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|Antigen||Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) Antibodies|
|Epitope||AA 33-407 Alternatives|
|Conjugate||This TRKA antibody is un-conjugated Alternatives|
Cytometry by Time of Flight (CyTOF), Flow Cytometry (FACS), Immunohistochemistry (IHC), Neutralization (Neut), Western Blotting (WB)
|4 references available|
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Product Details anti-TRKA AntibodyTarget Details TRKA Application Details Handling References for anti-TRKA antibody (ABIN4900238) Images
|Specificity||Detects human TrkA in direct ELISAs and Western blots. In direct ELISAs, approximately 50 % cross-reactivity with recombinant rat TrkA is observed and 10 % cross-reactivity with recombinant human (rh) TrkB and rhTrKC is observed.|
|Sterility||0.2 μm filtered|
|Endotoxin Level||<0.10 EU per 1 μg of the antibody by the LAL method.|
|Immunogen||Mouse myeloma cell line NS0-derived recombinant human TrkA, Ala33-Glu407, Accession # AAA36770|
Target Details TRKAProduct Details anti-TRKA Antibody Application Details Handling References for anti-TRKA antibody (ABIN4900238) Images back to top
|Alternative Name||TrkA (NTRK1 Antibody Abstract)|
|Background||Alternative Names: DKFZp781I14186, EC 2.7.10, EC 18.104.22.168, MTChigh affinity nerve growth factor receptor, Neurotrophic tyrosine kinase receptor type 1, neurotrophic tyrosine kinase, receptor, type 1, NTRK1, NTRK-1, p140-TrkA, TRK1-transforming tyrosine kinase protein, Trk-A, TRKAOncogene TRK, TRKTRK1, tyrosine kinase receptor A|
|Pathways||RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process|
Application DetailsProduct Details anti-TRKA Antibody Target Details TRKA Handling References for anti-TRKA antibody (ABIN4900238) Images back to top
Western Blot 1 μg/mL
Flow Cytometry 2.5 μg/10^6 cells
Immunohistochemistry 5-15 μg/mL
Neutralization 3-12 μg/mL
|Restrictions||For Research Use only|
HandlingProduct Details anti-TRKA Antibody Target Details TRKA Application Details References for anti-TRKA antibody (ABIN4900238) Images back to top
|Reconstitution||Reconstitute at 0.2 mg/mL in sterile PBS.|
|Buffer||Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.|
|Storage||4 °C,-20 °C,-80 °C|
|Storage Comment||Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20°C to -70°C as supplied. 1 month,2°C to 8°C under sterile conditions after reconstitution. 6 months,-20°C to -70°C under sterile conditions after reconstitution.|
|Expiry Date||12 months|
References for anti-TRKA antibody (ABIN4900238)Product Details anti-TRKA Antibody Target Details TRKA Application Details Handling Images back to top
|Product cited in:||
Flowerdew, Wick, Himmelein, Horn, Sinicina, Strupp, Brandt, Theil, Hüfner: "Characterization of neuronal populations in the human trigeminal ganglion and their association with latent herpes simplex virus-1 infection." in: PLoS ONE, Vol. 8, Issue 12, pp. e83603, 2013 Method employed by authors: Immunohistochemistry (IHC) (Sample species: Human).
Huang, Lai, Wu, Cheng, Chiu: "TrkB antibody elicits cytotoxicity and suppresses migration/invasion of transitional cell carcinoma cells." in: International journal of oncology, Vol. 37, Issue 4, pp. 943-9, 2010 Method employed by authors: Functional Studies (Func) (Sample species: Human).
Huang, Lai, Wu, Hsu, Cheng, Lan, Chiu: "BDNF mediated TrkB activation is a survival signal for transitional cell carcinoma cells." in: International journal of oncology, Vol. 36, Issue 6, pp. 1469-76, 2010 Method employed by authors: Immunocytochemistry (ICC) (Sample species: Human).
Sniderhan, Garcia-Bates, Burgart, Bernstein, Phipps, Maggirwar: "Neurotrophin signaling through tropomyosin receptor kinases contributes to survival and proliferation of non-Hodgkin lymphoma." in: Experimental hematology, Vol. 37, Issue 11, pp. 1295-309, 2009 Method employed by authors: Immunocytochemistry (ICC) (Sample species: Human).
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