Browse our anti-CASQ2 (CASQ2) Antibodies

Full name:
anti-Calsequestrin 2 (Cardiac Muscle) Antibodies (CASQ2)
On www.antibodies-online.com are 76 Calsequestrin 2 (Cardiac Muscle) (CASQ2) Antibodies from 14 different suppliers available. Additionally we are shipping CASQ2 Proteins (15) and many more products for this protein. A total of 95 CASQ2 products are currently listed.
Synonyms:
AA033488, AW146219, CAL, cardCSQ, CASQ1, CASQ2, cCSQ, DKFZp468D075, ESTM52, PDIB2
list all antibodies Gene Name GeneID UniProt
CASQ2 12373 O09161
CASQ2 845 O14958
CASQ2 29209 P51868

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anti-Mouse (Murine) CASQ2 Antibodies:

anti-Human CASQ2 Antibodies:

anti-Rat (Rattus) CASQ2 Antibodies:

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Top referenced anti-CASQ2 Antibodies

  1. Human Polyclonal CASQ2 Primary Antibody for WB - ABIN1881138 : Kirchhefer, Wehrmeister, Postma, Pohlentz, Mormann, Kucerova, Müller, Schmitz, Schulze-Bahr, Wilde, Neumann: The human CASQ2 mutation K206N is associated with hyperglycosylation and altered cellular calcium handling. in Journal of molecular and cellular cardiology 2010 (PubMed)
    Show all 2 references for 1881138

  2. Human Monoclonal CASQ2 Primary Antibody for ELISA, WB - ABIN560181 : Leatherbury, Yu, Chatterjee, Walker, Yu, Tian, Lo: A novel mouse model of X-linked cardiac hypertrophy. in American journal of physiology. Heart and circulatory physiology 2008 (PubMed)

  3. Human Monoclonal CASQ2 Primary Antibody for EIA, WB - ABIN614312 : Eckstein, Plicht, Lax, Neuhäuser, Mann, Lederbogen, Heckmann, Esser, Morgenthaler: Thyrotropin receptor autoantibodies are independent risk factors for Graves' ophthalmopathy and help to predict severity and outcome of the disease. in The Journal of clinical endocrinology and metabolism 2006 (PubMed)

More Antibodies against CASQ2 Interaction Partners

Mouse (Murine) Calsequestrin 2 (Cardiac Muscle) (CASQ2) interaction partners

  1. Calcium entry activated by ablation of both JP45 (show JSRP1 Antibodies)-CASQ1 (show CASQ1 Antibodies) and JP45 (show JSRP1 Antibodies)-CASQ2 complexes supports tetanic force development in slow twitch soleus muscles.

  2. The minimal KEKE motif of TRN (show TNPO1 Antibodies) involved in the interactions with CSQ2, HRC (show HRC Antibodies) and RyR2 (show RYR2 Antibodies) within the Ca2 (show CA2 Antibodies)+ release units of cardiac sarcoplasmic reticulum has been defined.

  3. While CASQ2 stabilizes RyR2 (show RYR2 Antibodies) rendering it refractory in the diastolic phase, HRC (show HRC Antibodies) enhances RyR2 (show RYR2 Antibodies) activity facilitating RyR2 (show RYR2 Antibodies) recovery from refractoriness.

  4. Results show that CASQ2 deletion causes abnormal sarcoplasmic reticulum Ca(2 (show CA2 Antibodies)+) release and selective interstitial fibrosis in the atrial pacemaker complex, which disrupt SAN pacemaking and increase susceptibility to atrial fibrillation

  5. Viral gene transfer of wild-type CASQ2 into the heart of R33Q mice prevents and reverts severe manifestations of catecholaminergic polymorphic ventricular tachycardia.

  6. Cardiac hypertrophy and calcium waves in CASQ2-null cardiac muscle are governed by the ryanodine receptor (Ryr)2 Ca2+ sensor.

  7. Expression of CASQ2-R33Q influences molecular and ultra-structural heart development; post-natal, adaptive changes appear capable of ensuring until adulthood a new pathophysiological equilibrium.

  8. Mutant CASQ2(D307H) protein retains some of its physiological function. Its expression decreases with age and is inversely related to arrhythmia severity.

  9. Qualitatively similar results were obtained in a hybrid strain created by crossing CASQ2 knockout mice with mice deficient in phospholamban (show PLN Antibodies).

  10. The triadin (show TRDN Antibodies)-to-calsequestrin ratio is a critical modulator of the sarcoplasmic reticulum Ca(2 (show CA2 Antibodies)+) signaling in ventricular myocytes.

Human Calsequestrin 2 (Cardiac Muscle) (CASQ2) interaction partners

  1. a direct interaction exists between RyR2 (show RYR2 Antibodies) and CSQ2, is reported.

  2. induced Pluripotent Stem Cell-derived cardiomyocytes are useful for investigating the similarities/differences in the pathophysiological consequences of RyR2 (show RYR2 Antibodies) versus CASQ2 mutations underlying Catecholaminergic polymorphic ventricular tachycardia.

  3. Mutations in the MYBPC3 (show MYBPC3 Antibodies) and CASQ2 genes and six combinations between loci in the MYBPC3 (show MYBPC3 Antibodies), MYH7 (show MYH7 Antibodies) and CASQ2 genes were responsible for cardiomyopathy risk in a studied cohort.

  4. We observed association between a CASQ2 polymorphism and SCA due to VA in patients with CAD (show CAD Antibodies) adjusting for CHF and independent associations between CASQ2 SNPs and CHF adjusting for SCA.

  5. The sarcoplasmic reticulum calcium content in human type II fibres is primarily determined by the CSQ1 (show CASQ1 Antibodies) abundance, and in type I fibres, by the combined amounts of both CSQ1 (show CASQ1 Antibodies) and CSQ2.

  6. Molecular analysis of the CASQ2 gene in 43 probands with Catecholaminergic polymorphic ventricular tachycardia were performed and eight mutations in five patients, were identified.

  7. In a consanguineous family, a novel homozygous CASQ2 mutation (p.L77P) was identified in a child with CPVT who required implantation of a cardioverter defibrillator due to episodes of syncope while on medical therapy

  8. A review of the physiology of Casq2 in cardiac Ca2 (show CA2 Antibodies)+ handling and discuss pathophysiological mechanisms that lead to catecholaminergic polymorphic ventricular tachycardia caused by CASQ2 mutations.

  9. patients with CASQ2-associated CPVT should be recommended to receive ICDs to prevent sudden death when medical therapy is not effective.

  10. Aspartate to histidine casq2 mutation causes arrhythmia in cardiomyocytes generated from catecholaminergic polymorphic ventricular tachycardia patients.

Pig (Porcine) Calsequestrin 2 (Cardiac Muscle) (CASQ2) interaction partners

  1. endogenous ankyrin repeat domain 1 protein and CASQ2 are co-enriched in piglet cardiac Purkinje cells

Rabbit Calsequestrin 2 (Cardiac Muscle) (CASQ2) interaction partners

  1. data shows that phosphorylated calsequestrin is required for high capacity calcium buffering and suggest that ryanodine receptor (show RYR3 Antibodies) inhibition by calsequestrin is mediated by junctin (show ASPH Antibodies)

CASQ2 Antigen Profile

Antigen Summary

The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest.

Alternative names and synonyms associated with CASQ2

  • calsequestrin 2 (cardiac muscle) (CASQ2) antibody
  • calsequestrin 2 (Casq2) antibody
  • calsequestrin 2 (cardiac muscle) (Casq2) antibody
  • AA033488 antibody
  • AW146219 antibody
  • CAL antibody
  • cardCSQ antibody
  • CASQ1 antibody
  • CASQ2 antibody
  • cCSQ antibody
  • DKFZp468D075 antibody
  • ESTM52 antibody
  • PDIB2 antibody

Protein level used designations for CASQ2

calsequestrin 2 (cardiac muscle) , Calsequestrin-2 , calsequestrin, cardiac muscle isoform , calsequestrin-2 , cardiac calsequestrin , calsequestrin 2, fast-twitch, cardiac muscle , SR calcium binding protein , aspartactin , calsequestrin homologue , calsequestrin, skeletal muscle isoform , calsequestrin-1 , laminin-binding protein

GENE ID SPECIES
100172607 Pongo abelii
12373 Mus musculus
845 Homo sapiens
29209 Rattus norvegicus
395198 Gallus gallus
483134 Canis lupus familiaris
397436 Sus scrofa
100009261 Oryctolagus cuniculus
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