This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This CHRNA9 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 8-42 amino acids from the N-terminal region of human CHRNA9.
CHRNA9
Reactivity: Human, Dog
WB, ELISA
Host: Rabbit
Polyclonal
unconjugated
Application Notes
WB: 1:1000. FC: 1:25
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ..." in: Nature, Vol. 434, Issue 7034, pp. 724-31, (2005) (PubMed).
Peng, Ferris, Matthews, Hiel, Lopez-Albaitero, Lustig: "Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes." in: Life sciences, Vol. 76, Issue 3, pp. 263-80, (2004) (PubMed).
Lustig, Peng: "Chromosome location and characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) gene." in: Cytogenetic and genome research, Vol. 98, Issue 2-3, pp. 154-9, (2003) (PubMed).
Sgard, Charpantier, Bertrand, Walker, Caput, Graham, Bertrand, Besnard: "A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit." in: Molecular pharmacology, Vol. 61, Issue 1, pp. 150-9, (2001) (PubMed).
Nguyen, Ndoye, Grando: "Novel human alpha9 acetylcholine receptor regulating keratinocyte adhesion is targeted by Pemphigus vulgaris autoimmunity." in: The American journal of pathology, Vol. 157, Issue 4, pp. 1377-91, (2000) (PubMed).
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion.