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When compared with SAP (show APCS Proteins), the other single SH2 domain protein in human, EAT2 shows similar binding energies to unphosphorylated ligands. This is inconsistent to the previous data showing low affinity of EAT2 toward unphosphorylated peptides compared to SAP (show APCS Proteins) which shows high affinity
Data indicate that Ewing's sarcoma-associated transcript-2 (EAT-2) over-expression increased the anti-tumor activity of NK cells against K562 tumor cell. targets.
EAT-2 mediates its effects in natural killer cells by linking SLAM (show SLAMF1 Proteins) family receptors to phospholipase Cgamma, calcium fluxes, and Erk (show EPHB2 Proteins) kinase.
NTB-A-mediated IFN-gamma production was greatly reduced in the absence of SLAM-associated protein (SAP), demonstrating that cytokine production and cytotoxicity are differentially dependent on SAP and possibly EAT-2
EAT-2 negatively regulates cytokine production in dendritic cells downstream of SLAM (show SLAMF1 Proteins) engagement and a genetic polymorphism that disturbs this process promotes the development of lupus.
EAT-2A and EAT-2B act as positive regulators of signaling lymphocyte activation molecule (show SLAMF1 Proteins) family receptor-specific NK cell functions in C57BL/6 mice.
Taken together, the data suggest that both EAT-2A and EAT-2B are adapters that recruit Src (show SRC Proteins) kinases to SLAM (show SLAMF1 Proteins) family receptors using a mechanism that is distinct from that of SAP (show APCS Proteins).
EAT-2 mediates CRACC (show SLAMF7 Proteins) function. In the absence of EAT-2, CRACC (show SLAMF7 Proteins) inhibited natural killer cell function.
By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001
SH2 domain protein 1B1
, SH2 domain containing 1B
, SH2 domain-containing protein 1B
, EWS/FLI1-activated transcript 2
, SH2 domain-containing molecule EAT2
, EWS/FLI1 activated transcript 2