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|Antigen||RYK Receptor-Like Tyrosine Kinase (RYK) Antibodies|
|Conjugate||This RYK antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|1 reference available|
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Product Details anti-RYK AntibodyTarget Details RYK Application Details Handling ProductDetails: References for anti-RYK antibody (ABIN359938) Images
|Specificity||This antibody reacts to RYK.|
|Purification||Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human RYK.|
Target Details RYKProduct Details anti-RYK Antibody Application Details Handling ProductDetails: References for anti-RYK antibody (ABIN359938) Images back to top
|Alternative Name||Tyrosine-Protein Kinase RYK (RYK Antibody Abstract)|
|Background||RYK is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. A nine nucleotide insertion in some transcripts results in the SLG variant. It is not established whether this is a product of alternative splicing or a second gene, since evidence for a second gene or pseudogene on chromosome 17 exists.Synonyms: JTK5A|
|Gene ID||6259, 9606|
|Pathways||RTK Signaling, WNT Signaling, Regulation of Cell Size|
Application DetailsProduct Details anti-RYK Antibody Target Details RYK Handling ProductDetails: References for anti-RYK antibody (ABIN359938) Images back to top
ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-RYK Antibody Target Details RYK Application Details ProductDetails: References for anti-RYK antibody (ABIN359938) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
ProductDetails: References for anti-RYK antibody (ABIN359938)Product Details anti-RYK Antibody Target Details RYK Application Details Handling Images back to top
Keeble, Halford, Seaman, Kee, Macheda, Anderson, Stacker, Cooper: "The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 21, pp. 5840-8, 2006
ImagesProduct Details anti-RYK Antibody Target Details RYK Application Details Handling ProductDetails: References for anti-RYK antibody (ABIN359938) back to top