GDF15 Protein
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- Target See all GDF15 Proteins
- GDF15 (Growth Differentiation Factor 15 (GDF15))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- CHO Cells
- Sequence
- ARNGDHCPLG PGRCCRLHTV RASLEDLGWA DWVLSPREVQ VTMCIGACPS QFRAANMHAQ IKTSLHRLKP DTVPAPCCVP ASYNPMVLIQ KTDTGVSLQT YDDLLAKDCH CI
- Characteristics
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Purified recombinant Human GDF15 protein
Expression System: Cell culture
Bioactivity: Determined by a cell inhibition assay using DU-145 cells. The expected ED50 for this effect is 1.0-2.0 µg/mL. - Purity
- > 98 % pure
- Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
- Top Product
- Discover our top product GDF15 Protein
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Growth Differentiation Factor 15 (GDF15) (AA 197-308) protein (His tag)
GDF15 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE
Growth Differentiation Factor 15 (GDF15) (AA 197-308) protein (Fc Tag)GDF15 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Growth Differentiation Factor 15 (GDF15) (AA 189-303) protein (Fc Tag)GDF15 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Growth Differentiation Factor 15 (GDF15) (AA 197-308) protein (Fc Tag,Biotin)GDF15 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Growth Differentiation Factor 15 (GDF15) (AA 189-303) protein (His tag)GDF15 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE
Growth Differentiation Factor 15 (GDF15) (AA 197-308) protein (Fc Tag)GDF15 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 92 % as determined by HPLC
Growth Differentiation Factor 15 (GDF15) (AA 193-308) protein (His tag)GDF15 Origin: Cynomolgus Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE
Growth Differentiation Factor 15 (GDF15) (AA 197-307) protein (His tag)GDF15 Origin: Dog Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE
Growth Differentiation Factor 15 (GDF15) (AA 189-303) protein (Fc Tag,Biotin)GDF15 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Growth Differentiation Factor 15 (GDF15) (AA 197-308) protein (Fc Tag,Biotin)GDF15 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute in water to a concentration of 0.1 - 1.0 mg/mL.
- Buffer
- Lyophilized from 10 mM Sodium Citrate, pH 3.0.
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- Target
- GDF15 (Growth Differentiation Factor 15 (GDF15))
- Alternative Name
- GDF15 (GDF15 Products)
- Synonyms
- GDF15 Protein, GDF-15 Protein, MIC-1 Protein, MIC1 Protein, NAG-1 Protein, PDF Protein, PLAB Protein, PTGFB Protein, SBF Protein, growth differentiation factor 15 Protein, GDF15 Protein, Gdf15 Protein
- Background
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GDF-15 belongs to the TGF beta cytokine family whose members play an important role during prenatal development and postnatal growth, remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in placenta and to a much lesser extent in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest a role for GDF-15 in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers.
Alternative Names: GDF 15, GDF 15 protein, GDF15, GDF-15 protein, GDF-15, GDF-15 protein, Prostate differentiation factor protein, MIC-1 protein, Placental TGFbeta protein - Pathways
- SARS-CoV-2 Protein Interactome
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