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anti-Xenopus laevis GRB2 antibody for Immunohistochemistry

Recommended GRB2 Antibody (supplied by: Log in to see )

Antigen
Growth Factor Receptor-Bound Protein 2 (GRB2) Antibodies
  • AA408164
  • ASH
  • Ash
  • EGFRBP-GRB2
  • GRB2
  • grb2
  • Grb3-3
  • MST084
  • MSTP084
  • NCKAP2
  • wu:fb18e12
  • wu:fb34e06
  • zgc:73077
Reactivity
Cow (Bovine), Human, Mouse (Murine), Rat (Rattus), Xenopus laevis
152
45
45
10
8
3
3
2
2
2
2
1
1
Host
Mouse
102
29
22
2
Clonality
Monoclonal
Conjugate
This GRB2 antibody is un-conjugated
5
4
3
3
3
3
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (IHC)
133
67
53
30
9
8
5
3
3
2
1
Supplier
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Available images

Catalog No. ABIN267213
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Similar anti-GRB2 Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Rattus) Cow (Bovine) Xenopus laevis
Western Blotting (WB) 132 Antibodies 44 Antibodies 43 Antibodies 9 Antibodies
Immunoprecipitation (IP) 9 Antibodies 3 Antibodies 3 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 32 Antibodies 6 Antibodies 9 Antibodies 9 Antibodies 2 Antibodies
Immunohistochemistry (IHC) 56 Antibodies 15 Antibodies 13 Antibodies 3 Antibodies 1 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 3 Antibodies

General

Antigen Growth Factor Receptor-Bound Protein 2 (GRB2) Antibodies
Reactivity Cow (Bovine), Human, Mouse (Murine), Rat (Rattus), Xenopus laevis
(152), (45), (45), (10), (8), (3), (3), (2), (2), (2), (2), (1), (1)
Host Mouse
(102), (29), (22), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This GRB2 antibody is un-conjugated
(5), (4), (3), (3), (3), (3)
Application Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (IHC)
(133), (67), (53), (30), (9), (8), (5), (3), (3), (2), (1)
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Product Details anti-GRB2 Antibody

Target Details GRB2 Application Details Handling Images
Cross-Reactivity Human, Rat (Rattus), Mouse (Murine), Cow (Bovine), Xenopus laevis
Purification Protein G purified
Immunogen Purified recombinant human Grb2 protein.
Clone 2GB04
Isotype IgG1 kappa

Target Details GRB2

Product Details anti-GRB2 Antibody Application Details Handling Images back to top
Antigen
Alternative Name GRB2 / ASH (GRB2 Antibody Abstract)
Background Growth factor receptor bound protein 2 (GRB2), also known as Ash protein, is a 24 kDaprotein that contains a central Src homology (SH2) domain flanked by two SH3domains. GRB2 is believed to be a regulatory subunit of signaling molecules whoseactivity is modulated by receptor binding. GRB2 associates with activated (tyrosinephosphorylated) EGFR and PDGFR via its SH2 domain as well as IRS1, SHC, and LNKthrough SH2 and SH3 domains. The SH3 domain binds to SOS, a guanine nucleotideexchange factor for Ras proteins. Endocytosis of activated EGFR requires theinteraction of GRB2 with the GTP binding protein dynamin, a factor essential to theformation of endocytotic vesicle. It is ubiquitously expressed and several isoforms areproduced by alternative splicing. On SDS PAGE, GRB2 has an apparent molecularweight of 28 kDa. Alternate Names: anti-Abundant SRC homology antibody, anti-Ash protein antibody, anti-Epidermalgrowth factor receptor binding protein antibody, anti-GRB2 adapter protein antibody,anti-Growth Factor Receptor Bound Protein 2 antibody, anti-Growth factor receptorbound protein 3 antibody, anti-HT027 antibody, anti-SEM5 antibody, anti-SH2/SH3adapter GRB2 antibody.
Gene Symbol: GRB2
Gene ID 2885, 14784, 81504
Research Area Signaling
Pathways RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-GRB2 Antibody Target Details GRB2 Handling Images back to top
Application Notes Recommended dilutions: Immunohistochemistry-Paraffin 1-2 µg/mL, Immunocytochemistry/Immunofluorescence 1:10-1:500, Immunohistochemistry 1:10-1:500
Restrictions For Research Use only

Handling

Product Details anti-GRB2 Antibody Target Details GRB2 Application Details Images back to top
Format Liquid
Buffer 10 mM PBS, pH 7.4, with 0.2 % BSA, Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Do not freeze.
Storage 4 °C

Images

Product Details anti-GRB2 Antibody Target Details GRB2 Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-GRB2 antibody (Growth Factor Receptor-Bound Protein 2) (ABIN267213) Formalin-fixed, paraffin-embedded human tonsil stained with Grb2 using peroxidase-con...