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anti-Human POFUT1 Antibodies:
anti-Mouse (Murine) POFUT1 Antibodies:
anti-Rat (Rattus) POFUT1 Antibodies:
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Human Polyclonal POFUT1 Primary Antibody for EIA, IHC (p) - ABIN954232
Luo, Haltiwanger: O-fucosylation of notch occurs in the endoplasmic reticulum. in The Journal of biological chemistry 2005
Show all 3 references for ABIN954232
Human Polyclonal POFUT1 Primary Antibody for WB - ABIN525219
Annani-Akollor, Wang, Fan, Liu, Padhiar, Zhang: Downregulated protein O-fucosyl transferase 1 (Pofut1) expression exerts antiproliferative and antiadhesive effects on hepatocytes by inhibiting Notch signalling. in Biomedicine & pharmacotherapy 2014
POFUT1, POGLUT1 (show POGLUT1 Antibodies) and ADAM10 (show ADAM10 Antibodies) are processing enzymes that are involved in different steps of Notch (show NOTCH1 Antibodies) receptor activation in the epidermis; the roles of these unique enzymes in a single pathway may explain both the overlapping and distinct clinical features of DDD (show KRT5 Antibodies) and RAK (show FRK Antibodies) patients
High expression of POFUT1 correlates with aggressive clinicopathological characteristics and poor prognosis of hepatocellular carcinoma patients.
The upregulation of poFUT1 by LIF (show LIF Antibodies) facilitated trophoblast cell migration and invasion through activating the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling pathway.
Silencing of Pofut1 expression exerted antiproliferative and antiadhesive effects on hepatocytes.
Only a novel 1-bp deletion (c.246+5delG) in POFUT1 was found in a Chinese family with Dowling-Degos disease (DDD (show KRT5 Antibodies)). No other novel mutation or this deletion was detected in POFUT1 in a second DDD (show KRT5 Antibodies) family and a sporadic DDD (show KRT5 Antibodies) case by Sanger Sequencing.
Identification of six pathogenic POFUT1 mutations in Dowling-Degos disease patients of different ethnic origin.
POFUT1 expression can contribute to cancer progression and that POFUT1 may serve as a diagnostic marker and a therapeutic target for OSCCs.
The protein product of POFUT1 plays a significant and conserved role in melanin synthesis and transport.
fucosyltransferases, O-FucT-1 is a soluble protein that localizes to the endoplasmic reticulum and recognizes properly folded epidermal growth factor (show EGF Antibodies)-like repeats.
Pofut1 and O-fucose have roles in mammalian Notch (show NOTCH1 Antibodies) signaling
results establish the critical role of Pofut1 on Notch (show NOTCH1 Antibodies) pathway activation during myogenic differentiation
mDLL1 O-fucosylation by POFUT1 is dispensable for ligand function
Loss of Pofut1 is associated with myeloid hyperplasia and impaired lymphopoiesis.
Pofut1 is required for Notch (show NOTCH1 Antibodies) signaling upstream of NICD1.
These data are consistent with a role for Pofut1 in AChR aggregation during synaptogenesis via the regulation of the synaptogenic activity of muscle agrin (show AGRN Antibodies).
Reduced POFUT1 levels might affect Notch (show NOTCH1 Antibodies) trafficking or overall O-fucosylation.
This gene encodes a member of the glycosyltransferase O-Fuc family. This enzyme adds O-fucose through an O-glycosidic linkage to conserved serine or threonine residues in the epidermal growth factor-like repeats of a number of cell surface and secreted proteins. O-fucose glycans are involved in ligand-induced receptor signaling. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
GDP-fucose protein O-fucosyltransferase 1
, putative protein-O-fucosyltransferase
, peptide-O-fucosyltransferase 1
, protein-O-fucosyltransferase 1
, protein O-fucosyltransferase 1
, o-fucosyltransferase protein