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|Application / Reactivity||Mouse (Murine)||Human|
|ELISA||13 Antibodies||32 Antibodies|
|Enzyme Immunoassay (EIA)||2 Antibodies||2 Antibodies|
|Immunochromatography (IC)||1 Antibodies||3 Antibodies|
|Immunocytochemistry (ICC)||3 Antibodies||6 Antibodies|
|Immunofluorescence (IF)||3 Antibodies||5 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||2 Antibodies||2 Antibodies|
|Immunohistochemistry (IHC)||14 Antibodies||38 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||8 Antibodies|
|Western Blotting (WB)||25 Antibodies|
|Antigen||Caspase Recruitment Domain Family, Member 11 (CARD11) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This CARD11 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|4 references available|
|Supplier||Log in to see|
Product Details anti-CARD11 AntibodyTarget Details CARD11 Application Details Handling References for anti-CARD11 Antibody (ABIN499539) Images
|Specificity||CARMA1 antibody was raised against a synthetic peptide corresponding to amino acids at the C-terminus of human CARMA1.|
|Purification||Affinity chromatography purified via peptide column|
|Immunogen||Human CARMA1 Peptide|
Target Details CARD11Product Details anti-CARD11 Antibody Application Details Handling References for anti-CARD11 Antibody (ABIN499539) Images back to top
|Alternative Name||CARD11 / CARMA1 (CARD11 Antibody Abstract)|
|Background||CARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules (1). CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types (2-4). Both CARMA1 and CARMA3 associate with NEMO, the regulatory subunit of the I?K complex, thereby regulating activation of the NF-kappaB transcription factor (5). Also, gene inactivation studies showed a complete block in T and B cell immunity as well as an impaired response to LPS, indicating that CARMA1 is a critical regulator in both the adaptive and innate immune systems (6).Synonyms: CARD-containing MAGUK protein 3, Caspase recruitment domain-containing protein 11|
|Pathways||TCR Signaling, Fc-epsilon Receptor Signaling Pathway|
Application DetailsProduct Details anti-CARD11 Antibody Target Details CARD11 Handling References for anti-CARD11 Antibody (ABIN499539) Images back to top
ELISA. Western Blot: CARMA1 antibody can be used for detection of CARMA1 at 0.5 to 2 μg/mL. Aband at approximately 125 kDa can be detected. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-CARD11 Antibody Target Details CARD11 Application Details References for anti-CARD11 Antibody (ABIN499539) Images back to top
|Buffer||PBS containing 0.02 % sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store the antibody undiluted at 2-8 °C.|
References for anti-CARD11 Antibody (ABIN499539)Product Details anti-CARD11 Antibody Target Details CARD11 Application Details Handling Images back to top
McAllister-Lucas, Inohara, Lucas et al.: "Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction." in: The Journal of biological chemistry, Vol. 276, Issue 33, pp. 30589-97, 2001 (PubMed).
Gaide, Martinon, Micheau et al.: "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation." in: FEBS letters, Vol. 496, Issue 2-3, pp. 121-7, 2001 (PubMed).
Bertin, Wang, Guo et al.: "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B." in: The Journal of biological chemistry, Vol. 276, Issue 15, pp. 11877-82, 2001 (PubMed).
Fanning, Anderson: "Protein modules as organizers of membrane structure." in: Current opinion in cell biology, Vol. 11, Issue 4, pp. 432-9, 1999 (PubMed).
ImagesProduct Details anti-CARD11 Antibody Target Details CARD11 Application Details Handling References for anti-CARD11 Antibody (ABIN499539) back to top