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Browse our anti-APAF1 (APAF1) Antibodies

Full name:
anti-Apoptotic Peptidase Activating Factor 1 Antibodies (APAF1)
On www.antibodies-online.com are 202 Apoptotic Peptidase Activating Factor 1 (APAF1) Antibodies from 31 different suppliers available. Additionally we are shipping APAF1 Kits (48) and APAF1 Proteins (7) and many more products for this protein. A total of 265 APAF1 products are currently listed.
Synonyms:
6230400I06Rik, anon-53Fa, APAF-1, apaf1, Apaf1l, arc, ark, CED4, CG6829, D-Apaf-1, dapaf, dapaf-1, dApaf-1/DARK/HAC-1, Dapaf-1/HAC-1, dapaf-1L, dapaf-1S, dApaf1, dark, Dark/Apaf-I, dark/dapaf-1/hac-1, Dark/Dapaf-1/HAC1, dark/hac-1/dapaf-1, Dark/Hac-1/dApaf1, Dmel\\CG6829, fog, hac-1, Hac-1/Dark, hac1, l(2)SH0173, mKIAA0413, T1, zgc:136543
list all antibodies Gene Name GeneID UniProt
APAF1 317 O14727
APAF1 11783 O88879
APAF1 78963 Q9EPV5

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Most Popular Reactivities for anti-APAF1 (APAF1) Antibodies

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anti-Human APAF1 Antibodies:

anti-Mouse (Murine) APAF1 Antibodies:

anti-Rat (Rattus) APAF1 Antibodies:

All available anti-APAF1 Antibodies

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Top referenced anti-APAF1 Antibodies

  1. Human Polyclonal APAF1 Primary Antibody for WB - ABIN967648 : Cecconi, Alvarez-Bolado, Meyer, Roth, Gruss: Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. in Cell 1998 (PubMed)
    Show all 6 references for ABIN967648

  2. Human Monoclonal APAF1 Primary Antibody for IF, WB - ABIN968496 : Cain, Brown, Langlais, Cohen: Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex. in The Journal of biological chemistry 1999 (PubMed)
    Show all 5 references for ABIN968496

  3. Human Monoclonal APAF1 Primary Antibody for EIA, IHC (fro) - ABIN400811 : Zou, Henzel, Liu, Lutschg, Wang: Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. in Cell 1997 (PubMed)
    Show all 4 references for ABIN400811

  4. Human Polyclonal APAF1 Primary Antibody for EIA, IHC (p) - ABIN499289 : Li, Nijhawan, Budihardjo, Srinivasula, Ahmad, Alnemri, Wang: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. in Cell 1997 (PubMed)
    Show all 4 references for ABIN499289

  5. Cow (Bovine) Polyclonal APAF1 Primary Antibody for WB - ABIN222876 : Dirks, Leeuwenburgh: Apoptosis in skeletal muscle with aging. in American journal of physiology. Regulatory, integrative and comparative physiology 2002 (PubMed)
    Show all 4 references for ABIN222876

  6. Human Polyclonal APAF1 Primary Antibody for EIA, IHC (p) - ABIN499287 : Hu, Benedict, Wu, Inohara, Núñez: Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. in Proceedings of the National Academy of Sciences of the United States of America 1998 (PubMed)
    Show all 4 references for ABIN499287

More Antibodies against APAF1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Apoptotic Peptidase Activating Factor 1 (APAF1) interaction partners

  1. polyglutamine-induced cell death was dramatically suppressed in flies lacking Dark, the fly homolog of human Apaf-1, a key regulator of apoptosis

  2. structural analysis of Apaf-1 in the auto-inhibited form demonstrates the critical role of ADP [review]

  3. ARK is essential for apoptosis during D. melanogaster development, and for radiation-induced apoptosis. Ark mutant embryos have extra cells, and tissues such as brain lobes and wing discs are enlarged.

  4. Daxx (show DAXX Antibodies)-like protein of Drosophila interacts with Dmp53 and affects longevity and Ark mRNA level

Human Apoptotic Peptidase Activating Factor 1 (APAF1) interaction partners

  1. miR21 is transferred from cancer-associated adipocytes (CAAs) and fibroblasts (CAFs (show TBX1 Antibodies)) to the cancer cells, where it suppresses ovarian cancer apoptosis and confers chemoresistance by binding to its direct novel target, APAF1.

  2. HDAC (show HDAC3 Antibodies) inhibitors can induce p53 (show TP53 Antibodies) acetylation at lysine 120, which in turn enhances mitochondrion-mediated apoptosis through transcriptional up-regulation of Apaf-1.

  3. Renal APAF1 expression is increased in diabetes and diabetic nephropathy.

  4. Inhibition of Caspase-9 restricted, while Apaf-1 promoted, Chlamydia pneumoniae infection in HEp-2, HeLa, and mouse epithelial fibroblast (MEF) cells.

  5. These results suggest that CED-4 forms a complex with ced-3 mRNA and delivers it to ribosomes for translation.

  6. The auto-assembly of truncated Apaf1 molecules disappeared after several hours without any enzyme activation.

  7. cytochrome c (show CYCS Antibodies) and the WD domains of Apaf-1 interact, with bifurcated salt bridges involved in apoptosome assembly

  8. NF-kappaB (show NFKB1 Antibodies) response element, located close to the p53RE#1, mediates APAF1 transcriptional repression by affecting interaction between KAISO (show ZBTB33 Antibodies) and p53 (show TP53 Antibodies)

  9. This study suggested that miR (show MLXIP Antibodies)-23a, acting as an oncogenic regulator by directly targeting APAF1 in pancreatic cancer, is a useful potential biomarker in diagnosis and treatment of pancreatic cancer.

  10. Our results indicate that the APAF1, BAX (show BAX Antibodies), and FLASH genes not only harbor frameshift mutations but also demonstrate mutational ITH, which together might play a role in the tumorigenesis of CRC (show CALR Antibodies) with MSI (show MSI1 Antibodies)-H by affecting the apoptosis of cancer cells.

Mouse (Murine) Apoptotic Peptidase Activating Factor 1 (APAF1) interaction partners

  1. Apaf1's pivotal role during embryonic development as has been demonstrated to be in regulation of neuronal cell death

  2. Inhibition of Caspase-9 restricted, while Apaf-1 promoted, Chlamydia pneumoniae infection in HEp-2, HeLa, and mouse epithelial fibroblast (MEF) cells.

  3. Apaf1 is required for proper cortical neuron differentiation since its deletion specifically impairs axonal outgrowth.

  4. study demonstrates that MMP-3 (show MMP3 Antibodies) leads to caspase-9 (show CASP9 Antibodies) activation and suggests that this occurs indirectly via a cytosolic protein, possibly involving Apaf-1

  5. results provide evidence that Apaf-1 pharmacological inhibition has therapeutic potential for the treatment of apoptosis-related diseases.

  6. Study reports experimental evidence suggesting the likely participation of the Apaf1 protein in the aggregation of polyQ stretches; Apaf1 may enhance polyglutamine aggregation by reducing the cellular protein levels of available functional Hsp70 (show HSP70 Antibodies)

  7. miR (show MLXIP Antibodies)-23a/b and miR (show MLXIP Antibodies)-27a/b are endogenous inhibitory factors of Apaf-1 expression and regulate the sensitivity of neurons to apoptosis.

  8. a role for Apaf1 at the mitochondria

  9. The Apaf-1-independent caspase (show CASP3 Antibodies) activation was not inhibited by Bcl-2 (show BCL2 Antibodies), and occurred without the release of cytochrome c (show CYCS Antibodies) from mitochondria, suggesting that the mitochondrial pathway was not involved in this death process.

  10. These data are consistent with a model in which alterations of GH signaling and/or insulin (show INS Antibodies) sensitivity lead to increased lifespan mediated by decreased renal expression of pro-apoptotic genes.

Pig (Porcine) Apoptotic Peptidase Activating Factor 1 (APAF1) interaction partners

  1. Counterpulsation could protect vascular endothelial cells from apoptosis, delaying early atherosclerotic lesions possibly through transcriptional down-regulation of pro-apoptotic gene Apaf-1, and up-regulation of anti-apoptotic gene BIRC2 (show BIRC2 Antibodies).

Zebrafish Apoptotic Peptidase Activating Factor 1 (APAF1) interaction partners

  1. results provide evidence that Apaf-1 pharmacological inhibition has therapeutic potential for the treatment of apoptosis-related diseases.

APAF1 Antigen Profile

Antigen Summary

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.

Alternative names and synonyms associated with APAF1

  • Apaf-1-related-killer (Ark) antibody
  • apoptotic peptidase activating factor 1 (apaf1) antibody
  • apoptotic peptidase activating factor 1 (APAF1) antibody
  • apoptotic peptidase activating factor 1 (Apaf1) antibody
  • apoptotic protease activating factor 1 (apaf1) antibody
  • 6230400I06Rik antibody
  • anon-53Fa antibody
  • APAF-1 antibody
  • apaf1 antibody
  • Apaf1l antibody
  • arc antibody
  • ark antibody
  • CED4 antibody
  • CG6829 antibody
  • D-Apaf-1 antibody
  • dapaf antibody
  • dapaf-1 antibody
  • dApaf-1/DARK/HAC-1 antibody
  • Dapaf-1/HAC-1 antibody
  • dapaf-1L antibody
  • dapaf-1S antibody
  • dApaf1 antibody
  • dark antibody
  • Dark/Apaf-I antibody
  • dark/dapaf-1/hac-1 antibody
  • Dark/Dapaf-1/HAC1 antibody
  • dark/hac-1/dapaf-1 antibody
  • Dark/Hac-1/dApaf1 antibody
  • Dmel\\CG6829 antibody
  • fog antibody
  • hac-1 antibody
  • Hac-1/Dark antibody
  • hac1 antibody
  • l(2)SH0173 antibody
  • mKIAA0413 antibody
  • T1 antibody
  • zgc:136543 antibody

Protein level used designations for APAF1

Apaf-1 related , Apaf-1 related killer , Apaf-1-related killer , Ark-PA , Ark-PB , CG6829-PA , CG6829-PB , apaf1-related killer , dark , drosophila Apaf-1-related killer , lethal (2) SH0173 , transcription unit 1 , apoptotic peptidase activating factor 1 , apoptotic protease-activating factor 1-like , apoptotic protease-activating factor 1 , apoptotic protease activating factor 1 , forebrain overgrowth , apaf-1

GENE ID SPECIES
36914 Drosophila melanogaster
444261 Xenopus laevis
100127738 Xenopus (Silurana) tropicalis
452153 Pan troglodytes
694164 Macaca mulatta
768257 Felis catus
100013051 Monodelphis domestica
100459074 Pongo abelii
100464163 Ailuropoda melanoleuca
100549497 Meleagris gallopavo
100556318 Anolis carolinensis
100590369 Nomascus leucogenys
317 Homo sapiens
11783 Mus musculus
78963 Rattus norvegicus
537782 Bos taurus
482620 Canis lupus familiaris
417926 Gallus gallus
100719903 Cavia porcellus
100513283 Sus scrofa
100052552 Equus caballus
100135699 Ovis aries
58131 Danio rerio
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