Growth factor receptor bound protein 2 (GRB2), also known as Ash protein, is a 24 kDaprotein that contains a central Src homology (SH2) domain flanked by two SH3domains. GRB2 is believed to be a regulatory subunit of signaling molecules whoseactivity is modulated by receptor binding. GRB2 associates with activated (tyrosinephosphorylated) EGFR and PDGFR via its SH2 domain as well as IRS1, SHC, and LNKthrough SH2 and SH3 domains. The SH3 domain binds to SOS, a guanine nucleotideexchange factor for Ras proteins. Endocytosis of activated EGFR requires theinteraction of GRB2 with the GTP binding protein dynamin, a factor essential to theformation of endocytotic vesicle. It is ubiquitously expressed and several isoforms areproduced by alternative splicing. On SDS PAGE, GRB2 has an apparent molecularweight of 28 kDa. Alternate Names: anti-Abundant SRC homology antibody, anti-Ash protein antibody, anti-Epidermalgrowth factor receptor binding protein antibody, anti-GRB2 adapter protein antibody,anti-Growth Factor Receptor Bound Protein 2 antibody, anti-Growth factor receptorbound protein 3 antibody, anti-HT027 antibody, anti-SEM5 antibody, anti-SH2/SH3adapter GRB2 antibody. Gene Symbol: GRB2
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