anti-Human TRKA antibody for Enzyme Immunoassay

Recommended TRKA Antibody (supplied by: Log in to see )

Antigen
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) Antibodies
  • trk
  • trka
  • TRKA
  • MTC
  • TRK
  • TRK1
  • Trk-A
  • p140-TrkA
  • C80751
  • Tkr
  • TrkA
  • Trk
  • CTRKA
  • trkA
  • CAPM1
  • CFTD
  • NEM1
  • OK/SW-cl.5
  • TM-5
  • TM3
  • TM30
  • TM30nm
  • TM5
  • TPMsk3
  • hscp30
  • neurotrophic tyrosine kinase, receptor, type 1
  • tropomyosin 3
  • ntrk1
  • NTRK1
  • LOC100354292
  • Ntrk1
  • TPM3
Epitope
pTyr791
57
26
23
19
18
18
15
15
15
13
13
12
12
12
11
11
10
10
9
9
8
7
7
6
6
6
5
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
430
247
199
2
2
Host
Rabbit
381
73
5
4
3
Clonality
Polyclonal
Conjugate
This TRKA antibody is un-conjugated
17
15
15
12
10
10
9
9
9
9
8
7
7
7
7
7
6
3
2
2
2
2
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
263
148
93
88
67
59
56
43
19
10
5
5
4
3
3
1
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Catalog No. ABIN358249
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN359950 EIA WB Rabbit Ig Middle Region Log in to see Polyclonal 4
1 ABIN453859 EIA WB Rabbit Tyr791 Log in to see Polyclonal 5
1 ABIN272088 EIA IHC (p) WB Rabbit Log in to see Polyclonal

General

Antigen Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) Antibodies
Epitope pTyr791
(57), (26), (23), (19), (18), (18), (15), (15), (15), (13), (13), (12), (12), (12), (11), (11), (10), (10), (9), (9), (8), (7), (7), (6), (6), (6), (5), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(430), (247), (199), (2), (2)
Host Rabbit
(381), (73), (5), (4), (3)
Clonality
Polyclonal
Conjugate This TRKA antibody is un-conjugated
(17), (15), (15), (12), (10), (10), (9), (9), (9), (9), (8), (7), (7), (7), (7), (7), (6), (3), (2), (2), (2), (2), (1)
Application Enzyme Immunoassay (EIA), Western Blotting (WB)
(263), (148), (93), (88), (67), (59), (56), (43), (19), (10), (5), (5), (4), (3), (3), (1)
Pubmed 5 references available
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Product Details anti-TRKA Antibody

Target Details TRKA Application Details Handling References for anti-TRKA antibody (ABIN358249) Images
Specificity This antibody detects TrKA pTyr791.
Purification Protein G Affinity Chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y791 of human TrkA.
Isotype Ig

Target Details TRKA

Product Details anti-TRKA Antibody Application Details Handling References for anti-TRKA antibody (ABIN358249) Images back to top
Antigen
Alternative Name TrkA (NTRK1 Antibody Abstract)
Background TrkA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in the TrkA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.Synonyms: High affinity nerve growth factor receptor, NTRK1, Neurotrophic tyrosine kinase receptor type 1, TRK, TRK1-transforming tyrosine kinase protein, Trk-A, p140-TrkA
Molecular Weight 87511 Da
Gene ID 4914, 9606
UniProt P04629
Research Area Cancer
Pathways RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process

Application Details

Product Details anti-TRKA Antibody Target Details TRKA Handling References for anti-TRKA antibody (ABIN358249) Images back to top
Application Notes ELISA: 1/1,000Western Blot: 1/100-1/500. Dot Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-TRKA Antibody Target Details TRKA Application Details References for anti-TRKA antibody (ABIN358249) Images back to top
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

References for anti-TRKA antibody (ABIN358249)

Product Details anti-TRKA Antibody Target Details TRKA Application Details Handling Images back to top
Background publications

Tacconelli, Farina, Cappabianca, Desantis, Tessitore, Vetuschi, Sferra, Rucci, Argenti, Screpanti, Gulino, Mackay: "TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma." in: Cancer cell, Vol. 6, Issue 4, pp. 347-60, 2004

Frattini, Ferrario, Bressan, Balestra, De Cecco, Mondellini, Bongarzone, Collini, Gariboldi, Pilotti, Pierotti, Greco: "Alternative mutations of BRAF, RET and NTRK1 are associated with similar but distinct gene expression patterns in papillary thyroid cancer." in: Oncogene, Vol. 23, Issue 44, pp. 7436-40, 2004

Flørenes, Maelandsmo, Holm, Reich, Lazarovici, Davidson: "Expression of activated TrkA protein in melanocytic tumors: relationship to cell proliferation and clinical outcome." in: American journal of clinical pathology, Vol. 122, Issue 3, pp. 412-20, 2004

Woo, Lucarelli, Thiele: "NGF activation of TrkA decreases N-myc expression via MAPK path leading to a decrease in neuroblastoma cell number." in: Oncogene, Vol. 23, Issue 8, pp. 1522-30, 2004

Guo, Liao, Soong, Tsai, Niu, Lee, Lin: "Congenital insensitivity to pain with anhidrosis in Taiwan: a morphometric and genetic study." in: European neurology, Vol. 51, Issue 4, pp. 206-14, 2004

Images

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Supplier Images
 image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (pTyr791) antibody (ABIN358249) anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (pTyr791) antibody