anti-Rat (Rattus) ROR2 antibody for Immunohistochemistry

Recommended ROR2 Antibody (supplied by: Log in to see )

Antigen
Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) Antibodies
  • ROR2
  • bdb
  • bdb1
  • Xror2
  • ntrkr2
  • MGC97773
  • LOC100219935
  • BDB
  • BDB1
  • NTRKR2
  • Ntrkr2
  • mRor2
  • receptor tyrosine kinase-like orphan receptor 2
  • ROR2
  • ror2
  • LOC100219935
  • LOC100351121
  • Ror2
Epitope
AA 900-950
24
20
19
18
14
7
6
5
4
3
3
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
158
24
12
4
4
3
2
1
1
1
1
Host
Rabbit
98
60
1
Clonality
Polyclonal
Conjugate
This ROR2 antibody is un-conjugated
10
9
8
7
7
6
5
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
125
63
56
50
10
9
2
2
1
1
1
1
Supplier
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Catalog No. ABIN2747364
$ 485.57
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN1876821 IHC WB Rabbit IgG Log in to see Polyclonal
1 ABIN2881183 IHC WB Rabbit IgG Log in to see Polyclonal
1 ABIN2751315 ELISA IHC IP WB FITC Rabbit IgG AA 900-950 Log in to see Polyclonal
1 ABIN2976053 IHC WB Rabbit IgG Log in to see Polyclonal
1 ABIN5558394 ELISA IHC IP WB Biotin Rabbit Log in to see Polyclonal

General

Antigen Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) Antibodies
Epitope AA 900-950
(24), (20), (19), (18), (14), (7), (6), (5), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(158), (24), (12), (4), (4), (3), (2), (1), (1), (1), (1)
Host Rabbit
(98), (60), (1)
Clonality
Polyclonal
Conjugate This ROR2 antibody is un-conjugated
(10), (9), (8), (7), (7), (6), (5), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
(125), (63), (56), (50), (10), (9), (2), (2), (1), (1), (1), (1)
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Product Details anti-ROR2 Antibody

Target Details ROR2 Application Details Handling Images
Blocking Peptide Blocking peptide for this product available: ABIN2751316
Specificity The antibody labels a strong band of ROR2 at 113 kDa in ABIN1741697 samples and in other cancer cell lines.
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Cross-Reactivity (Details) Does not cross react to any other cellular protein.
Characteristics ROR2- selective antibodies were generated against a peptide taken the C-terminal region. The ROR2-selective antibodies are affinity purified on an immobilized antigen based affinity matrix, the isolated antibodies were then stabilized in antibody stabilization buffer for long-term storage. The anti- ROR1-selective antibodies are fully characterized for applications in western blotting and ELISA at the recommended dilutions. The supplier provides ROR2 Western blot positive control samples in ready-to-use SDS-PAGE sample buffer. Limited quantities of antigenic blocking peptide for ROR2 antibody is also available, please inquire before ordering.
Purification Affinity Purified
Immunogen Synthetic peptide taken within amino acid region 900-950 on human ROR2 protein.
Isotype IgG

Target Details ROR2

Product Details anti-ROR2 Antibody Application Details Handling Images back to top
Antigen
Alternative Name ROR2 (ROR2 Antibody Abstract)
Background The Receptor tyrosine kinase-like Orphan Receptor (ROR) proteins are conserved tyrosine kinase receptors that pattern tissues and organs during embryonic development and in adulthood. ROR family proteins are ligand-dependent transcription factors that are required for skeletal and neuronal development, and modulate cell migration, cell polarity, and convergent extension. RORs act as Wnt receptors signaling via novel non-canonical Wnt pathways mediated by the adapter protein disheveled and the non-receptor tyrosine kinase Src. RORs can either activate or repress Wnt target expression depending on the cellular context and can also modulate signal transduction by sequestering Wnt ligands away from their signaling receptors.The mammalian ROR family of receptor tyrosine kinases consists of two structurally related proteins, ROR1 and ROR2. ROR2 (receptor tyrosine kinase-like orphan receptor 2), also known as neurotrophic tyrosine kinase receptor-related 2 (NTRKR2), is a single pass trans membrane tyrosine-protein kinase receptor. It contains a cytoplasmic tyrosine kinase domain, distally located serine-threonine-rich domains, an extracellular immunoglobulin-like domain, a cysteine-rich domain and a kringle domain. ROR2 is important for skeletal and endocrine development and is required for cartilage and growth plate development. It promotes the differentiation of osteoblasts and plays an important role in the early formation of chondrocytes. ROR2 also interacts with canonical Wnt1 and Wnt3, regulating their signaling pathways. Defects in ROR2 can result in the autosomal dominant skeletal disorder, brachydactylic type B1, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails or the autosomal recessive skeletal disorder, Robinow syndrome which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. ROR2 possesses dual roles in tumorigenesis as a tumor suppressor or activator depending on tumor type. ROR2 expression in primary human Renal Cell Carcinoma (RCC) tumors showed a significant correlation with several Wnt signaling genes, including the classical feedback target gene Axin2.
NCBI Accession NP_004551
UniProt Q01974
Research Area Stem Cells, Extracellular Matrix, Tyrosine Kinases
Pathways RTK Signaling, WNT Signaling

Application Details

Product Details anti-ROR2 Antibody Target Details ROR2 Handling Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Comment

Synonyms: neurotrophic tyrosine kinase receptor-related 2/ NTRKR2

Restrictions For Research Use only

Handling

Product Details anti-ROR2 Antibody Target Details ROR2 Application Details Images back to top
Format Liquid
Concentration 0.55-0.75 μg/μL
Handling Advice Working solutions of antibodies in buffer should be filtered through 0.45 μm filter after every use for long-term storage.
Storage -20 °C
Storage Comment For long-term storage of keep at -20 °C. We don't recommend storage of very dilute antibody solutions unless they are prepared in specially formulated multi use antibody dilution buffer.