Browse our SH2D1B Proteins (SH2D1B)

Full name:
SH2 Domain Containing 1B Proteins (SH2D1B)
On www.antibodies-online.com are 5 SH2 Domain Containing 1B (SH2D1B) Proteins from 3 different suppliers available. Additionally we are shipping SH2D1B Antibodies (58) and many more products for this protein. A total of 67 SH2D1B products are currently listed.
Synonyms:
EAT-2, EAT-2A, Eat2, Eat2a, RGD1563935, Sh2d1b, Sh2d1b1
list all proteins Gene Name GeneID UniProt
Rat SH2D1B SH2D1B 501869  
SH2D1B 117157 O14796
SH2D1B 26904  

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SH2D1B Proteins (SH2D1B) by Origin

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Human SH2 Domain Containing 1B (SH2D1B) interaction partners

  1. When compared with SAP (show APCS Proteins), the other single SH2 domain protein in human, EAT2 shows similar binding energies to unphosphorylated ligands. This is inconsistent to the previous data showing low affinity of EAT2 toward unphosphorylated peptides compared to SAP (show APCS Proteins) which shows high affinity

  2. Data indicate that Ewing's sarcoma-associated transcript-2 (EAT-2) over-expression increased the anti-tumor activity of NK cells against K562 tumor cell. targets.

  3. EAT-2 mediates its effects in natural killer cells by linking SLAM (show SLAMF1 Proteins) family receptors to phospholipase Cgamma, calcium fluxes, and Erk (show EPHB2 Proteins) kinase.

  4. NTB-A-mediated IFN-gamma production was greatly reduced in the absence of SLAM-associated protein (SAP), demonstrating that cytokine production and cytotoxicity are differentially dependent on SAP and possibly EAT-2

Mouse (Murine) SH2 Domain Containing 1B (SH2D1B) interaction partners

  1. EAT-2 negatively regulates cytokine production in dendritic cells downstream of SLAM (show SLAMF1 Proteins) engagement and a genetic polymorphism that disturbs this process promotes the development of lupus.

  2. EAT-2 mediates its effects in natural killer cells by linking SLAM (show SLAMF1 Proteins) family receptors to phospholipase Cgamma, calcium fluxes, and Erk (show EPHB2 Proteins) kinase.

  3. EAT-2A and EAT-2B act as positive regulators of signaling lymphocyte activation molecule (show SLAMF1 Proteins) family receptor-specific NK cell functions in C57BL/6 mice.

  4. Taken together, the data suggest that both EAT-2A and EAT-2B are adapters that recruit Src (show SRC Proteins) kinases to SLAM (show SLAMF1 Proteins) family receptors using a mechanism that is distinct from that of SAP (show APCS Proteins).

  5. EAT-2 mediates CRACC (show SLAMF7 Proteins) function. In the absence of EAT-2, CRACC (show SLAMF7 Proteins) inhibited natural killer cell function.

SH2D1B Protein Profile

Protein Summary

By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001

Alternative names and synonyms associated with SH2D1B

  • SH2 domain containing 1B (Sh2d1b)
  • SH2 domain containing 1B (SH2D1B)
  • SH2 domain protein 1B1 (Sh2d1b1)
  • EAT-2 protein
  • EAT-2A protein
  • Eat2 protein
  • Eat2a protein
  • RGD1563935 protein
  • Sh2d1b protein
  • Sh2d1b1 protein

Protein level used designations for SH2D1B

SH2 domain protein 1B1 , SH2 domain containing 1B , SH2 domain-containing protein 1B , EAT-2 , EWS/FLI1-activated transcript 2 , SH2 domain-containing molecule EAT2 , EWS/FLI1 activated transcript 2

GENE ID SPECIES
501869 Rattus norvegicus
418411 Gallus gallus
457464 Pan troglodytes
609474 Canis lupus familiaris
617485 Bos taurus
720097 Macaca mulatta
117157 Homo sapiens
26904 Mus musculus
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