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anti-Mouse (Murine) GRB2 antibody for Enzyme Immunoassay

Recommended GRB2 Antibody (supplied by: Log in to see )

Antigen
Growth Factor Receptor-Bound Protein 2 (GRB2) Antibodies
  • AA408164
  • ASH
  • Ash
  • EGFRBP-GRB2
  • GRB2
  • grb2
  • Grb3-3
  • MST084
  • MSTP084
  • NCKAP2
  • wu:fb18e12
  • wu:fb34e06
  • zgc:73077
Epitope
C-Term
34
18
15
7
6
6
6
3
3
3
3
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
148
41
41
9
7
3
3
2
2
2
2
1
1
Host
Goat
99
29
21
2
Clonality
Polyclonal
Conjugate
This GRB2 antibody is un-conjugated
5
4
3
3
3
3
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
129
65
53
29
9
8
4
3
3
2
1
Supplier
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Catalog No. ABIN782889
$ 203.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008871704 ABIN374150 EIA IHC (p) WB Goat C-Term Log in to see Polyclonal 1

Top referenced anti-GRB2 antibody for Enzyme Immunoassay

Similar anti-GRB2 Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Rattus) Cow (Bovine) Dog (Canine)
Western Blotting (WB) 129 Antibodies 41 Antibodies 40 Antibodies 9 Antibodies 7 Antibodies
Immunoprecipitation (IP) 9 Antibodies 3 Antibodies 3 Antibodies 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 32 Antibodies 6 Antibodies 9 Antibodies 9 Antibodies 3 Antibodies
Immunohistochemistry (IHC) 56 Antibodies 15 Antibodies 13 Antibodies 3 Antibodies 4 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 3 Antibodies

General

Antigen Growth Factor Receptor-Bound Protein 2 (GRB2) Antibodies
Epitope C-Term
(34), (18), (15), (7), (6), (6), (6), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(148), (41), (41), (9), (7), (3), (3), (2), (2), (2), (2), (1), (1)
Host Goat
(99), (29), (21), (2)
Clonality
Polyclonal
Conjugate This GRB2 antibody is un-conjugated
(5), (4), (3), (3), (3), (3)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(129), (65), (53), (29), (9), (8), (4), (3), (3), (2), (1)
Pubmed 1 reference available
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Product Details anti-GRB2 Antibody

Target Details GRB2 Application Details Handling References for anti-GRB2 Antibody (ABIN782889) Images
Sequence C-PRNYVTPVNR NV
Specificity This antibody detects GRB2 / ASH at C-term.
Cross-Reactivity (Details) Species reactivity (expected):Rat, Canine (Dog), Cow.
Species reactivity (tested):Human, Mouse
Purification Immunoaffinity Chromatography
Immunogen Synthetic peptide from C-Terminus of the protein sequence according to NP_002077.1, NP_987102.1 Genename: GRB2

Target Details GRB2

Product Details anti-GRB2 Antibody Application Details Handling References for anti-GRB2 Antibody (ABIN782889) Images back to top
Antigen
Alternative Name GRB2 / ASH (GRB2 Antibody Abstract)
Background Growth factor receptor bound protein 2 (GRB2), also known as Ash protein, is a 24 kDa protein that contains a central Src homology (SH2) domain flanked by two SH3 domains. GRB2 is believed to be a regulatory subunit of signaling molecules whose activity is modulated by receptor binding. GRB2 associates with activated (tyrosine phosphorylated) EGFR and PDGFR via its SH2 domain as well as IRS1, SHC, and LNK through SH2 and SH3 domains. The SH3 domain binds to SOS, a guanine nucleotide exchange factor for Ras proteins. Endocytosis of activated EGFR requires the interaction of GRB2 with the GTP binding protein dynamin, a factor essential to the formation of endocytotic vesicle. It is ubiquitously expressed and several isoforms are produced by alternative splicing. On SDS PAGE, GRB2 has an apparent molecular weight of 28 kDa.Synonyms: Growth factor receptor-bound protein 2
Gene ID 2885
NCBI Accession NP_002077
UniProt P62993
Research Area Signaling
Pathways RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-GRB2 Antibody Target Details GRB2 Handling References for anti-GRB2 Antibody (ABIN782889) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-GRB2 Antibody Target Details GRB2 Application Details References for anti-GRB2 Antibody (ABIN782889) Images back to top
Concentration 0.5 mg/mL
Buffer Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-GRB2 Antibody (ABIN782889)

Product Details anti-GRB2 Antibody Target Details GRB2 Application Details Handling Images back to top
Background publications

Lowenstein, Daly, Batzer, Li, Margolis, Lammers, Ullrich, Skolnik, Bar-Sagi, Schlessinger: "The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling." in: Cell, Vol. 70, Issue 3, pp. 431-42, 1992

Images

Product Details anti-GRB2 Antibody Target Details GRB2 Application Details Handling References for anti-GRB2 Antibody (ABIN782889) back to top
Supplier Images
 image for anti-GRB2 antibody (Growth Factor Receptor-Bound Protein 2) (C-Term) (ABIN782889) anti-Growth Factor Receptor-Bound Protein 2 (GRB2) (C-Term) antibody
 image for anti-GRB2 antibody (Growth Factor Receptor-Bound Protein 2) (C-Term) (ABIN782889) anti-Growth Factor Receptor-Bound Protein 2 (GRB2) (C-Term) antibody (Image 2)