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|Application / Reactivity||Human|
|Agonist (Agon)||1 Antibodies|
|Blocking Antibody (Inhibition)||2 Antibodies|
|Cell Culture (CC)||2 Antibodies|
|Enzyme Immunoassay (EIA)||13 Antibodies|
|Flow Cytometry (FACS)||39 Antibodies|
|Functional Studies (Func)||18 Antibodies|
|Immunoassay (IA)||5 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||7 Antibodies|
|Immunofluorescence (IF)||19 Antibodies|
|Immunohistochemistry (IHC)||25 Antibodies|
|Immunohistochemistry (Acetone-fixed) (IHC (af))||1 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||21 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||18 Antibodies|
|Immunoprecipitation (IP)||27 Antibodies|
|Neutralization (Neut)||2 Antibodies|
|Western Blotting (WB)||98 Antibodies|
|Antigen||Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) Antibodies|
|Conjugate||This TNFRSF1B antibody is conjugated to PE Alternatives|
Flow Cytometry (FACS)
|6 references available|
|Supplier||Log in to see|
Product Details anti-TNFRSF1B AntibodyTarget Details TNFRSF1B Application Details Handling References for anti-TNFRSF1B Antibody (ABIN2662426) Images
|Purification||The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.|
Target Details TNFRSF1BProduct Details anti-TNFRSF1B Antibody Application Details Handling References for anti-TNFRSF1B Antibody (ABIN2662426) Images back to top
|Alternative Name||CD120b (TNFRSF1B Antibody Abstract)|
|Background||CD120b, also known as TNFRII or TNFRSF1B, belongs to the TNF receptor superfamily and can interact with ligands TNF-α and TNF-β (also known as LT-α). It is a 75 kD type I transmembrane protein expressed on lymphocytes, monocytes, and granulocytes. When present in a heterocomplex with CD120a, it induces the recruitment of anti-apoptotic molecules, c-IAP1 and c-IAP2 that possess E3 ubiquitin ligase activity. Mutations in CD120b are associated with TNF-associated periodic syndrome (TRAPS) or periodic fever syndrome.|
|Pathways||NF-kappaB Signaling, Apoptosis|
Application DetailsProduct Details anti-TNFRSF1B Antibody Target Details TNFRSF1B Handling References for anti-TNFRSF1B Antibody (ABIN2662426) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFRSF1B Antibody Target Details TNFRSF1B Application Details References for anti-TNFRSF1B Antibody (ABIN2662426) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Protect from prolonged exposure to light. Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-TNFRSF1B Antibody (ABIN2662426)Product Details anti-TNFRSF1B Antibody Target Details TNFRSF1B Application Details Handling Images back to top
Chen, Wu, Zhou et al.: "TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 190, Issue 3, pp. 1076-84, 2013 (PubMed).
Hijdra, Vorselaars, Grutters et al.: "Differential expression of TNFR1 (CD120a) and TNFR2 (CD120b) on subpopulations of human monocytes." in: Journal of inflammation (London, England), Vol. 9, Issue 1, pp. 38, 2013 (PubMed).
Kohno, Brewer, Baker et al.: "A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 21, pp. 8331-5, 1990 (PubMed).
Andrews, Berger, Ware et al.: "Characterization of the receptor for tumor necrosis factor (TNF) and lymphotoxin (LT) on human T lymphocytes. TNF and LT differ in their receptor binding properties and the induction of MHC class I ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 144, Issue 7, pp. 2582-91, 1990 (PubMed).
Tartaglia, Weber, Figari et al.: "The two different receptors for tumor necrosis factor mediate distinct cellular responses." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 20, pp. 9292-6, 1991 (PubMed).
Nophar, Kemper, Brakebusch et al.: "Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form ..." in: The EMBO journal, Vol. 9, Issue 10, pp. 3269-78, 1990 (PubMed).
ImagesProduct Details anti-TNFRSF1B Antibody Target Details TNFRSF1B Application Details Handling References for anti-TNFRSF1B Antibody (ABIN2662426) back to top