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|Antigen||Nerve Growth Factor Receptor (NGFR) Antibodies|
|Reactivity||Primate, Dog (Canine), Raccoon (Procyon lotor), Cat (Feline), Pig (Porcine), Rabbit Alternatives|
|Conjugate||This NGFR antibody is un-conjugated Alternatives|
Immunocytochemistry (ICC), Immunohistochemistry (IHC)
|3 references available|
|Supplier||Log in to see|
Product Details anti-NGFR AntibodyTarget Details NGFR Application Details Handling References for anti-NGFR antibody (ABIN350715) Images
|Specificity||Specific for p75NTR.|
|Immunogen||Human melanoma cell lines|
Target Details NGFRProduct Details anti-NGFR Antibody Application Details Handling References for anti-NGFR antibody (ABIN350715) Images back to top
|Alternative Name||p75NTR (NGFR Antibody Abstract)|
Function: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
Subunit: Homodimer, disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3.
Subcellular location: Membrane, Single-pass type I membrane protein. Also known as: Tumor necrosis factor receptor superfamily member 16, P08138, low-affinity nerve growth factor receptor, NGF receptor, Gp80-LNGFR, p75 ICD, low affinity neurotrophin receptor p75NTR, CD271 antigen, NGFR, TNFRSF16.
|Pathways||NF-kappaB Signaling, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding|
Application DetailsProduct Details anti-NGFR Antibody Target Details NGFR Handling References for anti-NGFR antibody (ABIN350715) Images back to top
A concentration of 2-10 µg/ml is recommended.
The optimal working concentration should be determined by the end user. This antibody may also be used for immunoabsorptive purification of NGF-receptors. See also the eLab Book at the end of this page.
|Restrictions||For Research Use only|
HandlingProduct Details anti-NGFR Antibody Target Details NGFR Application Details References for anti-NGFR antibody (ABIN350715) Images back to top
|Reconstitution||Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.|
|Handling Advice||Avoid freeze and thaw cycles.|
|Storage||4 °C/-20 °C|
|Storage Comment||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Expiry Date||12 months|
References for anti-NGFR antibody (ABIN350715)Product Details anti-NGFR Antibody Target Details NGFR Application Details Handling Images back to top
Tremere, Pinaud, Grosche, Haertig, Rasmusson: "Antibody for human p75 LNTR identifies cholinergic basal forebrain of non-primate species." in: Neuroreport, Vol. 11, Issue 10, pp. 2177-83, 2000
Zupan, Osborne, Smith, Siegel, Leimgruber, Johnson: "Identification, purification, and characterization of truncated forms of the human nerve growth factor receptor." in: The Journal of biological chemistry, Vol. 264, Issue 20, pp. 11714-20, 1989
Ross, Grob, Bothwell, Elder, Ernst, Marano, Ghrist, Slemp, Herlyn, Atkinson: "Characterization of nerve growth factor receptor in neural crest tumors using monoclonal antibodies." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, Issue 21, pp. 6681-5, 1984