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Human Interleukin 33 Protein expressed in Escherichia coli (E. coli) - ABIN1344110
Iikura, Suto, Kajiwara, Oboki, Ohno, Okayama, Saito, Galli, Nakae: IL-33 can promote survival, adhesion and cytokine production in human mast cells. in Laboratory investigation; a journal of technical methods and pathology 2007
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Human Interleukin 33 Protein expressed in Escherichia coli (E. coli) - ABIN1343983
Suzukawa, Iikura, Koketsu, Nagase, Tamura, Komiya, Nakae, Matsushima, Ohta, Yamamoto, Yamaguchi: An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor. in Journal of immunology (Baltimore, Md. : 1950) 2008
Show all 2 Pubmed References
Human Interleukin 33 Protein expressed in Escherichia coli (E. coli) - ABIN2002684
Cayrol, Girard: The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1. in Proceedings of the National Academy of Sciences of the United States of America 2009
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serum levels determined of both T cell polarizing (IL- 33 and IL-12 (show IL12A Proteins)) and T cell effector (IFN-gamma (show IFNG Proteins), IL-4 (show IL4 Proteins), IL-10 (show IL10 Proteins), IL-17 (show IL17A Proteins) and IL-9 (show IL9 Proteins)) cytokines in T1DM (type-1 Diabetes Mellitus) subjects with and without microvascular complications (MVC). All the tested cytokines were significantly elevated in T1DM subjects except for IFN-gamma (show IFNG Proteins) with no significant difference between those with and withodifference between those with and wi...
Study demonstrates that IL-33 and ST2 are highly expressed by various central nervous system (CNS) resident cells, and there was a change of the expression levels and patterns of both molecules in the CNS lesions of multiple sclerosis (MS)patients compared with healthy brain tissues. Furthermore, IL-33/ST2 signaling pathway may have its unique important function in the myelination process in the CNS compartment.
TGF-beta1 also suppressed the combined effects of IL (show TGFB1 Proteins)-33 and IgE-mediated activation on mouse and human mast cells. Th (show TNF Proteins)e role (show IL6 Proteins) of IL- (show IL13 Proteins)33 in the p (show CCL2 Proteins)athogenesis of allergic diseases is incompletel (show TGFB1 Proteins)y understood. These findings, (show AKT1 Proteins) demonst (show EPHB2 Proteins)rate that TGF-beta1 can provide broad (show NFKB1 Proteins) inhibitor (show FOSB Proteins)y signals to activated mast cells.
IL-33-induced MMP-9 (show MMP9 Proteins) expression in the mouse monocyte/macrophage line RAW264.7.
LTR-IL-33 expression is required for optimal CRC (show CALR Proteins) cell line growth
Taken together, the present study indicates that IL-33 localized in the human atherosclerotic plaque increases GRO-alpha mRNA expression and protein secretion via activation of ERK1/2, JNK (show MAPK8 Proteins), and NF-kappaB (show NFKB1 Proteins) in HUVECs, suggesting that IL-33 plays an important role in the pathophysiology and development of atherosclerosis.
These data suggest that plasmacytoid dendritic cells producing IFN-alpha (show IFNA Proteins) and IL-33 play a pivotal role in the chronic fibro-inflammatory responses underlying murine autoimmune pancreatitis and human IgG4-related autoimmune pancreatitis.
Data provide evidence that increased IL-33/ST2 levels in patients with chronic kidney disease are an indicator of increased inflammation, impaired endothelial functions, and cardiovascular events.
Incresed expression of IL-33 in colorectal cancer cells enhanced their tumor take, growth, and liver metastasis.
Serum levels of IL-33 were positively correlated with cognitive performance in patients with Schizophrenia.
IL-33 promoted the new extracellular matrix deposition and angiogenesis formation, which indicates an important role of IL-33 on matrix synthesis and neovascularization.
Data indicate that interleukin-33 (IL-33)-induced Interleukin-13 (IL-13 (show IL13 Proteins)) production by type-2 helper T cells (Th2 cells) Is dependent on epidermal growth factor receptor (EGFR (show EGFR Proteins)) expression.
Heligmosomoides polygyrus Alarmin Release Inhibitor (HpARI) prevents binding of active interleukin-33 (IL-33) to the IL-33 receptor.
Despite its expression in the synovium of arthritic mice and normal keratinocytes, IL-33 is not required for collagen-induced arthritis development in arthritis or psoriasis
The studies establish chronic pancreatitis as an IL-33-dependent inflammation resulting from synergistic interactions between the NOD1 (show NOD1 Proteins) and CCKR signaling pathways.
study concludes that IL-33 and TSLP (show TSLP Proteins) are required for epithelial cell IL-25 (show IL25 Proteins) expression, mucous metaplasia, and ILC2 expansion following early-life rhinovirus infection
Bone marrow-derived mast cells cultured in TGF-beta1 (show TGFB1 Proteins), beta2, or beta3 showed reduced IL-33-mediated production of TNF (show TNF Proteins), IL-6 (show IL6 Proteins), IL-13 (show IL13 Proteins), and MCP-1 (show CPT1B Proteins) in a concentration-dependent manner. TGF-beta1 (show TGFB1 Proteins) inhibited IL-33-mediated Akt (show AKT1 Proteins) and ERK (show EPHB2 Proteins) phosphorylation as well as NF-kappaB (show NFKB1 Proteins)- and AP-1 (show JUN Proteins)-mediated transcription.
results suggest that EGF is a key growth factor that increased IL-33 production and ST2 receptor expression during intestinal inflammation and carcinogenesis; the EGF/IL-33/ST2 axis represents a novel therapeutic target in colon cancer
Lactic Acid Suppresses IL-33-Mediated Mast Cell Inflammatory Responses via Hypoxia-Inducible Factor-1alpha-Dependent miR (show MLXIP Proteins)-155 Suppression
Liver Treg cells show a high expression of ST2 (show SULT2A1 Proteins), a cellular receptor for tissue alarmin IL-33, which is strongly upregulated in the liver of infected mice. These results illustrate the importance of IL-33 in the suppressive function of liver Treg cells during Cytomegaloviruses (CMVs) infection.
IL-33 may be a key molecule operating in eosinophil-mediated fibrosis in high-dose-per fraction irradiated skin.
IL33 (MIM 608678) is a member of the IL1 (see MIM 147760) family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL4\; MIM 147780). IL33 is a ligand for IL33R (IL1RL1\; MIM 601203), an IL1 family receptor that is selectively expressed on Th2 cells and mast cells (summary by Yagami et al., 2010
, DVS27-related protein
, interleukin-1 family member 11
, nuclear factor for high endothelial venules
, nuclear factor from high endothelial venules