and additively, to suicidal behavior in individuals who have experienced childhood trauma.
interaction of CRHR1 (show CRHR1 Proteins) SNP rs110402 and SNP rs3811939 predicts high risk of comorbid alcoholism in schizophrenic patients
results extend recent preclinical and clinical findings implicating the CRH-BP in stress-related alcoholism and confirm the role of the Asp40 allele of the OPRM1 (show OPRM1 Proteins) gene in reward-driven alcohol phenotypes
genotype analyses yielded significant association between CRHBP and suicide attempt (P = 0.035); interaction analysis showed significant interaction between CRH (show CRH Proteins) receptor type 1 and CRHBP in influencing suicide attempt and severity of suicidal behaviour
Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy.
corticotropin-releasing factor-binding protein
, Corticotropin-releasing factor-binding protein
, corticotropin releasing hormone binding protein
, corticotropin-releasing factor-binding protein-like
, CRF-binding protein
, corticotropin-releasing hormone-binding protein
, corticotropin releasing hormone-binding protein
, corticotropin releasing factor binding protein
, neuropeptide binding protein