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anti-Monkey TYRO3 antibody for Enzyme Immunoassay

Recommended TYRO3 Antibody (supplied by: Log in to see )

Antigen
TYRO3 Protein Tyrosine Kinase (TYRO3) Antibodies
  • AI323366
  • brt
  • Brt
  • BYK
  • byk
  • DKFZp469I0432
  • Dtk
  • dtk
  • Etk-2
  • ksy
  • LOC100231598
  • MGC145734
  • REK
  • Rse
  • RSE
  • rse
  • Sky
  • sky
  • tif
  • Tif
  • TYRO3
  • xksy
  • Xksy
Epitope
Extracellular Domain
18
13
13
8
7
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human, Monkey, Mouse (Murine), Rat (Rattus)
165
52
22
3
1
Host
Rabbit
92
72
7
Clonality
Polyclonal
Conjugate
This TYRO3 antibody is un-conjugated
5
4
4
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
122
65
43
39
22
17
14
13
11
10
5
2
1
Supplier
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Catalog No. ABIN493544
$ 456.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008867729 ABIN2734697 EIA WB Rabbit IgG Log in to see Polyclonal

Top referenced anti-TYRO3 antibody for Enzyme Immunoassay

Similar anti-TYRO3 Antibodies

Application / Reactivity Human Mouse (Murine) Monkey Rat (Rattus)
Western Blotting (WB) 121 Antibodies 36 Antibodies 4 Antibodies 13 Antibodies
RNA Interference (RNAi) 2 Antibodies
Luminex Assay (LMNX) 10 Antibodies
Immunoprecipitation (IP) 17 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 22 Antibodies 5 Antibodies 3 Antibodies
Immunohistochemistry (IHC) 38 Antibodies 5 Antibodies 3 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies 11 Antibodies 11 Antibodies
Immunofluorescence (IF) 43 Antibodies 7 Antibodies
Immunocytochemistry (ICC) 14 Antibodies

General

Antigen TYRO3 Protein Tyrosine Kinase (TYRO3) Antibodies
Epitope Extracellular Domain
(18), (13), (13), (8), (7), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Monkey, Mouse (Murine), Rat (Rattus)
(165), (52), (22), (3), (1)
Host Rabbit
(92), (72), (7)
Clonality
Polyclonal
Conjugate This TYRO3 antibody is un-conjugated
(5), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Western Blotting (WB)
(122), (65), (43), (39), (22), (17), (14), (13), (11), (10), (5), (2), (1)
Pubmed 3 references available
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Product Details anti-TYRO3 Antibody

Target Details TYRO3 Application Details Handling References for anti-TYRO3 Antibody (ABIN493544) Images
Specificity This antibody detects a single 100 kDa Tyro3 protein in Tyro3 samples. It also reacts to a 170 kDa MerTk or 95 kDa Axl1-2.
Purification Affinity Chromatography on immobilized antigen
Immunogen Syntehtic peptide corresponding to unique region from the extracytoplasmic domain of the Tyro3 protein. This epitope is conserved in Rat, Mouse and Human Tyro3.
Isotype IgG

Target Details TYRO3

Product Details anti-TYRO3 Antibody Application Details Handling References for anti-TYRO3 Antibody (ABIN493544) Images back to top
Antigen
Alternative Name TYRO3 (TYRO3 Antibody Abstract)
Background The transmembrane signalling by receptor tyrosine kinases invloves the activation of cell surface receptors as a result of ligand binding and subsequenct actviation of cytoplasmic tyrosine kinase domain that resides in the cytoplasmic loop. The tryrosine kinase receptors are critical for cell survival, proliferation and cell differentiation. The Tyro 3 family receptor members include Tyro 3 (also known as Sky, Brt, Tif, Rse, Dtk or Etk), Axl 1/2 (also known as Ark, Ufo, Tyro 7) and Mer (also known as Eyk, Nyk, tyro 12) (1-2). These receptors share distinctive structural domains in the extracellular region, composed of 2 immunoglobulin-related domains linked to 2 fibronectin type III repeats. These structural motifs are characteristics of cell adhesion molecules such as neuronal cell adhesion molecule (involved in proper migration of neuronal crest cells), and protein phosphatase-kappa and m. The growth-arrest specific gene 6 (Gas 6), initially cloned form serum starved 3T3 fibroblast, causes cell cycle re-entry of serum starved 3T3 cells and also prevent them from apoptotic cell death caused by complete serum removal. The Gas 6 has been identified as a common ligand for all Tyro3 family receptor kinases including Mertk, tyro3 and Axl1/2. Triple mutant mouse (Tyro3-/-, Axl-/- , Mer-/-) exhibit multiple major organ defects suggesting their involvement in differentiation and growth. Tyro3 receptors are widely expressed in neuronal tissue, lymphoid, vascular, reproductive and retinal tissues (3). The role of Tyro3 receptors in spermatogenesis is just emerging (4). Tyro3 is a 880-890 aa protein with multiple functional domains characteristics of receptor tyrosine kinases.Synonyms: BYK, DTK, RSE, SKY, Tyrosine-protein kinase receptor TYRO3
Gene ID 7301
NCBI Accession NP_006284
UniProt Q06418
Research Area Signaling, Tyrosine Kinases
Pathways RTK Signaling

Application Details

Product Details anti-TYRO3 Antibody Target Details TYRO3 Handling References for anti-TYRO3 Antibody (ABIN493544) Images back to top
Application Notes Suitable for use in ELISA and Western Blot (1/500).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-TYRO3 Antibody Target Details TYRO3 Application Details References for anti-TYRO3 Antibody (ABIN493544) Images back to top
Concentration 0.65-1.25 mg/mL
Buffer Stabilization buffer
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody undiluted (in aliquots) at-20 °C.

References for anti-TYRO3 Antibody (ABIN493544)

Product Details anti-TYRO3 Antibody Target Details TYRO3 Application Details Handling Images back to top
Background publications

DCruz, Yasumura, Weir, Matthes, Abderrahim, LaVail, Vollrath: "Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat." in: Human molecular genetics, Vol. 9, Issue 4, pp. 645-51, 2000

Gal, Li, Thompson, Weir, Orth, Jacobson, Apfelstedt-Sylla, Vollrath: "Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa." in: Nature genetics, Vol. 26, Issue 3, pp. 270-1, 2000

Ling, Templeton, Kung: "Identification of the major autophosphorylation sites of Nyk/Mer, an NCAM-related receptor tyrosine kinase." in: The Journal of biological chemistry, Vol. 271, Issue 31, pp. 18355-62, 1996

Images

Product Details anti-TYRO3 Antibody Target Details TYRO3 Application Details Handling References for anti-TYRO3 Antibody (ABIN493544) back to top
Supplier Images
 image for anti-TYRO3 antibody (TYRO3 Protein Tyrosine Kinase) (Extracellular Domain) (ABIN493544) anti-TYRO3 Protein Tyrosine Kinase (TYRO3) (Extracellular Domain) antibody