SNCA Protein

Catalog No. ABIN934870

Product Details

Target: SNCA (Synuclein, alpha (SNCA))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Sequence: MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA

Characteristics: Purified recombinant Human alpha Synuclein protein
Expression System: E.coli
Molecular weight on SDS-PAGE will appear higher.

Purity: > 95 % pure

Sterility: 0.2 μm filtered

Endotoxin Level: < 1.0 EU per µg of protein (determined by LAL method)

Application Details

Application Notes: Alpha synuclein protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in sterile distilled water at a concentration of 1 mg/mL or less.

Concentration: 1 mg/mL

Buffer: Lyophilized from a 0.2 µm filtered in 20 mM Tris-HCl buffer, pH 7.5, containing 100 mM NaCl, and 0 mM MgCl2.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: RT/-20 °C

Storage Comment: The product is shipped at ambient temperature. Upon receipt, store it immediately at 4 °C in the short term (1 month). For long term storage, aliquot and store at -20 °C or -70 °C.

Target Details

Target: SNCA (Synuclein, alpha (SNCA))

Alternative Name: alpha Synuclein (SNCA Products)

Synonyms: snca Protein, MGC64356 Protein, LOC619283 Protein, NACP Protein, alphaSYN Protein, PARK1 Protein, PARK4 Protein, PD1 Protein, synuclein alpha L homeolog Protein, alpha-synuclein Protein, synuclein alpha Protein, synuclein, alpha Protein, snca.L Protein, LOC619283 Protein, SNCA Protein, Snca Protein

Background: Alpha-Synuclein, an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. alpha-synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Moreover, recent studies have shown that alpha-synuclein has chaperone activity and that this activity is lost upon removing its C-terminal acidic tail (amino acids 96-140).
Alternative Names: alphaSYN protein, SNCA protein, Non-A beta component of AD amyloid protein, PARK1 protein, , Non-A4 component of amyloid precursor protein, Synuclein alpha protein, MGC64356 protein, PARK 4 protein, Non-A-beta component of alzheimers disease amyloid protein, MGC127560 protein, Non A beta component of AD amyloid protein, Parkinson disease familial 1 protein, Non A4 component of amyloid precursor protein, alpha-Synuclein protein, MGC110988 protein, NACP protein, Alpha-synuclein isoform NACP140 protein, PD1 protein, precursor of PARK 1 protein, MGC105443 protein, Alpha synuclein protein, PD 1 protein, PARK4 protein

Molecular Weight: 14.4 kDa (140 AA)

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity