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anti-Mouse (Murine) alpha Actinin 4 Antibodies:
anti-Rat (Rattus) alpha Actinin 4 Antibodies:
anti-Human alpha Actinin 4 Antibodies:
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Cow (Bovine) Polyclonal alpha Actinin 4 Primary Antibody for IHC, WB - ABIN2775288
Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006
Show all 3 Pubmed References
Human Monoclonal alpha Actinin 4 Primary Antibody for ELISA, FACS - ABIN261463
Koo, Apte: Cell-surface processing of the metalloprotease pro-ADAMTS9 is influenced by the chaperone GRP94/gp96. in The Journal of biological chemistry 2009
Human Monoclonal alpha Actinin 4 Primary Antibody for IF, IHC (p) - ABIN559759
Yamada, Yanamoto, Yoshida, Yoshitomi, Kawasaki, Mizuno, Nemoto: RNAi-mediated down-regulation of alpha-actinin-4 decreases invasion potential in oral squamous cell carcinoma. in International journal of oral and maxillofacial surgery 2010
Human Polyclonal alpha Actinin 4 Primary Antibody for ICC, IF - ABIN4279711
Stadler, Hjelmare, Neumann, Jonasson, Pepperkok, Uhlén, Lundberg: Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. in Journal of proteomics 2012
Cow (Bovine) Polyclonal alpha Actinin 4 Primary Antibody for WB - ABIN2775289
Kimura, Wakamatsu, Suzuki, Ota, Nishikawa, Yamashita, Yamamoto, Sekine, Tsuritani, Wakaguri, Ishii, Sugiyama, Saito, Isono, Irie, Kushida, Yoneyama, Otsuka, Kanda, Yokoi, Kondo, Wagatsuma, Murakawa et al.: Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. ... in Genome research 2006
Show all 2 Pubmed References
ACTN4 is a transcriptional coactivator of NF-kappaB (show NFKB1 Antibodies).
UCHL1 (show UCHL1 Antibodies) upregulation in ACTN4-associated FSGS.
sLZIP negatively regulates skeletal muscle differentiation via interaction with ACTN4.
the C-terminal tail of alpha-actinin-4 is essential for its function in cell migration and adhesion to substratum.
Dexamethasone mey protect actin cytoskeleton stabilization from adriamycin-induced podocyte injury via alpha-actinin-4.
anti-dsDNA Fab (show FANCB Antibodies) may enhance F-actin formation by the proprietary modification of alpha-actinin-4
Together, these results indicate that alpha-actinin (show ACTN1 Antibodies) and the actin cytoskeleton are important components of the cisternal organelle that are probably required to stabilize the AIS (show AR Antibodies).
Results suggest that ACTN4 is essential for maintaining normal spreading, motility, cellular and nuclear cross-sectional area, and contractility of lung fibroblasts by maintaining the balance between transcellular contractility and cell-adhesion.
newly developed mouse model of ACTN4-associated FSGS suggests a cause-and-effect relationship between actin cytoskeleton dysregulation by mutant alpha-actinin-4 and the deterioration of the nephrin (show NPHS1 Antibodies)-supported slit diaphragm complex.
nonsarcomeric alpha-actinin-4 is involved in the regulation of cell movement
Our findings indicate that ACTN4 promotes EMT (show ITK Antibodies) and tumorigenesis by regulating Snail (show SNAI1 Antibodies) expression and the Akt (show AKT1 Antibodies) pathway in cervical cancer. We propose a novel mechanism for EMT (show ITK Antibodies) and tumorigenesis in cervical cancer.
Study found a functional Validation of an Alpha-Actinin-4 Mutation as a Potential Cause of an Aggressive Presentation of Adolescent Focal Segmental Glomerulosclerosis.
SERPINE1 (show SERPINE1 Antibodies), ANGPLT4, CCL20 (show CCL20 Antibodies), and SAA1 (show SAA1 Antibodies) as well as the NF-kappaB (show NFKB1 Antibodies) (p65 (show GORASP1 Antibodies)) binding sites on GR-transrepressed promoters such as IL-1beta (show IL1B Antibodies), IL-6 (show IL6 Antibodies), and IL-8 (show IL8 Antibodies) Taken together, our data establish ACTN4 as a transcriptional co-regulator that modulates both dexamethasone-transactivated and -transrepressed genes in podocytes.
Here, we report the identification of a novel, disease-causing ACTN4 mutation (p.G195D, de novo) in a sporadic case of childhood FSGS using next generation sequencing.
the calmodulin domain of human alpha-actinin-4 binding to the linker region was important for regulating the distance between actin and actin-binding domain.
This study identified alpha-actinin-4 as a novel NHERF1 (show SLC9A3R1 Antibodies) interaction partner and provided new insights into the regulatory mechanism of the actin cytoskeleton by NHERF1 (show SLC9A3R1 Antibodies).
Selective regulation of NF-kappaB (show NFKB1 Antibodies) gene targets may indicate involvement of ACTN4 in determining the specificity of cell response to NF-kappaB (show NFKB1 Antibodies) activation in cells of different types. (Review)
ZYX (show ZYX Antibodies) defective binding to ACTN4, which occupies focal adhesions instead of ACTN1 (show ACTN1 Antibodies), induces the formation of immature focal adhesions, resulting in the enhancement of cell motility and invasion.
The contribution of ACTN4 to the process of lung cancer metastasis to the brain could be mainly through regulation of actin cytoskeleton reorganization, cell motility, and focal adhesion.
SLK (show FYN Antibodies) interacts with Tpr and alpha-actinin-4 in cells, and these protein-protein interactions may control the subcellular localization and the biological activity of SLK (show FYN Antibodies).
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
actinin, alpha 4
, F-actin cross-linking protein
, non-muscle alpha-actinin 4
, alpha actinin 4
, actinin alpha4 isoform
, focal segmental glomerulosclerosis 1