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anti-Rat (Rattus) Neuregulin 4 Antibodies:
anti-Human Neuregulin 4 Antibodies:
anti-Mouse (Murine) Neuregulin 4 Antibodies:
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NRG4 and its receptor ErbB4 (show ERBB4 Antibodies) are present in human breast milk and developing human intestine, respectively. Thus, NRG4-ErbB4 (show ERBB4 Antibodies) signaling may be a novel pathway for therapeutic intervention or prevention in NEC.
Nrg4 might have a protective role in the development of Non-alcoholic fatty liver disease (NAFLD (show TSC2 Antibodies)).
results establish Nrg4 as a brown fat-enriched endocrine factor with therapeutic potential for the treatment of obesity-associated disorders, including type 2 diabetes and nonalcoholic fatty liver disease (NAFLD (show TSC2 Antibodies)).
Pharmacological inhibition of PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling reversed the anti-apoptotic effects of NRG4, confirming the role of this cascade in NRG4-induced cell survival
The recombinant neuregulin 4 induced the tyrosine phosphorylation of HER4 (show ERBB4 Antibodies).
NRG4 overexpression is associated with advanced-stage prostate cancer
describes a novel splice variant of the NRG4 gene, NRG4A2, which encodes a C-terminal region containing a predicted type I PDZ (show INADL Antibodies)-binding peptide (show HP Antibodies)
NRG4 was positive in almost all breast cancers studied.
Neuregulin-4 expression is downregulated during urinary bladder cancer progression
Pharmacological inhibition of PI3K/Akt (show AKT1 Antibodies) signaling reversed the anti-apoptotic effects of NRG4, confirming the role of this cascade in NRG4-induced cell survival
The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR\; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999
, pro-neuregulin-4, membrane-bound isoform
, heregulin 4