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anti-Human FLT4 antibody for Intracellular Flow Cytometry

Recommended FLT4 Antibody (supplied by: Log in to see )

Antigen
Fms-Related Tyrosine Kinase 4 (FLT4) Antibodies
  • 6130401C07
  • AI323512
  • cb1059
  • Chy
  • Flk-1
  • Flk1
  • Flt-4
  • FLT41
  • Krd-1
  • LMPH1A
  • Ly73
  • PCL
  • sVEGFR-2
  • VEGFR-2
  • VEGFR-3
  • VEGFR2
  • Vegfr3
  • VEGFR3
Reactivity
Human
158
76
31
2
1
Host
Mouse
120
60
17
4
1
Clonality
Monoclonal
Conjugate
This FLT4 antibody is conjugated to APC
13
7
6
5
4
2
2
2
2
2
2
2
2
2
2
Application
Flow Cytometry (FACS), Intracellular Flow Cytometry (ICFC)
114
83
55
31
26
22
20
12
10
9
4
3
3
1
1
Supplier
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Catalog No. ABIN2658417
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008704084 ABIN2658418 FACS ICFC APC Mouse IgG1 kappa Log in to see 9D9F9 7

Top referenced anti-FLT4 antibody for Intracellular Flow Cytometry

Similar anti-FLT4 Antibodies

Application / Reactivity Human
ELISA 69 Antibodies
ELISA (Capture) 1 Antibodies
Enzyme Immunoassay (EIA) 9 Antibodies
Flow Cytometry (FACS) 11 Antibodies
Immunochromatography (IC) 1 Antibodies
Immunocytochemistry (ICC) 3 Antibodies
Immunofluorescence (IF) 11 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 22 Antibodies
Immunohistochemistry (IHC) 50 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 5 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 27 Antibodies
Immunoprecipitation (IP) 19 Antibodies
Intracellular Flow Cytometry (ICFC) 2 Antibodies
Western Blotting (WB) 100 Antibodies

General

Antigen Fms-Related Tyrosine Kinase 4 (FLT4) Antibodies
Reactivity Human
(158), (76), (31), (2), (1)
Host Mouse
(120), (60), (17), (4), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This FLT4 antibody is conjugated to APC
(13), (7), (6), (5), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Flow Cytometry (FACS), Intracellular Flow Cytometry (ICFC)
(114), (83), (55), (31), (26), (22), (20), (12), (10), (9), (4), (3), (3), (1), (1)
Pubmed 7 references available
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Product Details anti-FLT4 Antibody

Target Details FLT4 Application Details Handling References for anti-FLT4 Antibody (ABIN2658417) Images
Purification The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
Clone 9D9F9
Isotype IgG1 kappa

Target Details FLT4

Product Details anti-FLT4 Antibody Application Details Handling References for anti-FLT4 Antibody (ABIN2658417) Images back to top
Antigen
Alternative Name VEGFR-3 (FLT4 Antibody Abstract)
Background Receptor tyrosine Kinase VEGFR-3, also known as FLT4, together with VEGFR1 (FIT1) and VEGFR2 (KDR/Flk-1), are the receptors for vascular endothelial growth factors (VEGF). The VEGFR family belongs to the class II subfamily of receptor tyrosine kinases (RTKs), containing a large extracellular region which is composed of seven Ig-like domains (D1-D7), a single transmembrane, helix, and a cytoplasmic region with tyrosine kinase activity. In VEGFR-3, the fifth Ig homology domain is proteolytically cleaved which results in polypeptides that remain linked by two disulfide bonds. VEGFR-3 is widely expressed on all endothelial cells in early embryogenesis, while, in adult tissues, VEGFR-3 expression disappears from the vascular endothelial cells and is observed only on the lymphatic endothelium. VEGF-C and VEGF-D activation of VEGFR-3 plays an important role in the formation of the lymphatic vessel system. Aberrant activation or expression of VEGFR and their ligands has been implicated in tumor angiogenesis, coronary artery disease, diabetic blindness, and other diseases.
Pathways RTK Signaling

Application Details

Product Details anti-FLT4 Antibody Target Details FLT4 Handling References for anti-FLT4 Antibody (ABIN2658417) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-FLT4 Antibody Target Details FLT4 Application Details References for anti-FLT4 Antibody (ABIN2658417) Images back to top
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-FLT4 Antibody (ABIN2658417)

Product Details anti-FLT4 Antibody Target Details FLT4 Application Details Handling Images back to top
Background publications

Tammela, Zarkada, Wallgard, Murtomäki, Suchting, Wirzenius, Waltari, Hellström, Schomber, Peltonen, Freitas, Duarte, Isoniemi, Laakkonen, Christofori, Ylä-Herttuala, Shibuya, Pytowski, Eichmann et al.: "Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. ..." in: Nature, Vol. 454, Issue 7204, pp. 656-60, 2008

Kilic, Oliveira-Ferrer, Neshat-Vahid, Irmak, Obst-Pernberg, Wurmbach, Loges, Kilic, Weil, Lauke, Tilki, Singer, Ergün: "Lymphatic reprogramming of microvascular endothelial cells by CEA-related cell adhesion molecule-1 via interaction with VEGFR-3 and Prox1." in: Blood, Vol. 110, Issue 13, pp. 4223-33, 2007

Partanen, Arola, Saaristo, Jussila, Ora, Miettinen, Stacker, Achen, Alitalo: "VEGF-C and VEGF-D expression in neuroendocrine cells and their receptor, VEGFR-3, in fenestrated blood vessels in human tissues." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 14, Issue 13, pp. 2087-96, 2000

Folpe, Veikkola, Valtola, Weiss et al.: "Vascular endothelial growth factor receptor-3 (VEGFR-3): a marker of vascular tumors with presumed lymphatic differentiation, including Kaposi's sarcoma, kaposiform and Dabska-type ..." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 13, Issue 2, pp. 180-5, 2000

Valtola, Salven, Heikkilä, Taipale, Joensuu, Rehn, Pihlajaniemi, Weich, deWaal, Alitalo: "VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer." in: The American journal of pathology, Vol. 154, Issue 5, pp. 1381-90, 1999

Jussila, Valtola, Partanen, Salven, Heikkilä, Matikainen, Renkonen, Kaipainen, Detmar, Tschachler, Alitalo, Alitalo: "Lymphatic endothelium and Kaposi's sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3." in: Cancer research, Vol. 58, Issue 8, pp. 1599-604, 1998

Galland, Karamysheva, Mattei, Rosnet, Marchetto, Birnbaum: "Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene." in: Genomics, Vol. 13, Issue 2, pp. 475-8, 1992

Images

Product Details anti-FLT4 Antibody Target Details FLT4 Application Details Handling References for anti-FLT4 Antibody (ABIN2658417) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-FLT4 antibody (Fms-Related Tyrosine Kinase 4)  (APC) (ABIN2658417) anti-Fms-Related Tyrosine Kinase 4 (FLT4) antibody (APC)