WFS1 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)
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- Target See all WFS1 Proteins
- WFS1 (Wolfram Syndrome 1 (WFS1))
- Protein Type
- Recombinant
- Protein Characteristics
- Transcript Variant 1
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This WFS1 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human Wolframin / WFS1 (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product WFS1 Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- WFS1 (Wolfram Syndrome 1 (WFS1))
- Alternative Name
- Wolframin,wfs1 (WFS1 Products)
- Synonyms
- WFRS Protein, WFS Protein, WFSL Protein, CG4917 Protein, Dmel\\CG4917 Protein, GB15257 Protein, WFS1 Protein, AI481085 Protein, wolframin Protein, wfs1 Protein, wolframin ER transmembrane glycoprotein Protein, wolfram syndrome 1 Protein, wolframin Protein, Wolfram syndrome 1 (wolframin) L homeolog Protein, Wfs1 Protein, WFS1 Protein, wfs1 Protein, LOC552818 Protein, CpipJ_CPIJ013087 Protein, wfs1.L Protein
- Background
- This gene encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations in this gene are associated with Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), an autosomal recessive disorder. The disease affects the brain and central nervous system. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. Alternatively spliced transcript variants have been found for this gene.
- Molecular Weight
- 100.1 kDa
- NCBI Accession
- NP_005996
- Pathways
- Sensory Perception of Sound, Carbohydrate Homeostasis, ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interactome
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