Browse our anti-IKZF1 (IKZF1) Antibodies

Full name:
anti-IKAROS Family Zinc Finger 1 (Ikaros) Antibodies (IKZF1)
On www.antibodies-online.com are 135 IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) Antibodies from 28 different suppliers available. Additionally we are shipping IKZF1 Kits (7) and IKZF1 Proteins (3) and many more products for this protein. A total of 155 IKZF1 products are currently listed.
Synonyms:
5832432G11Rik, hIk-1, hlk-1, Hs.54452, IK1, ikaros, ikzf1, LyF-1, LYF1, mKIAA4227, PRO0758, RGD1562979, Zfpn1a1, znfn1a1
list all antibodies Gene Name GeneID UniProt
IKZF1 22778  
IKZF1 305501  
IKZF1 10320 Q13422

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anti-Mouse (Murine) IKZF1 Antibodies:

anti-Rat (Rattus) IKZF1 Antibodies:

anti-Human IKZF1 Antibodies:

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Top referenced anti-IKZF1 Antibodies

  1. Human Polyclonal IKZF1 Primary Antibody for EIA, FACS - ABIN952880 : Yang, Luo, Wei: Integrative genomic analyses on Ikaros and its expression related to solid cancer prognosis. in Oncology reports 2010 (PubMed)
    Show all 5 references for 952880

  2. Mouse (Murine) Monoclonal IKZF1 Primary Antibody for ChIPSeq, ChIP - ABIN2668828 : Yeung, Chung, Guess, Bell, Leinwand: Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos. in Nucleic acids research 2012 (PubMed)

  3. Mouse (Murine) Polyclonal IKZF1 Primary Antibody for WB - ABIN2668752 : Zarnegar, Rothenberg: Ikaros represses and activates PU.1 cell-type-specifically through the multifunctional Sfpi1 URE and a myeloid specific enhancer. in Oncogene 2012 (PubMed)

  4. Human Polyclonal IKZF1 Primary Antibody for ELISA, WB - ABIN314228 : Mullighan, Goorha, Radtke, Miller, Coustan-Smith, Dalton, Girtman, Mathew, Ma, Pounds, Su, Pui, Relling, Evans, Shurtleff, Downing: Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. in Nature 2007 (PubMed)

  5. Cow (Bovine) Polyclonal IKZF1 Primary Antibody for WB - ABIN2777317 : Loeper, Asa, Ezzat: Ikaros modulates cholesterol uptake: a link between tumor suppression and differentiation. in Cancer research 2008 (PubMed)

  6. Dog (Canine) Polyclonal IKZF1 Primary Antibody for IHC, WB - ABIN2777569 : Maccarrone, Bari, Di Rienzo, Finazzi-Agrò, Rossi: Progesterone activates fatty acid amide hydrolase (FAAH) promoter in human T lymphocytes through the transcription factor Ikaros. Evidence for a synergistic effect of leptin. in The Journal of biological chemistry 2003 (PubMed)

  7. Human Polyclonal IKZF1 Primary Antibody for FACS, IHC (p) - ABIN654180 : Kuiper, Waanders, van der Velden, van Reijmersdal, Venkatachalam, Scheijen, Sonneveld, van Dongen, Veerman, van Leeuwen, van Kessel, Hoogerbrugge: IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL. in Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2010 (PubMed)

More Antibodies against IKZF1 Interaction Partners

Mouse (Murine) IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) interaction partners

  1. Sumoylated Ikaros is less effective than unsumoylated forms at inhibiting the expansion of murine leukemic cells, and Ikaros sumoylation is abundant in human B-cell acute lymphoblastic leukemic cells, but not in healthy peripheral blood leukocytes. Our results suggest that sumoylation may be important in modulating the tumor suppressor function of Ikaros

  2. our results identify BTG1 as a tumor suppressor in leukemia that, when deleted, strongly enhances the risk of relapse in IKZF1-deleted B-cell precursor acute lymphoblastic leukemia, and augments the glucocorticoid resistance phenotype mediated by the loss of IKZF1 function.

  3. These results indicate that Ikaros is required to limit B1 cell homeostasis in the adult.

  4. These results suggest that Ikaros functions as a negative regulator of follicular B cell activation (show BLNK Antibodies).

  5. Ikaros functions as a guardian of B-1 lymphoid pattern, and that its absence directs the differentiation of B-1 cells into phagocytes.

  6. Ikaros is a fundamental regulator of PRC2 function in developing T cells.

  7. Ikaros/Ets1 binding has a role on Ikzf1 expression that is exerted at least through its promoter

  8. deletions on chromosomes 4 and 11 affecting Cdkn2a (show CDKN2A Antibodies) and Ikaros are a prominent feature of young adult irradiation-induced T-cell lymphoma.. tumors arising after irradiation suffer a second hit in Pten (show PTEN Antibodies) by mis (show AMH Antibodies)-segregation or recombination

  9. Murine pancreatic adenocarcinoma reduces Ikaros expression and disrupts T cell homeostasis

  10. The Ikaros family of DNA-binding proteins are critical regulators of lymphocyte differentiation. (Review)

Human IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) interaction partners

  1. The M4 motif (ACTAYRNNNCCCR) is a functional regulatory bipartite cis (show CISH Antibodies)-element, which engages a THAP11 (show THAP11 Antibodies)/HCF-1 (show HCFC1 Antibodies) complex via binding to the ACTAYR module, while the CCCRRNRNRC subsequence part constitutes a binding platform for Ikaros and NFKB1 (show NFKB1 Antibodies)

  2. Germline heterozygous IKZF1 mutations cause dysgammaglobulinemia, hematologic abnormalities (including B-cell defects), and autoimmune diseases

  3. Results suggest that the rs1456896 A allele is associated with protective susceptibility to lupus nephritis. However, this association did not seem to be implicated in the disease and histopathological severity of lupus nephritis in the current population, a northern Han Chinese cohort.

  4. elevated Ctnnd1 (show CTNND1 Antibodies) expression contributes to maintenance of murine B-ALL cells with compromised Ikaros function.

  5. the presence of IKAROS deletion in acute lymphoblastic leukemia in Mexican Mestizos patients could represent a poor-prognosis marker and was probably related to therapy failure

  6. Sumoylated Ikaros is less effective than unsumoylated forms at inhibiting the expansion of murine leukemic cells, and Ikaros sumoylation is abundant in human B-cell acute lymphoblastic leukemic cells, but not in healthy peripheral blood leukocytes. Our results suggest that sumoylation may be important in modulating the tumor suppressor function of Ikaros

  7. our results identify BTG1 as a tumor suppressor in leukemia that, when deleted, strongly enhances the risk of relapse in IKZF1-deleted B-cell precursor acute lymphoblastic leukemia, and augments the glucocorticoid resistance phenotype mediated by the loss of IKZF1 function.

  8. ETV6 (show ETV6 Antibodies) and IKZF1 are transcriptional regulators not just of ERG (show ERG Antibodies), but also of a number of genes regulated by a densely interconnected network of seven transcription factors.

  9. results suggest that CRBN (show CRBN Antibodies) binds to Ikaros via its N-terminal region and regulates transcriptional activities of Ikaros and its downstream target, enkephalin

  10. revealed more than 170 NFAT (show NFATC1 Antibodies)-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 (show NFATC1 Antibodies) and NFATc2 (show NFAT1 Antibodies) in T cells, such as Raptor (show RPTOR Antibodies), CHEK1 (show CHEK1 Antibodies), CREB1 (show CREB1 Antibodies), RUNX1 (show RUNX1 Antibodies), SATB1 (show SATB1 Antibodies), Ikaros, and Helios (show ZNFN1A2 Antibodies).

IKZF1 Antigen Profile

Antigen Summary

This gene encodes a transcription factor that belongs to the family of zinc-finger DNA binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. All isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homodimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and contain the nuclear localization signal, resulting in members with and without DNA-binding properties. Only few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and thought to function as dominant negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).

Alternative names and synonyms associated with IKZF1

  • IKAROS family zinc finger 1 (Ikzf1) antibody
  • IKAROS family zinc finger 1 (Ikaros) (IKZF1) antibody
  • IKAROS family zinc finger 1 (Ikaros) (ikzf1) antibody
  • Ikaros homolog (ikaros) antibody
  • 5832432G11Rik antibody
  • hIk-1 antibody
  • hlk-1 antibody
  • Hs.54452 antibody
  • IK1 antibody
  • ikaros antibody
  • ikzf1 antibody
  • LyF-1 antibody
  • LYF1 antibody
  • mKIAA4227 antibody
  • PRO0758 antibody
  • RGD1562979 antibody
  • Zfpn1a1 antibody
  • znfn1a1 antibody

Protein level used designations for IKZF1

DNA-binding protein Ikaros , ikaros family zinc finger protein 1 , lymphoid transcription factor LyF-1 , zinc finger protein subfamily 1A, 1 , zinc finger protein, subfamily 1A, 1 (Ikaros) , CLL-associated antigen KW-6 , Ikaros (zinc finger protein) , Ikaros transcription factor , KAROS family zinc finger 1 (Ikaros)

GENE ID SPECIES
22778 Mus musculus
305501 Rattus norvegicus
10320 Homo sapiens
395974 Gallus gallus
483231 Canis lupus familiaris
541154 Bos taurus
30177 Danio rerio
100136762 Oncorhynchus mykiss
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