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anti-Human HBEGF Antibodies:
anti-Rat (Rattus) HBEGF Antibodies:
anti-Mouse (Murine) HBEGF Antibodies:
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Human Monoclonal HBEGF Primary Antibody for ICC, IF - ABIN2451994
Prenzel, Zwick, Daub, Leserer, Abraham, Wallasch, Ullrich: EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. in Nature 2000
Show all 4 Pubmed References
Human Monoclonal HBEGF Primary Antibody for ICC, IF - ABIN3201018
Miyamoto, Hirata, Yamazaki, Kageyama, Hasuwa, Mizushima, Tanaka, Yagi, Sonoda, Kai, Kanoh, Nakano, Mekada: Heparin-binding EGF-like growth factor is a promising target for ovarian cancer therapy. in Cancer research 2004
Show all 4 Pubmed References
Human Monoclonal HBEGF Primary Antibody for FACS - ABIN4897711
Mandl, Drechsler, Jansen, Neideck, Noels, Faussner, Soehnlein, Weber, Döring: Evaluation of the BDCA2-DTR Transgenic Mouse Model in Chronic and Acute Inflammation. in PLoS ONE 2015
Human Polyclonal HBEGF Primary Antibody for IF (p), IHC (p) - ABIN701050
Lebkuechner, Wilhelmsson, Möllerström, Pekna, Pekny: Heterogeneity of Notch signaling in astrocytes and the effects of GFAP and vimentin deficiency. in Journal of neurochemistry 2015
These results suggest that there is an EGF (show EGF Antibodies) signaling network in the zebrafish ovarian follicle, and the functionality of this network is self-regulated by its own members.
Heparan sulfate proteoglycans and heparin derivatives further enhance HBEGF-induced differentiation by forming a complex with the epidermal growth factor receptor (show EGFR Antibodies)
this study suggests that HBEGF promotes the formation of gliomas, is necessary for tumor maintenance and therefore may be a novel therapeutic target.
Results show that HBEGF is highly expressed in primary ovarian tumors and increases as the disease progresses.
Serous carcinomatous component championed by expression of HB-EGF predisposes to recurrence/metastasis in stage I metastasis and recurrence in stage I uterine malignant mixed mullerian tumor.
Annexin A2 (show ANXA2 Antibodies) and HB-EGF are overexpressed and are being secreted into serum in Her-2 (show ERBB2 Antibodies) negative breast cancer patients.
Study demonstrates that HBEGF is post-transcriptionally regulated by low O2 (placental environment) through a mechanism involving interactions of miRNAs with its 3'UTR (show UTS2R Antibodies).
MMP14 (show MMP14 Antibodies) plays an important mechanistic role in NSCLC progression, by supporting cancer invasiveness, promoting collagen degradation, and releasing HB-EGF, which accelerates lung tumor progression.
These results indicate that this new anti-HB-EGF mAb 2-108 would be useful in the diagnosis of HB-EGF-related cancers and would be a strong tool in both basic and clinical research on HB-EGF.
This antibody reacts with human HB-EGF but not mouse HB-EGF. No cross-reactivity to other EGFR (show EGFR Antibodies) ligands was observed by antigen ELISA.
HB-EGF is a molecular target for the resistance of ovarian cancer to paclitaxel and CRM197 as a HB-EGF-targeted agent might be a chemosensitizing agent for paclitaxel-resistant ovarian carcinoma
HB-EGF stimulates Prss56 (show PRSS56 Antibodies) expression via EGFR (show EGFR Antibodies)-ERK (show EPHB2 Antibodies) pathway.
HB-EGF Tg mice were shown to develop more severe liver fibrosis when treated with carbon tetrachloride or bile duct ligation, with increased matrix metalloproteinases 13 activity and enhanced expression of fibrogenic genes including alpha-smooth muscle actin (show ACTG2 Antibodies) and collagen I.
These results indicate that ATX (show ENPP2 Antibodies)-lysophosphatidic acid-LPA3 (show LPAR3 Antibodies) signaling at the embryo-epithelial boundary induces decidualization via the canonical HB-EGF and COX-2 (show COX2 Antibodies) pathways.
our results suggest that shedding of HB-EGF from endothelium plays an important role in Ang II (show AGT Antibodies)-induced renal injury by linking Ang II (show AGT Antibodies)-AT1R (show AGTRAP Antibodies) with EGFR (show EGFR Antibodies) transactivation.
Results suggest that HB-EGF secreted from KRas-mutated colorectal cancer cells promotes intestinal myofibroblasts migration through ERK (show EPHB2 Antibodies) and JNK (show MAPK8 Antibodies) activation, which, in turn, could support cancer progression.
this study revealed that HB-EGF as well as HGF (show HGF Antibodies) inhibited BDL-induced cholestatic liver injury by predominantly exerting acute cytoprotective and chronic antifibrotic effects, respectively.
Abnormal keratinocyte migration and down-regulated expression of the Hbegf gene might be associated with impaired eyelid development in B6-Co mice.
Pelvic irradiation increases versican (show Vcan Antibodies) expression in bladder and rectum.
Psychiatric, social-behavioral and cognitive abnormalities were also observed in hippocampal Hbegf knockout mice.
HB-EGF promotes enteric neural stem cell proliferation and migration in a mouse model
These results indicate that HB-EGF and its receptors expression changed in bovine endometrium throughout the oestrous cycle; IFN-tau increased their expression in cultured endometrial cells.
Heparin-binding EGF-like growth factor is main component in chromaffin granules responsible for neurotrophic effect on dopaminergic neurones. Protective effects on nigrostriatal dopaminergic neurones. Candidate for treatment of Parkinson's disease.
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
proheparin-binding EGF-like growth factor
, heparin-binding EGF-like growth factor
, Heparin-binding EGF-like growth factor
, diphtheria toxin receptor (heparin-binding EGF-like growth factor)
, diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor)
, heparin-binding epidermal growth factor
, Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor)
, heparin binding epidermal growth factor-like growth factor
, heparin-binding epidermal -growth - like growth factor
, heparin-binding epidermal -growth factor
, diphtheria toxin receptor
, heparin-binding epidermal growth factor-like growth factor