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|Antigen||Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) Antibodies|
|Epitope||AA 22-72 Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This TNFRSF1A antibody is un-conjugated Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|2 references available|
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Product Details anti-TNFRSF1A AntibodyTarget Details TNFRSF1A Application Details Handling References for anti-TNFRSF1A antibody (ABIN682018) Images
|Specificity||This antibody will recognize Isoform 1, 4 and 5, but not Isoform 2 or 3.|
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human TNF Receptor I|
Target Details TNFRSF1AProduct Details anti-TNFRSF1A Antibody Application Details Handling References for anti-TNFRSF1A antibody (ABIN682018) Images back to top
|Alternative Name||TNFR1 (TNFRSF1A Antibody Abstract)|
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Subcellular location: Extracellular, Cell membrane
Synonyms: Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor 1, TNF-R1, Tumor necrosis factor receptor type I, TNF-RI, TNFR-I, p55, p60, CD120a, TNFRSF1A, TNFAR, TNFR1
|Pathways||NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Hepatitis C|
Application DetailsProduct Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Handling References for anti-TNFRSF1A antibody (ABIN682018) Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Application Details References for anti-TNFRSF1A antibody (ABIN682018) Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
References for anti-TNFRSF1A antibody (ABIN682018)Product Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Application Details Handling Images back to top
|Product cited in:||
Abdel-Hamid, El-Azab, Moustafa: "Macrolide antibiotics differentially influence human HepG2 cytotoxicity and modulate intrinsic/extrinsic apoptotic pathways in rat hepatocellular carcinoma model." in: Naunyn-Schmiedeberg's archives of pharmacology, Vol. 390, Issue 4, pp. 379-395, 2017 Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Rat (Rattus)).
Fukui, Nakamura, Takahashi, Iwamoto, Hasegawa, Yanagihara, Nakamura, Okayama, Kawakami: "Tumor necrosis factor alpha inhibitors have no effect on a human T-lymphotropic virus type-I (HTLV-I)-infected cell line from patients with HTLV-I-associated myelopathy." in: BMC immunology, Vol. 18, Issue 1, pp. 7, 2017 Method employed by authors: Immunofluorescence (fixed cells) (IF/ICC) (Sample species: Human).
ImagesProduct Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Application Details Handling References for anti-TNFRSF1A antibody (ABIN682018) back to top