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anti-Dog (Canine) NFKBIB antibody for Immunohistochemistry

Recommended NFKBIB Antibody (supplied by: Log in to see )

Antigen
Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, beta (NFKBIB) Antibodies
  • NFKBIB
  • IKB-beta
  • IKappaBbeta
  • IkB
  • IkBb
  • IKBB
  • TRIP9
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
  • nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta
  • NFKBIB
  • LOC100359283
  • Nfkbib
Epitope
C-Term
44
19
18
14
12
8
7
4
4
4
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rabbit, Rat (Rattus)
185
95
79
9
7
7
6
4
4
1
1
1
Host
Rabbit
154
35
Clonality
Polyclonal
Conjugate
This NFKBIB antibody is un-conjugated
6
6
5
3
3
3
2
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
130
73
73
34
28
23
14
7
4
3
1
1
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Catalog No. ABIN2775837
$ 229.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN601596 IHC Rabbit IgG pSer23 Log in to see Polyclonal
1 ABIN601595 IHC WB Rabbit IgG Log in to see Polyclonal

Top referenced anti-NFKBIB antibody for Immunohistochemistry

Similar anti-NFKBIB Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Rattus) Cow (Bovine) Dog (Canine) Horse (Equine) Guinea Pig Rabbit
Immunofluorescence (fixed cells) (IF/ICC) 4 Antibodies 3 Antibodies 2 Antibodies
Western Blotting (WB) 127 Antibodies 59 Antibodies 44 Antibodies 9 Antibodies 7 Antibodies 7 Antibodies 5 Antibodies 6 Antibodies
Proximity Ligation Assay (PLA) 1 Antibodies
Immunoprecipitation (IP) 13 Antibodies 6 Antibodies 5 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 34 Antibodies 19 Antibodies 19 Antibodies 1 Antibodies

General

Antigen Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, beta (NFKBIB) Antibodies
Epitope C-Term
(44), (19), (18), (14), (12), (8), (7), (4), (4), (4), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rabbit, Rat (Rattus)
(185), (95), (79), (9), (7), (7), (6), (4), (4), (1), (1), (1)
Host Rabbit
(154), (35)
Clonality
Polyclonal
Conjugate This NFKBIB antibody is un-conjugated
(6), (6), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Immunohistochemistry (IHC), Western Blotting (WB)
(130), (73), (73), (34), (28), (23), (14), (7), (4), (3), (1), (1)
Pubmed 1 reference available
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Product Details anti-NFKBIB Antibody

Target Details NFKBIB Application Details Handling References for anti-NFKBIB Antibody (ABIN2775837) Images
Sequence MLRPNPILAR LLRAHGAPEP EGEDEKSGPC SSSSDSDSGD EGDEYDDIVV
Predicted Reactivity Cow: 91%, Dog: 83%, Guinea Pig: 92%, Horse: 92%, Human: 100%, Mouse: 85%, Rabbit: 77%, Rat: 92%
Characteristics This is a rabbit polyclonal antibody against NFKBIB. It was validated on Western Blot and immunohistochemistry.
Purification Protein A purified
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human NFKBIB

Target Details NFKBIB

Product Details anti-NFKBIB Antibody Application Details Handling References for anti-NFKBIB Antibody (ABIN2775837) Images back to top
Antigen
Alternative Name NFKBIB (NFKBIB Antibody Abstract)
Background NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).[supplied by OMIM].NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).[supplied by OMIM].
Alias Symbols: IKBB, TRIP9
Protein Interaction Partner: VPS52, UBC, BAG3, TSPAN1, GIT2, RELA, REL, CSNK2A1, CDC25A, BAK1, APP, ZBTB7A, DNAJA3, IKBKB, CHUK, BRAP, IKBKG, TRE17, NFKBIA, NCOR2, PPARG, ESR2, POLR1D, POLR1E, POLR1A, POLR1C, POLR2H, NKIRAS2, POLR1B, NKIRAS1, LRPPRC, RASAL2, MTIF2, BTRC, CUL1, SKP1,
Protein Size: 356
Molecular Weight 38 kDa
Gene ID 4793
NCBI Accession NM_002503, NP_002494
UniProt Q15653
Pathways NF-kappaB Signaling, Activation of Innate immune Response, Maintenance of Protein Location, Toll-Like Receptors Cascades

Application Details

Product Details anti-NFKBIB Antibody Target Details NFKBIB Handling References for anti-NFKBIB Antibody (ABIN2775837) Images back to top
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 356 AA

Restrictions For Research Use only

Handling

Product Details anti-NFKBIB Antibody Target Details NFKBIB Application Details References for anti-NFKBIB Antibody (ABIN2775837) Images back to top
Format Liquid
Concentration 1 mg/mL
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-NFKBIB Antibody (ABIN2775837)

Product Details anti-NFKBIB Antibody Target Details NFKBIB Application Details Handling Images back to top
Background publications

Joo, Hahn, Kwon, Sadikot, Blackwell, Christman: "Hepatitis C virus core protein suppresses NF-kappaB activation and cyclooxygenase-2 expression by direct interaction with IkappaB kinase beta." in: Journal of virology, Vol. 79, Issue 12, pp. 7648-57, 2005

Images

Product Details anti-NFKBIB Antibody Target Details NFKBIB Application Details Handling References for anti-NFKBIB Antibody (ABIN2775837) back to top
Supplier Images
Western Blotting (WB) image for anti-NFKBIB antibody (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, beta) (C-Term) (ABIN2775837) WB Suggested Anti-NFKBIB Antibody Titration: 5.0ug/ml
ELISA Titer: 1...
Immunohistochemistry (IHC) image for anti-NFKBIB antibody (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, beta) (C-Term) (ABIN2775837) anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, beta (NFKBIB) (C-Term) antibody (Image 2)
Western Blotting (WB) image for anti-NFKBIB antibody (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, beta) (C-Term) (ABIN2775837) WB Suggested Anti-NFKBIB
Antibody Titration: 5.0 µg/mL ELISA Titer: 1:.12500 <...
Immunohistochemistry (IHC) image for anti-NFKBIB antibody (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, beta) (C-Term) (ABIN2775837) Human Intestine