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|Antigen||Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) Antibodies|
|Conjugate||This MUSK antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|1 reference available|
|Supplier||Log in to see|
Product Details anti-MUSK AntibodyTarget Details MUSK Application Details Handling References for anti-MUSK antibody (ABIN359903) Images
|Specificity||This antibody reacts to MUSK.|
|Purification||Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human MUSK.|
Target Details MUSKProduct Details anti-MUSK Antibody Application Details Handling References for anti-MUSK antibody (ABIN359903) Images back to top
|Alternative Name||MUSK (MUSK Antibody Abstract)|
|Background||Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).Synonyms: Muscle, Muscle-specific kinase receptor, skeletal receptor tyrosine-protein kinase|
|Gene ID||4593, 9606|
|Research Area||Extracellular Matrix, Tyrosine Kinases, Kinases/Phosphatases|
|Pathways||RTK Signaling, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development|
Application DetailsProduct Details anti-MUSK Antibody Target Details MUSK Handling References for anti-MUSK antibody (ABIN359903) Images back to top
ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-MUSK Antibody Target Details MUSK Application Details References for anti-MUSK antibody (ABIN359903) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-MUSK antibody (ABIN359903)Product Details anti-MUSK Antibody Target Details MUSK Application Details Handling Images back to top
Cantrell: "Phosphoinositide 3-kinase signalling pathways." in: Journal of cell science, Vol. 114, Issue Pt 8, pp. 1439-45, 2001
ImagesProduct Details anti-MUSK Antibody Target Details MUSK Application Details Handling References for anti-MUSK antibody (ABIN359903) back to top