anti-Mouse (Murine) SHC1 antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended SHC1 Antibody (supplied by: Log in to see )

Antigen
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) Antibodies
  • SHC1
  • SHC
  • SHCA
  • P66shc
  • si:dkey-246i14.4
  • wu:fc10h03
  • shc
  • p66shc
  • Shc
  • ShcA
  • p66
  • SHC (Src homology 2 domain containing) transforming protein 1
  • Shc1p
  • squalene--hopene cyclase
  • src homology 2 domain-containing transforming protein C1
  • SHC1
  • shc1
  • LOC100229782
  • Shc1
Epitope
AA 25-60, pSer36
43
41
19
16
15
14
14
10
10
8
7
7
5
4
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
232
179
138
10
6
5
2
2
1
1
1
1
1
Host
Rabbit
214
30
Clonality
Polyclonal
Conjugate
This SHC1 antibody is un-conjugated
7
7
6
5
5
5
5
5
5
5
5
5
5
5
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
170
82
65
59
46
37
15
8
6
5
4
3
1
1
Options
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Catalog No. ABIN745913
$ 317.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN700990 IF (p) IHC (p) WB Rabbit IgG AA 480-520 Log in to see Polyclonal
1 ABIN745973 IF (p) IHC (p) WB Rabbit IgG pTyr349, AA 330-370 Log in to see Polyclonal
1 ABIN700993 IF (p) Cy3 Rabbit IgG AA 480-520 Log in to see Polyclonal
1 ABIN700994 IF (p) Cy5 Rabbit IgG AA 480-520 Log in to see Polyclonal
1 ABIN700995 IF (p) Cy5.5 Rabbit IgG AA 480-520 Log in to see Polyclonal
1 ABIN700996 IF (p) Cy7 Rabbit IgG AA 480-520 Log in to see Polyclonal
1 ABIN700997 IF (p) FITC Rabbit IgG AA 480-520 Log in to see Polyclonal
1 ABIN745916 IF (p) Cy3 Rabbit IgG AA 25-60, pSer36 Log in to see Polyclonal
1 ABIN745919 IF (p) Cy7 Rabbit IgG AA 25-60, pSer36 Log in to see Polyclonal
1 ABIN745920 IF (p) FITC Rabbit IgG AA 25-60, pSer36 Log in to see Polyclonal
1 ABIN745918 IF (p) Cy5.5 Rabbit IgG AA 25-60, pSer36 Log in to see Polyclonal
1 ABIN875724 IF (p) Alexa Fluor 488 Rabbit IgG AA 25-60, pSer36 Log in to see Polyclonal
1 ABIN875723 IF (p) Alexa Fluor 350 Rabbit IgG AA 25-60, pSer36 Log in to see Polyclonal
1 ABIN875725 IF (p) Alexa Fluor 647 Rabbit IgG AA 25-60, pSer36 Log in to see Polyclonal
1 ABIN875722 IF (p) Alexa Fluor 555 Rabbit IgG AA 25-60, pSer36 Log in to see Polyclonal
1 ABIN745917 IF (p) Cy5 Rabbit IgG AA 25-60, pSer36 Log in to see Polyclonal
1 ABIN745946 IF (p) Cy3 Rabbit IgG pTyr427 Log in to see Polyclonal
1 ABIN745947 IF (p) Cy5 Rabbit IgG pTyr427 Log in to see Polyclonal
1 ABIN745948 IF (p) Cy5.5 Rabbit IgG pTyr427 Log in to see Polyclonal
1 ABIN745950 IF (p) FITC Rabbit IgG pTyr427 Log in to see Polyclonal

General

Antigen SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) Antibodies
Epitope AA 25-60, pSer36
(43), (41), (19), (16), (15), (14), (14), (10), (10), (8), (7), (7), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(232), (179), (138), (10), (6), (5), (2), (2), (1), (1), (1), (1), (1)
Host Rabbit
(214), (30)
Clonality
Polyclonal
Conjugate This SHC1 antibody is un-conjugated
(7), (7), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(170), (82), (65), (59), (46), (37), (15), (8), (6), (5), (4), (3), (1), (1)
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Product Details anti-SHC1 Antibody

Target Details SHC1 Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from human SHC around the phosphorylation site of Ser36
Isotype IgG

Target Details SHC1

Product Details anti-SHC1 Antibody Application Details Handling Images back to top
Antigen
Alternative Name Shc (SHC1 Antibody Abstract)
Background

Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.

Subcellular location: Cytoplasm

Synonyms: SHC, SHCA, SHC-transforming protein 1, SHC-transforming protein 3, SHC-transforming protein A, Src homology 2 domain-containing-transforming protein C1, SH2 domain protein C1, SHC1

Gene ID 6464
UniProt P29353
Research Area Signaling, Alzheimer's Disease, Tyrosine Kinases
Pathways RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, ER-Nucleus Signaling, Signaling Events mediated by VEGFR1 and VEGFR2

Application Details

Product Details anti-SHC1 Antibody Target Details SHC1 Handling Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-SHC1 Antibody Target Details SHC1 Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-SHC1 Antibody Target Details SHC1 Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 25-60), (pSer36) antibody (ABIN745913) Formalin-fixed and paraffin embedded human rectal carcinoma labeled with Rabbit Anti ...
Immunohistochemistry (IHC) image for anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 25-60), (pSer36) antibody (ABIN745913) Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti phospho-SHC(S...