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anti-Human CD4 antibody for Biochemical Assay

Recommended CD4 Antibody (supplied by: Log in to see )

Antigen
CD4 Molecule (CD4) Antibodies
  • cd4
  • CD4mut
  • L3T4
  • Ly-4
  • p55
  • W3/25
Reactivity
Human
1197
691
240
66
52
45
25
23
22
21
19
15
14
9
9
8
7
7
7
7
6
5
5
5
3
2
2
2
1
1
1
Host
Mouse
1358
664
276
4
2
1
Clonality
Monoclonal
Conjugate
This CD4 antibody is conjugated to PE-Cy5
282
237
175
114
44
42
42
39
38
38
36
32
26
24
22
22
21
20
19
19
19
19
19
16
15
13
9
8
8
8
7
7
5
5
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Biochemical Assay (BCA)
1803
436
395
352
309
297
179
136
100
70
33
28
28
27
22
18
14
11
10
8
7
6
6
6
5
5
4
3
2
2
2
2
2
2
1
1
1
1
1
1
1
Supplier
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Catalog No. ABIN2658970
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008862732 ABIN2660679 BCA APC-Cy7 Mouse IgG1 kappa Log in to see SK3 5
0.0008862732 ABIN2658651 BCA APC Mouse IgG1 kappa Log in to see SK3 5
0.0008862732 ABIN2658971 BCA PE-Cy5 Mouse IgG1 kappa Log in to see RPA-T4 10
0.0008862732 ABIN2660680 BCA APC-Cy7 Mouse IgG1 kappa Log in to see SK3 5
0.0008862732 ABIN2658652 BCA APC Mouse IgG1 kappa Log in to see SK3 5

Top referenced anti-CD4 antibody for Biochemical Assay

Similar anti-CD4 Antibodies

Application / Reactivity Human
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Biochemical Assay (BCA) 6 Antibodies
Blocking Antibody (Inhibition) 1 Antibodies
Blocking Reagent (BR) 9 Antibodies
Complement Mediated Cell Depletion (CMCD) 2 Antibodies
Depletion (Dep) 4 Antibodies
ELISA 249 Antibodies
ELISA (Capture) 1 Antibodies
ELISA (Detection) 1 Antibodies
ELISpot (Detection) (ELISPOT (Detection)) 1 Antibodies
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Immunochromatography (IC) 3 Antibodies
Immunocytochemistry (ICC) 43 Antibodies

General

Antigen CD4 Molecule (CD4) Antibodies
Reactivity Human
(1197), (691), (240), (66), (52), (45), (25), (23), (22), (21), (19), (15), (14), (9), (9), (8), (7), (7), (7), (7), (6), (5), (5), (5), (3), (2), (2), (2), (1), (1), (1)
Host Mouse
(1358), (664), (276), (4), (2), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CD4 antibody is conjugated to PE-Cy5
(282), (237), (175), (114), (44), (42), (42), (39), (38), (38), (36), (32), (26), (24), (22), (22), (21), (20), (19), (19), (19), (19), (19), (16), (15), (13), (9), (8), (8), (8), (7), (7), (5), (5), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Biochemical Assay (BCA)
(1803), (436), (395), (352), (309), (297), (179), (136), (100), (70), (33), (28), (28), (27), (22), (18), (14), (11), (10), (8), (7), (6), (6), (6), (5), (5), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 10 references available
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Product Details anti-CD4 Antibody

Target Details CD4 Application Details Handling References for anti-CD4 Antibody (ABIN2658970) Images
Cross-Reactivity Chimpanzee
Purification The antibody was purified by affinity chromatography, and conjugated with PE/Cy5 under optimal conditions. The solution is free of unconjugated PE/Cy5 and unconjugated antibody.
Clone RPA-T4
Isotype IgG1 kappa

Target Details CD4

Product Details anti-CD4 Antibody Application Details Handling References for anti-CD4 Antibody (ABIN2658970) Images back to top
Antigen
Alternative Name CD4 (CD4 Antibody Abstract)
Background CD4, also known as T4, is a 55 kD single-chain type I transmembrane glycoprotein expressed on most thymocytes, a subset of T cells, and monocytes/macrophages. CD4, a member of the Ig superfamily, recognizes antigens associated with MHC class II molecules, and participates in cell-cell interactions, thymic differentiation, and signal transduction. CD4 acts as a primary receptor for HIV, binding to HIV gp120. CD4 has also been shown to interact with IL-16.
Research Area Immunology, Adaptive Immunity, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells
Pathways TCR Signaling

Application Details

Product Details anti-CD4 Antibody Target Details CD4 Handling References for anti-CD4 Antibody (ABIN2658970) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-CD4 Antibody Target Details CD4 Application Details References for anti-CD4 Antibody (ABIN2658970) Images back to top
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-CD4 Antibody (ABIN2658970)

Product Details anti-CD4 Antibody Target Details CD4 Application Details Handling Images back to top
Background publications

ORegan, Steinfelder, Venugopal, Rao, Lucius, Srikantam, Hartmann: "Brugia malayi microfilariae induce a regulatory monocyte/macrophage phenotype that suppresses innate and adaptive immune responses." in: PLoS neglected tropical diseases, Vol. 8, Issue 10, pp. e3206, 2014

Zenaro, Donini, Dusi: "Induction of Th1/Th17 immune response by Mycobacterium tuberculosis: role of dectin-1, Mannose Receptor, and DC-SIGN." in: Journal of leukocyte biology, Vol. 86, Issue 6, pp. 1393-401, 2009

Lan, Cheng, Lian, Tsuneyama, Yang, Moritoki, Chuang, Nakamura, Saito, Shimoda, Tanaka, Bowlus, Takano, Ansari, Coppel, Gershwin: "Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis." in: Hepatology (Baltimore, Md.), Vol. 43, Issue 4, pp. 729-37, 2006

Mack, Tucker, Sokol, Karrer, Kotzin, Whitington, Miller: "Biliary atresia is associated with CD4+ Th1 cell-mediated portal tract inflammation." in: Pediatric research, Vol. 56, Issue 1, pp. 79-87, 2004

Yoshino, Ami, Terao, Tashiro, Honda: "Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies." in: Experimental animals / Japanese Association for Laboratory Animal Science, Vol. 49, Issue 2, pp. 97-110, 2000

Friedman, Shimizu, Smith, Colvin, Seebach, Sachs, Iacomini: "Human CD4+ T cells mediate rejection of porcine xenografts." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 9, pp. 5256-62, 1999

Moir, Lapointe, Malaspina, Ostrowski, Cole, Chun, Adelsberger, Baseler, Hwu, Fauci et al.: "CD40-Mediated induction of CD4 and CXCR4 on B lymphocytes correlates with restricted susceptibility to human immunodeficiency virus type 1 infection: potential role of B lymphocytes as a viral ..." in: Journal of virology, Vol. 73, Issue 10, pp. 7972-80, 1999

Center, Kornfeld, Cruikshank: "Interleukin 16 and its function as a CD4 ligand." in: Immunology today, Vol. 17, Issue 10, pp. 476-81, 1997

Gaubin, Autiero, Houlgatte, Basmaciogullari, Auffray, Piatier-Tonneau: "Molecular basis of T lymphocyte CD4 antigen functions." in: European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, Vol. 34, Issue 9, pp. 723-8, 1997

Deng, Bell, Huie, Pinto, Hunt, Stinson, Sibley, Hall, Valantine: "Cardiac allograft vascular disease. Relationship to microvascular cell surface markers and inflammatory cell phenotypes on endomyocardial biopsy." in: Circulation, Vol. 91, Issue 6, pp. 1647-54, 1995

Images

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Supplier Images
Flow Cytometry (FACS) image for anti-CD4 antibody (CD4 Molecule)  (PE-Cy5) (ABIN2658970) anti-CD4 Molecule (CD4) antibody (PE-Cy5)