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anti-Human SHC1 antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended SHC1 Antibody (supplied by: Log in to see )

Antigen
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) Antibodies
  • SHC1
  • SHC
  • SHCA
  • P66shc
  • si:dkey-246i14.4
  • wu:fc10h03
  • shc
  • p66shc
  • Shc
  • ShcA
  • p66
  • SHC (Src homology 2 domain containing) transforming protein 1
  • Shc1p
  • squalene--hopene cyclase
  • src homology 2 domain-containing transforming protein C1
  • SHC1
  • shc1
  • LOC100229782
  • Shc1
Epitope
AA 480-520
43
41
19
17
15
15
14
10
9
9
8
7
7
6
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
232
185
143
10
6
6
2
2
1
1
1
Host
Rabbit
215
29
Clonality
Polyclonal
Conjugate
This SHC1 antibody is un-conjugated
7
7
6
5
5
5
5
5
5
5
5
5
5
5
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
170
83
65
61
48
35
11
9
6
4
4
1
1
Options
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Catalog No. ABIN700990
$ 295.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN745973 IF (p) IHC (p) WB Rabbit IgG pTyr349, AA 330-370 Log in to see Polyclonal
1 ABIN745913 IF (p) IHC (p) WB Rabbit IgG AA 25-60, pSer36 Log in to see Polyclonal
1 ABIN879688 IF (p) Alexa Fluor 555 Rabbit IgG pTyr427 Log in to see Polyclonal
1 ABIN2806349 IF (p) Alexa Fluor 594 Rabbit IgG AA 480-520 Log in to see Polyclonal
1 ABIN2806347 IF (p) Alexa Fluor 594 Rabbit IgG pTyr427 Log in to see Polyclonal
1 ABIN2806345 IF (p) Alexa Fluor 594 Rabbit IgG AA 25-60, pSer36 Log in to see Polyclonal
1 ABIN700993 IF (p) Cy3 Rabbit IgG AA 480-520 Log in to see Polyclonal
1 ABIN700994 IF (p) Cy5 Rabbit IgG AA 480-520 Log in to see Polyclonal
1 ABIN700995 IF (p) Cy5.5 Rabbit IgG AA 480-520 Log in to see Polyclonal
1 ABIN700997 IF (p) FITC Rabbit IgG AA 480-520 Log in to see Polyclonal
1 ABIN700996 IF (p) Cy7 Rabbit IgG AA 480-520 Log in to see Polyclonal
1 ABIN745919 IF (p) Cy7 Rabbit IgG AA 25-60, pSer36 Log in to see Polyclonal
1 ABIN745946 IF (p) Cy3 Rabbit IgG pTyr427 Log in to see Polyclonal
1 ABIN745949 IF (p) Cy7 Rabbit IgG pTyr427 Log in to see Polyclonal
1 ABIN745948 IF (p) Cy5.5 Rabbit IgG pTyr427 Log in to see Polyclonal
1 ABIN745950 IF (p) FITC Rabbit IgG pTyr427 Log in to see Polyclonal
1 ABIN915127 IF (p) Alexa Fluor 555 Rabbit IgG AA 480-520 Log in to see Polyclonal
1 ABIN875724 IF (p) Alexa Fluor 488 Rabbit IgG AA 25-60, pSer36 Log in to see Polyclonal
1 ABIN875722 IF (p) Alexa Fluor 555 Rabbit IgG AA 25-60, pSer36 Log in to see Polyclonal
1 ABIN875723 IF (p) Alexa Fluor 350 Rabbit IgG AA 25-60, pSer36 Log in to see Polyclonal

Similar anti-SHC1 Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine)
ELISA 23 Antibodies 33 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies 3 Antibodies
Immunocytochemistry (ICC) 3 Antibodies 6 Antibodies
Immunofluorescence (IF) 17 Antibodies 33 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 66 Antibodies 66 Antibodies
Immunohistochemistry (IHC) 45 Antibodies 49 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 3 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 23 Antibodies
Immunoprecipitation (IP) 8 Antibodies
Western Blotting (WB) 79 Antibodies
Flow Cytometry (FACS) 1 Antibodies

General

Antigen SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) Antibodies
Epitope AA 480-520
(43), (41), (19), (17), (15), (15), (14), (10), (9), (9), (8), (7), (7), (6), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(232), (185), (143), (10), (6), (6), (2), (2), (1), (1), (1)
Host Rabbit
(215), (29)
Clonality
Polyclonal
Conjugate This SHC1 antibody is un-conjugated
(7), (7), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(170), (83), (65), (61), (48), (35), (11), (9), (6), (4), (4), (1), (1)
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Product Details anti-SHC1 Antibody

Target Details SHC1 Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human SHC
Isotype IgG

Target Details SHC1

Product Details anti-SHC1 Antibody Application Details Handling Images back to top
Antigen
Alternative Name Shc (SHC1 Antibody Abstract)
Background

Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.

Subcellular location: Cytoplasm


Synonyms: SHC, SHCA, SHC-transforming protein 1, SHC-transforming protein 3, SHC-transforming protein A, Src homology 2 domain-containing-transforming protein C1, SH2 domain protein C1, SHC1
Gene ID 6464
UniProt P29353
Research Area Signaling, Alzheimer's Disease, Tyrosine Kinases
Pathways RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-SHC1 Antibody Target Details SHC1 Handling Images back to top
Application Notes WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Restrictions For Research Use only

Handling

Product Details anti-SHC1 Antibody Target Details SHC1 Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-SHC1 Antibody Target Details SHC1 Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-SHC1 antibody (SHC (Src Homology 2 Domain Containing) Transforming Protein 1) (AA 480-520) (ABIN700990) Formalin-fixed and paraffin embedded mouse embryo labeled with Rabbit Anti SHC Polycl...
Immunohistochemistry (IHC) image for anti-SHC1 antibody (SHC (Src Homology 2 Domain Containing) Transforming Protein 1) (AA 480-520) (ABIN700990) Formalin-fixed and paraffin embedded rat intestine labeled with Anti-SHC Polyclonal A...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-SHC1 antibody (SHC (Src Homology 2 Domain Containing) Transforming Protein 1) (AA 480-520) (ABIN700990) Formalin-fixed and paraffin embedded mouse embryo labeled with Rabbit Anti SHC Polycl...