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anti-Human Insulin Receptor antibody for Functional Studies

Recommended Insulin Receptor Antibody (supplied by: Log in to see )

Antigen
Insulin Receptor (INSR) Antibodies
  • 18402
  • 4932439J01Rik
  • CD220
  • cd220
  • CG18402
  • CTK-1
  • D630014A15Rik
  • DIHR
  • DILR
  • dInR
  • dINR
  • dinr
  • dInr
  • DInR
  • DInr
  • dInsR
  • dir
  • DIR
  • dIR
  • Dir-a
  • Dir-b
  • DIRbeta
  • dIRH
  • DIRH
  • Dmel\\CG18402
  • er10
  • HHF5
  • hhf5
  • Inr
  • INR
  • inr
  • Inr-alpha
  • Inr-beta
  • INS
  • INSR
  • InsR
  • insulin/insulin-like growth factor receptor
  • ir
  • IR
  • IR-A
  • ir-A
  • IR-B
  • l(3)05545
  • l(3)93Dj
  • l(3)er10
  • lnR
  • NV14476
Epitope
Chain beta
32
29
21
20
15
10
9
7
6
6
6
6
5
5
5
5
4
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
265
81
57
11
8
5
4
2
1
1
1
1
1
1
1
Host
Mouse
219
75
3
Clonality
Monoclonal
Conjugate
This Insulin Receptor antibody is un-conjugated
21
16
9
9
7
7
1
1
1
1
1
1
1
1
1
1
1
1
Application
Functional Studies (Func), Immunoprecipitation (IP), Western Blotting (WB)
167
122
49
43
35
18
18
12
11
10
10
8
7
7
2
2
2
1
Supplier
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Catalog No. ABIN1106089
$ 522.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.00087760796 ABIN1106087 Func Mouse IgG1 Chain alpha Log in to see 47-9 6
0.00087760796 ABIN1106086 Func IP Mouse IgG2a Chain alpha Log in to see 83-14 6
0.00087760796 ABIN201104 Func ELISA WB Mouse IgG1 C-Term Log in to see CT-3
0.00087760796 ABIN228602 Func Mouse IgG1 Log in to see 47-9
0.00087760796 ABIN228606 Func IHC (p) ELISA WB Mouse IgG1 C-Term Log in to see
0.00087760796 ABIN224667 Func IP ELISA Mouse IgG1, kappa C-Term Log in to see
0.00087760796 ABIN228598 Func ELISA Mouse IgG2a Log in to see 83-14
0.00087760796 ABIN228599 Func IP ELISA Mouse IgG2a, kappa AA 469-592 Log in to see 83-14
0.00087760796 ABIN228607 Func IHC (p) ELISA WB Mouse IgG1 C-Term Log in to see
0.00087760796 ABIN190249 Func IP Mouse IgG2a Chain alpha Log in to see
0.00087760796 ABIN190251 Func Mouse IgG1 Chain alpha Log in to see
0.00087760796 ABIN190252 Func IP WB Mouse IgG2b Chain beta Log in to see
0.00087760796 ABIN228601 Func FACS IHC (p) ELISA Mouse IgG1, kappa Log in to see
0.00087760796 ABIN201093 Func IP WB Mouse IgG1 Log in to see
0.00087760796 ABIN2963158 Func IP Mouse Subunit alpha Log in to see 83-14
0.00087760796 ABIN2963157 Func Mouse Subunit alpha Log in to see 47-9
0.00087760796 ABIN2963159 Func IP WB Mouse Subunit beta Log in to see 18-44
0.00087760796 ABIN2963156 Func IP Mouse Log in to see 83-7

Top referenced anti-Insulin Receptor antibody for Functional Studies

Similar anti-Insulin Receptor Antibodies

Application / Reactivity Human
Blocking Reagent (BR) 4 Antibodies
Dot Blot (DB) 18 Antibodies
ELISA 106 Antibodies
Enzyme Immunoassay (EIA) 7 Antibodies
Flow Cytometry (FACS) 10 Antibodies
Functional Studies (Func) 19 Antibodies
Immunochromatography (IC) 2 Antibodies
Immunocytochemistry (ICC) 8 Antibodies
Immunofluorescence (IF) 9 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 36 Antibodies
Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)) 1 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 6 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 42 Antibodies
Immunoprecipitation (IP) 52 Antibodies
Intracellular Flow Cytometry (ICFC) 2 Antibodies
Mass Cytometry (CyTOF) 2 Antibodies

General

Antigen Insulin Receptor (INSR) Antibodies
Epitope Chain beta
(32), (29), (21), (20), (15), (10), (9), (7), (6), (6), (6), (6), (5), (5), (5), (5), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(265), (81), (57), (11), (8), (5), (4), (2), (1), (1), (1), (1), (1), (1), (1)
Host Mouse
(219), (75), (3)
Clonality (Clone)
Monoclonal   ( )
Conjugate This Insulin Receptor antibody is un-conjugated
(21), (16), (9), (9), (7), (7), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Functional Studies (Func), Immunoprecipitation (IP), Western Blotting (WB)
(167), (122), (49), (43), (35), (18), (18), (12), (11), (10), (10), (8), (7), (7), (2), (2), (2), (1)
Pubmed 6 references available
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Product Details anti-Insulin Receptor Antibody

Target Details Insulin Receptor Application Details Handling References for anti-Insulin Receptor Antibody (ABIN1106089) Images
Specificity Recognizes the Human Insulin Receptor beta. Low-level of cross reactivity with Bovine and Rabbit.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Protein G Chromatography.
Immunogen Human Placental Insulin Receptor.
Clone 18-44
Isotype IgG2b

Target Details Insulin Receptor

Product Details anti-Insulin Receptor Antibody Application Details Handling References for anti-Insulin Receptor Antibody (ABIN1106089) Images back to top
Antigen
Alternative Name CD220 / INSR (INSR Antibody Abstract)
Background The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide linked subunits in a beta-alpha-alpha-beta configuration. The beta subunit (95 kDa) possesses a single transmembrane domain, whereas the alpha subunit (135 kDa) is completely extracellular. The insulin receptor exhibits receptor tyrosine kinase (RTK) activity. RTKs are single pass transmembrane receptors that possess intrinsic cytoplasmic enzymatic activity, catalyzing the transfer of the gamma phosphate of ATP to tyrosine residues in protein substrates. RTKs are essential components of signal transduction pathways that affect cell proliferation, differentiation, migration and metabolism. Included in this large protein family are the insulin receptor and the receptors for growth factors such as epidermal growth factor, fibroblast growth factor and vascular endothelial growth factor. Receptor activation occurs through ligand binding, which facilitates receptor dimerization and autophosphorylation of specific tyrosine residues in the cytoplasmic portion. The interaction of insulin with the alpha subunit of the insulin receptor activates the protein tyrosine kinase of the beta subunit, which then undergoes an autophosphorylation that increases its tyrosine kinase activity. Three adapter proteins, IRS1, IRS2 and Shc, become phosphorylated on tyrosine residues following insulin receptor activation. These three phosphorylated proteins then interact with SH2 domain containing signaling proteins.Synonyms: Insulin Receptor
Gene ID 3643
NCBI Accession NP_000199
UniProt P06213
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways NF-kappaB Signaling, RTK Signaling, AMPK Signaling

Application Details

Product Details anti-Insulin Receptor Antibody Target Details Insulin Receptor Handling References for anti-Insulin Receptor Antibody (ABIN1106089) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-Insulin Receptor Antibody Target Details Insulin Receptor Application Details References for anti-Insulin Receptor Antibody (ABIN1106089) Images back to top
Buffer PBS or Medium which is identical to that used in the assay system. Contains no preservatives.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C to -70 °C.

References for anti-Insulin Receptor Antibody (ABIN1106089)

Product Details anti-Insulin Receptor Antibody Target Details Insulin Receptor Application Details Handling Images back to top
Background publications

Zhang, Roth: "A region of the insulin receptor important for ligand binding (residues 450-601) is recognized by patients' autoimmune antibodies and inhibitory monoclonal antibodies." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 21, pp. 9858-62, 1991

Soos, Siddle: "Immunological relationships between receptors for insulin and insulin-like growth factor I. Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptors." in: The Biochemical journal, Vol. 263, Issue 2, pp. 553-63, 1990

Prigent, Stanley, Siddle: "Identification of epitopes on the human insulin receptor reacting with rabbit polyclonal antisera and mouse monoclonal antibodies." in: The Journal of biological chemistry, Vol. 265, Issue 17, pp. 9970-7, 1990

Soos, OBrien, Brindle, Stigter, Okamoto, Whittaker, Siddle: "Monoclonal antibodies to the insulin receptor mimic metabolic effects of insulin but do not stimulate receptor autophosphorylation in transfected NIH 3T3 fibroblasts." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 14, pp. 5217-21, 1989

Taylor, Soos, Wells, Argyraki, Siddle: "Insulin-like and insulin-inhibitory effects of monoclonal antibodies for different epitopes on the human insulin receptor." in: The Biochemical journal, Vol. 242, Issue 1, pp. 123-9, 1987

Soos, Siddle, Baron, Heward, Luzio, Bellatin, Lennox: "Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor." in: The Biochemical journal, Vol. 235, Issue 1, pp. 199-208, 1986