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NOV Protein (full length)

NOV Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % pure Active
Catalog No. ABIN935685
  • Target See all NOV Proteins
    NOV (Nephroblastoma Overexpressed (NOV))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    full length
    Origin
    • 5
    • 3
    • 2
    • 1
    • 1
    Human
    Source
    • 4
    • 3
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Sequence
    MQVAATQRCP PQCPGRCPAT PPTCAPGVRA VLDGCSCCLV CARQRGESCS DLEPCDESSG LYCDRSADPS NQTGICTAVE GDNCVFDGVI YRSGEKFQPS CKFQCTCRDG QIGCVPRCQL DVLLPEPNCP APRKVEVPGE CCEKWICGPD EEDSLGGLTL AAYRPEATLG VEVSDSSVNC IEQTTEWTAC SKSCGMGFST RVTNRNRQCE MLKQTRLCMV RPCEQEPEQP TDKKGKKCLR TKKSLKAIHL QFKNCTSLHT YKPRFCGVCS DGRCCTPHNT KTIQAEFQCS PGQIVKKPVM VIGTCTCHTN CPKNNEAFLQ ELELKTTRGK M
    Characteristics
    Purified recombinant Human NOV protein
    Expression System: E.coli
    Bioactivity: Determined by a cell proliferation assay using BALB/c 3T3 cells. The expected ED50 for this effect is 1.0-2.0 µg/mL
    Purity
    > 95 % pure
    Endotoxin Level
    < 0.1 ng per µg (1 EU/µg).
    Top Product
    Discover our top product NOV Protein
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Supplied as a lyophilized powder.
    Handling Advice
    Avoid repeated freeze/thaw cycles.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
  • Target
    NOV (Nephroblastoma Overexpressed (NOV))
    Alternative Name
    NOV (NOV Products)
    Synonyms
    CCN3 Protein, IBP-9 Protein, IGFBP-9 Protein, IGFBP9 Protein, NOVh Protein, nov-A Protein, xnov Protein, NovH Protein, C130088N23Rik Protein, nephroblastoma overexpressed Protein, nephroblastoma overexpressed L homeolog Protein, nephroblastoma overexpressed gene Protein, NOV Protein, nov.L Protein, Nov Protein
    Background
    NOV is a member of the CCN family of secreted cysteine rich regulatory proteins. The full length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities. Elevated expression of NOV is associated with certain tumors, including Wilm's tumor and most nephroblastomas. However, in other tumor types and certain cancer cell lines, increased tumorgenicity and proliferation is correlated with decreased NOV expression. Additionally, NOV induces cell adhesion and cell migration by signaling through specific cell surface integrins and by binding to heparin sulfate proteoglycans and to fibulin 1C. NOV has also been reported to exert proangiogenic activities.
    Alternative Names: Nephroblastoma Overexpressed gene protein, CCN3 protein, NovH protein, IGFBP9 protein
    Molecular Weight
    36.2 kDa
    Pathways
    Smooth Muscle Cell Migration, Growth Factor Binding
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