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Browse our anti-Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) Antibodies

Full name:
anti-Nuclear Receptor Subfamily 1, Group H, Member 4 Antibodies (NR1H4)
On www.antibodies-online.com are 106 Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) Antibodies from 20 different suppliers available. Additionally we are shipping Nuclear Receptor Subfamily 1, Group H, Member 4 Kits (22) and Nuclear Receptor Subfamily 1, Group H, Member 4 Proteins (7) and many more products for this protein. A total of 141 Nuclear Receptor Subfamily 1, Group H, Member 4 products are currently listed.
Synonyms:
AI957360, BAR, Fxr, HRR-1, HRR1, NR1H4, RIP14, Rxrip14, zgc:92742, zgc:110190
list all antibodies Gene Name GeneID UniProt
NR1H4 9971 Q96RI1
NR1H4 20186 Q60641
NR1H4 60351 Q62735

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All available anti-Nuclear Receptor Subfamily 1, Group H, Member 4 Antibodies

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Top referenced anti-Nuclear Receptor Subfamily 1, Group H, Member 4 Antibodies

  1. Human Polyclonal NR1H4 Primary Antibody for WB - ABIN2773865 : Kaeding, Bouchaert, Bélanger, Caron, Chouinard, Verreault, Larouche, Pelletier, Staels, Bélanger, Barbier: Activators of the farnesoid X receptor negatively regulate androgen glucuronidation in human prostate cancer LNCAP cells. in The Biochemical journal 2008 (PubMed)
    Show all 2 references for ABIN2773865

  2. Human Monoclonal NR1H4 Primary Antibody for IF, ELISA - ABIN523347 : Chen, Song, Valanejad, Vasilenko, More, Qiu, Chen, Lai, Slitt, Stoner, Yan, Deng: Bile salt export pump is dysregulated with altered farnesoid X receptor isoform expression in patients with hepatocellular carcinoma. in Hepatology (Baltimore, Md.) 2013 (PubMed)
    Show all 2 references for ABIN523347

  3. Dog (Canine) Polyclonal NR1H4 Primary Antibody for EIA, WB - ABIN375197 : Huang, Ma, Zhang, Qatanani, Cuvillier, Liu, Dong, Huang, Moore: Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. in Science (New York, N.Y.) 2006 (PubMed)

  4. Chicken Polyclonal NR1H4 Primary Antibody for IHC, WB - ABIN2778066 : Pineda Torra, Freedman, Garabedian: Identification of DRIP205 as a coactivator for the Farnesoid X receptor. in The Journal of biological chemistry 2004 (PubMed)

More Antibodies against Nuclear Receptor Subfamily 1, Group H, Member 4 Interaction Partners

Human Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) interaction partners

  1. induction of SOCS3 (show SOCS3 Antibodies) may be a novel mechanism by which FXR exerts its anti-hepatocellular carcinoma effects

  2. Mutations in NR1H4 cause progressive familial intrahepatic cholestasis.

  3. we drew a conclusion that curcumin attenuated Alcoholic liver disease by modulating lipid deposition in hepatocytes via a Nrf2 (show GABPA Antibodies)/FXR activation-dependent mechanism

  4. miR (show MLXIP Antibodies)-122 is a novel target gene of FXR, and the upregulation of miR (show MLXIP Antibodies)-122 by FXR represses the growth of hepatocellular carcinoma cells, suggesting that FXR may serve as a key transcriptional regulator for manipulating miR (show MLXIP Antibodies)-122 expression

  5. IL-18 (show IL18 Antibodies) repressed FXR mRNA and protein levels in HepG2 cells.

  6. FXR signalling in ileum biopsies of humans positively correlates with body mass index.

  7. FXR activation in L cells decreases proglucagon (show GCG Antibodies) expression by interfering with the glucose-responsive factor Carbohydrate-Responsive Element Binding Protein (ChREBP (show MLXIPL Antibodies)) and GLP-1 (show GCG Antibodies) secretion by inhibiting glycolysis.

  8. FXR is decreased in obese animal models associated with INS (show INS Antibodies) resistance. Regulation of bile acids and FXR in the stage of obesity may prevent more metabolism disorders.

  9. These results provide important information to prioritize chemicals for further investigation, and suggest possible modes of action of compounds in FXR signaling.

  10. FXR may regulate SOD3 (show SOD3 Antibodies) expression to suppress reactive oxygen species production, resulting in decreasing JNK (show MAPK8 Antibodies) activity.

Rabbit Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) interaction partners

  1. FXR is expressed in the ovary, in all regions of the oviduct, and all portions of the vagina of rabbits.

Mouse (Murine) Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) interaction partners

  1. FXR can exert its hepatoprotective functions by controlling inflammation and mitochondrial functions, possibly involving an FXR-PPAR delta (show PPARD Antibodies) cross-talk

  2. Activated farnesoid X receptor (show xpr1 Antibodies) attenuates apoptosis and liver injury in autoimmune hepatitis.

  3. FXR activation maintains endogenous glutathione homeostasis and protects the kidney in uninephrectomized mice from obesity-induced injury

  4. FXR down regulates MCP-1 (show CPT1B Antibodies) expression in macrophages.

  5. FXR activation in L cells decreases proglucagon (show GCG Antibodies) expression by interfering with the glucose-responsive factor Carbohydrate-Responsive Element Binding Protein (ChREBP (show MLXIPL Antibodies)) and GLP-1 (show GCG Antibodies) secretion by inhibiting glycolysis.

  6. FXR may regulate SOD3 (show SOD3 Antibodies) expression to suppress reactive oxygen species production, resulting in decreasing JNK (show MAPK8 Antibodies) activity.

  7. ransgenic mice that conditionally and tissue specifically express the activated form of FXR in the liver and intestine showed partial neonatal lethality, growth retardation, and spontaneous liver toxicity.

  8. No evidence for a major role of FXR in acute human or murine pancreatitis. The observed altered Fxr activity during the course of disease may be a secondary phenomenon.

  9. Protective effects of farnesoid X receptor (show xpr1 Antibodies) on hepatic lipid accumulation are mediated by hepatic FXR and are independent of intestinal FGF15 signaling.

  10. The hepatic FXR alpha2 and FXR alpha4 differentially modulate bile salt and lipoprotein metabolism in mice.

Pig (Porcine) Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) interaction partners

  1. alterations in bile acid composition may have contributed to the observed disturbance in FXR-mediated signalling pathways in short bowel syndrome-associated liver disease

  2. FXR splice variant has a dominant positive effect on wild type FXR.

  3. In conclusion, PXR (show NR1I2 Antibodies) and FXR both responded to ligands that activated their human orthologs, and some of the alternatively spliced variants significantly altered PXR (show NR1I2 Antibodies) and FXR transactivation at in vivo expression levels.

Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) Antigen Profile

Antigen Summary

This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Alternative names and synonyms associated with Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4)

  • nuclear receptor subfamily 1, group H, member 4 (nr1h4) antibody
  • nuclear receptor subfamily 1, group H, member 4 (NR1H4) antibody
  • nuclear receptor subfamily 1, group H, member 4 (LOC100219563) antibody
  • nuclear receptor subfamily 1, group H, member 4 (Nr1h4) antibody
  • AI957360 antibody
  • BAR antibody
  • Fxr antibody
  • HRR-1 antibody
  • HRR1 antibody
  • NR1H4 antibody
  • RIP14 antibody
  • Rxrip14 antibody
  • zgc:92742 antibody
  • zgc:110190 antibody

Protein level used designations for NR1H4

nuclear receptor subfamily 1, group H, member 4 , orphan nuclear receptor FOR2 , FXRalpha , bile acid receptor , farnesoid X activated receptor , bile acid receptor-like , RXR-interacting protein 14 , farnesoid X nuclear receptor , farnesoid X-activated receptor , farnesol receptor HRR-1 , retinoid X receptor-interacting protein 14 , nuclear receptor subfamily 1 group H member 4

GENE ID SPECIES
398316 Xenopus laevis
436847 Danio rerio
452162 Pan troglodytes
695618 Macaca mulatta
100019526 Monodelphis domestica
100052821 Equus caballus
100219563 Taeniopygia guttata
100391012 Callithrix jacchus
100587301 Nomascus leucogenys
9971 Homo sapiens
373902 Gallus gallus
612928 Canis lupus familiaris
540528 Bos taurus
100009485 Oryctolagus cuniculus
20186 Mus musculus
60351 Rattus norvegicus
100153960 Sus scrofa
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