CRTAM Protein (AA 18-287) (Fc Tag)
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- Target See all CRTAM Proteins
- CRTAM (Cytotoxic and Regulatory T Cell Molecule (CRTAM))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 18-287
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Origin
- Cynomolgus
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This CRTAM protein is labelled with Fc Tag.
- Sequence
- AA 18-287
- Characteristics
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 56.6 kDa. The protein migrates as 85-95 kDa under reducing (R) condition (SDS-PAGE).
- Purity
- >90 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product CRTAM Protein
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Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-287) protein (Fc Tag)
CRTAM Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-287) protein (His tag)CRTAM Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-287) protein (His tag)CRTAM Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 17-289) protein (His tag)CRTAM Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-287) protein (His tag)CRTAM Origin: Dog Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 1-393) protein (GST tag)CRTAM Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Tris with Glycine, Arginine and NaCl, pH 7.5
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
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- Target
- CRTAM (Cytotoxic and Regulatory T Cell Molecule (CRTAM))
- Alternative Name
- CRTAM (CRTAM Products)
- Synonyms
- TAD Protein, cTADS Protein, MGC82176 Protein, CRTAM Protein, CD355 Protein, cytotoxic and regulatory T-cell molecule Protein, cytotoxic and regulatory T-cell molecule L homeolog Protein, cytotoxic and regulatory T cell molecule Protein, CRTAM Protein, crtam.L Protein, Crtam Protein
- Background
- Class I-restricted T cell-associated molecule (CRTAM), a member of nectin family and the immunoglobulin superfamily, is also known as cytotoxic and regulatory T-cell molecule, which is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and surprisingly, in brain where it is highly expressed by Purkinje cells of the cerebellum. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions (3 - 5). IGSF4 and T cell receptor co-engagement of CRTAM-expressing CD8+ cells induces increased IFN-gamma or IL-22 production (3, 4). Furthermore, a role in cancer surveillance through NK cell-mediated rejection of IGSF4-expressing tumors has been proposed.
- Molecular Weight
- 56.6 kDa
- NCBI Accession
- XP_005580021
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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