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|Antigen||C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This MERTK antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
|3 references available|
|Supplier||Log in to see|
Product Details anti-MERTK AntibodyTarget Details MERTK Application Details Handling References for anti-MERTK antibody (ABIN359900) Images
|Specificity||This antibody reacts to MERTK.|
|Purification||Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MERK.|
Target Details MERTKProduct Details anti-MERTK Antibody Application Details Handling References for anti-MERTK antibody (ABIN359900) Images back to top
|Alternative Name||MERTK (MERTK Antibody Abstract)|
|Background||Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.Synonyms: C-mer, MER, Proto-oncogene tyrosine-protein kinase MER, Receptor tyrosine kinase MerTK|
|Gene ID||10461, 9606|
|Research Area||Neurology, Tyrosine Kinases|
Application DetailsProduct Details anti-MERTK Antibody Target Details MERTK Handling References for anti-MERTK antibody (ABIN359900) Images back to top
ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/10 - 1/50. Flow cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-MERTK Antibody Target Details MERTK Application Details References for anti-MERTK antibody (ABIN359900) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-MERTK antibody (ABIN359900)Product Details anti-MERTK Antibody Target Details MERTK Application Details Handling Images back to top
Thompson, McHenry, Li, Richards, Othman, Schwinger, Vollrath, Jacobson, Gal: "Retinal dystrophy due to paternal isodisomy for chromosome 1 or chromosome 2, with homoallelism for mutations in RPE65 or MERTK, respectively." in: American journal of human genetics, Vol. 70, Issue 1, pp. 224-9, 2001
Weier, Fung, Lersch: "Assignment of protooncogene MERTK (a.k.a. c-mer) to human chromosome 2q14.1 by in situ hybridization." in: Cytogenetics and cell genetics, Vol. 84, Issue 1-2, pp. 91-2, 1999
Graham, Dawson, Mullaney, Snodgrass, Earp: "Cloning and mRNA expression analysis of a novel human protooncogene, c-mer." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 5, Issue 6, pp. 647-57, 1994
ImagesProduct Details anti-MERTK Antibody Target Details MERTK Application Details Handling References for anti-MERTK antibody (ABIN359900) back to top