CD130/gp130 Protein (AA 23-617) (Fc Tag)
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- Target See all CD130/gp130 (IL6ST) Proteins
- CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 23-617
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This CD130/gp130 protein is labelled with Fc Tag.
- Sequence
- AA 23-617
- Characteristics
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 93.3 kDa. The protein migrates as 120-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Purity
- >90 % as determined by SDS-PAGE.
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product IL6ST Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Tris with Glycine, Arginine and NaCl, pH 7.5
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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- Target
- CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))
- Alternative Name
- Gp130 (IL6ST Products)
- Synonyms
- CD130 Protein, CDW130 Protein, GP130 Protein, IL-6RB Protein, 5133400A03Rik Protein, AA389424 Protein, BB405851 Protein, D13Ertd699e Protein, gp130 Protein, Ac1055 Protein, Gp130 Protein, Il-6rb Protein, IL-6 Protein, interleukin 6 signal transducer Protein, IL6ST Protein, Il6st Protein, il6st Protein
- Background
- Interleukin-6 receptor subunit beta (IL6ST) is also known as IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130 (gp130), CD130, Oncostatin-M receptor subunit alpha and Il6st,which is single-pass type I membrane protein. IL6ST /gp130 /CD130 can be found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver and found in all the cell lines tested except BaF-B03.The expression of IL-6ST /gp130 is not restricted to IL6-responsive cells. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. IL6ST /CD130 can bind to IL6 /IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduce the signal. IL6ST /GP130 does not bind IL6 and may have a role in embryonic development.
- Molecular Weight
- 93.3 kDa
- NCBI Accession
- NP_034690
- Pathways
- JAK-STAT Signaling, Cellular Glucan Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Cancer Immune Checkpoints
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