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The data demonstrate that vanin-1/pantetheinase controls fibrosis, vasculopathy, autoimmunity, and oxidative stress in Systemic sclerosis (SSc (show CYP11A1 Antibodies)).
oxidized LDL (Ox-LDL) can significantly induce VNN1 expression through an ERK1/2 (show MAPK1/3 Antibodies)/cyclooxygenase-2 (COX-2 (show PTGS2 Antibodies))/PPARalpha (show PPARA Antibodies) signaling pathway.
absence of vanin-1 activity improves insulin (show INS Antibodies) sensitivity.
serum pantetheinas, encoded by the VNN1 gene, level regulates erythrocyte life span and modulates the risk of developing complicated malaria.
Results suggest an important role for VNN1 in regulating hepatic gluconeogenesis.
Data indicate that genetic ablation of the Vanin-1 (Vnn1) gene in SF-1 (NR5A1 (show NR5A1 Antibodies)) transgenic mice significantly reduced the severity of neoplastic lesions in the adrenal cortex.
Microparticle internalization required the interaction of the ectoenzyme Vanin-1 (VNN1), an abundant surface protein on the microparticles, with lipid raft domains of endothelial cells.
Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model.
Data show that Vanin-1(-/-) mice better controlled inflammatory reaction and intestinal injury in either acute (NSAID administration) or chronic (Schistosoma infection) inflammation.
Data show that Vanin-1(-/-) mice, which lack cysteamine in tissues, exhibit resistance to oxidative injury induced by whole-body gamma-irradiation or paraquat.
findings suggest that the metabolic pathway catalyzed by VNN1 pantetheinase plays a suppressive role in IAV infection in the respiratory tract, especially in severe conditions under hypercytokinemia
Data show that G protein-coupled receptor (show ADRA1A Antibodies), family C, group 5, member A (show CXCL14 Antibodies) protein (GPRC5A (show GPRC5A Antibodies)) regulates oxidative stress through vanin 1 protein (VNN1).
These data suggest that urinary vanin-1 is an early predictive biomarker for decline in eGFR (show EGFR Antibodies) in patients with urothelial carcinoma after dosing of cisplatin
VNN1 contributes to corticosteroid responsiveness, and changes in VNN1 nasal epithelial mRNA expression and VNN1 promoter methylation might be clinically useful biomarkers of treatment response in asthmatic children.
Our study provides strong biological evidence for the association of the identified SNP with BP and suggests that vanin-1 misfolding and degradation are the underlying molecular mechanism.
show that hepatic vanin-1 is under extremely sensitive regulation by PPARalpha (show PPARA Antibodies) and that plasma vanin activity could serve as a readout of changes in PPARalpha (show PPARA Antibodies) activity in human subjects
The X-ray crystal structure of human vanin 1 at 2.25 A resolution is presented, which is the first reported structure from the vanin family, as well as a crystal structure of vanin 1 bound to a specific inhibitor.
Serum vanin-1 levels may be low in the end-stage renal failure and transiently increase after transplant owing to transient renal function deterioration, which does not lead to elevation of serum creatinine levels in renal transplant patients.
Our results suggest that vanin-1 can distinguish between chronic responders and non-responders ITP (show ITPA Antibodies) patients as well as between newly diagnosed ITP (show ITPA Antibodies) patients and healthy controls.
This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24.
, vanin 1, gene 1
, pantetheine hydrolase
, vascular non-inflammatory molecule 1
, vannin 1