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anti-Rat (Rattus) MERTK antibody for Immunoprecipitation

Recommended MERTK Antibody (supplied by: Log in to see )

Antigen
C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) Antibodies
  • C-EYK
  • c-mer
  • DKFZp469D2215
  • Eyk
  • Mer
  • MER
  • MERTK
  • nmf12
  • Nyk
  • rdy
  • RP38
  • si:ch1073-268l12.2
Epitope
N-Term
36
34
13
5
4
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Monkey, Mouse (Murine), Rat (Rattus)
158
43
31
3
1
1
Host
Rabbit
108
27
26
4
Clonality
Polyclonal
Conjugate
This MERTK antibody is un-conjugated
11
8
7
7
6
6
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB)
107
95
53
14
14
13
11
10
9
8
2
2
Supplier
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Catalog No. ABIN493123
$ 456.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008946119 ABIN2712097 IHC (fro) IP WB Rabbit C-Term Log in to see Polyclonal 2
0.0008946119 ABIN1584125 IP IHC ELISA WB Rabbit C-Term Log in to see Polyclonal
0.0008946119 ABIN2750538 CM ICC IF IP IHC ELISA WB FITC Rabbit IgG Middle Region Log in to see Polyclonal
0.0008946119 ABIN2750539 CM ICC IF IP IHC ELISA WB FITC Rabbit IgG C-Term Log in to see Polyclonal
0.0008946119 ABIN2750537 CM ICC IF IP IHC ELISA WB FITC Rabbit IgG N-Term Log in to see Polyclonal
0.0008946119 ABIN2746860 CM ICC IF IP IHC ELISA WB Rabbit IgG N-Term Log in to see Polyclonal
0.0008946119 ABIN2750535 CM ICC IF IP IHC ELISA WB Rabbit IgG Middle Region Log in to see Polyclonal
0.0008946119 ABIN2750536 CM ICC IF IP IHC ELISA WB Rabbit IgG C-Term Log in to see Polyclonal

Top referenced anti-MERTK antibody for Immunoprecipitation

Similar anti-MERTK Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Rattus) Monkey
Western Blotting (WB) 107 Antibodies 30 Antibodies 20 Antibodies 4 Antibodies
Neutralization (Neut) 1 Antibodies
Immunoprecipitation (IP) 11 Antibodies 1 Antibodies 9 Antibodies 9 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 14 Antibodies 5 Antibodies 3 Antibodies
Immunohistochemistry (IHC) 53 Antibodies 17 Antibodies 11 Antibodies 2 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 3 Antibodies 1 Antibodies 2 Antibodies 2 Antibodies

General

Antigen C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) Antibodies
Epitope N-Term
(36), (34), (13), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Monkey, Mouse (Murine), Rat (Rattus)
(158), (43), (31), (3), (1), (1)
Host Rabbit
(108), (27), (26), (4)
Clonality
Polyclonal
Conjugate This MERTK antibody is un-conjugated
(11), (8), (7), (7), (6), (6), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB)
(107), (95), (53), (14), (14), (13), (11), (10), (9), (8), (2), (2)
Pubmed 2 references available
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Product Details anti-MERTK Antibody

Target Details MERTK Application Details Handling References for anti-MERTK Antibody (ABIN493123) Images
Sequence EEE IKP DQP FSG PLP GS{C}
Specificity This antibody detects a single 170-175 kDa MERTK protein in human RPE cell extracts. The antibody also reacts to a 90 kDa protein in rat testis extracts.
Cross-Reactivity (Details) Species reactivity (tested):Human, monkey, mouse, rat
Purification Affinity chromatography
Immunogen Synthetic peptide corresponding to N-term of MERTK

Target Details MERTK

Product Details anti-MERTK Antibody Application Details Handling References for anti-MERTK Antibody (ABIN493123) Images back to top
Antigen
Alternative Name MERTK (MERTK Antibody Abstract)
Background In vertebrate, the photoreceptor cells are the basic sensory apparatus of the retina primarily converting photon energy absorbed from light into neuronal signals. The photoreceptor proximal outer segments are synthesized daily by cell bodies, and outer segment tips are removed with a circadian rhythm. The shed outer segments are endocytosed by adjacent retinal pigment epithelial (RPE) cells, and are recycled to photoreceptors (1). Mutation of a receptor tyrosine kinase gene, Mertk, in the Royal College of Surgeons (RCS) rat results in defective phagocytosis of photoreceptor outer segments by the retinal pigment epithelium (RPE) and retinal degeneration (2) resulting in to retinitis pigmentosa. The receptor tyrosine kinase MERTK protein is a approximately 170-175 kDa (994 amino acids) protein expressed in long evans rat testis and RPEs. The MERTK protein has a tyrosine kinase domain closer to the C-terminal region and putative phosphorylation sites.Synonyms: C-mer, MER, Proto-oncogene tyrosine-protein kinase MER, Receptor tyrosine kinase MerTK
Gene ID 10461
NCBI Accession NP_006334
UniProt Q12866
Research Area Neurology, Tyrosine Kinases
Pathways RTK Signaling

Application Details

Product Details anti-MERTK Antibody Target Details MERTK Handling References for anti-MERTK Antibody (ABIN493123) Images back to top
Application Notes Immunohistochemistry on frozen sections. Immunoprecipitaion and i. p pull-down assays: > 1: 200 (1 μL/250 μg protein extracts). Western blot: 1: 500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-MERTK Antibody Target Details MERTK Application Details References for anti-MERTK Antibody (ABIN493123) Images back to top
Concentration 0.65 - 1.25 mg/mL
Buffer Stabilization buffer with 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.

References for anti-MERTK Antibody (ABIN493123)

Product Details anti-MERTK Antibody Target Details MERTK Application Details Handling Images back to top
Background publications

DCruz, Yasumura, Weir, Matthes, Abderrahim, LaVail, Vollrath: "Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat." in: Human molecular genetics, Vol. 9, Issue 4, pp. 645-51, 2000

Gal, Li, Thompson, Weir, Orth, Jacobson, Apfelstedt-Sylla, Vollrath: "Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa." in: Nature genetics, Vol. 26, Issue 3, pp. 270-1, 2000