anti-Human CD4 antibody for Biochemical Assay

Recommended CD4 Antibody (supplied by: Log in to see )

Antigen
CD4 Molecule (CD4) Antibodies
  • cd4
  • L3T4
  • Ly-4
  • CD4mut
  • W3/25
  • p55
  • CD4 molecule
  • CD4 antigen
  • T-cell surface glycoprotein CD4
  • Cd4 molecule
  • CD4
  • cd4
  • Cd4
Reactivity
Human
1250
656
235
78
68
41
36
28
27
26
22
21
19
16
15
15
13
10
10
9
7
6
5
5
5
4
4
3
3
3
3
2
2
2
2
2
1
1
1
1
Host
Mouse
1421
611
283
16
6
1
1
1
Clonality
Monoclonal
Conjugate
This CD4 antibody is conjugated to PE-Cy5
264
232
170
108
54
54
54
48
36
34
33
33
30
26
22
21
21
20
19
19
18
18
18
18
16
15
15
13
13
9
9
8
8
6
5
5
4
4
4
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Biochemical Assay (BCA)
1823
495
453
353
323
311
161
156
98
78
41
39
38
30
30
25
18
14
14
11
9
8
6
6
5
4
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
Supplier
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Catalog No. ABIN2658970
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2660679 BCA APC-Cy7 Mouse IgG1 kappa Log in to see SK3 5
1 ABIN2658651 BCA APC Mouse IgG1 kappa Log in to see SK3 5
1 ABIN2658971 BCA PE-Cy5 Mouse IgG1 kappa Log in to see RPA-T4 10
1 ABIN2660680 BCA APC-Cy7 Mouse IgG1 kappa Log in to see SK3 5
1 ABIN2658652 BCA APC Mouse IgG1 kappa Log in to see SK3 5

General

Antigen CD4 Molecule (CD4) Antibodies
Reactivity Human
(1250), (656), (235), (78), (68), (41), (36), (28), (27), (26), (22), (21), (19), (16), (15), (15), (13), (10), (10), (9), (7), (6), (5), (5), (5), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Host Mouse
(1421), (611), (283), (16), (6), (1), (1), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CD4 antibody is conjugated to PE-Cy5
(264), (232), (170), (108), (54), (54), (54), (48), (36), (34), (33), (33), (30), (26), (22), (21), (21), (20), (19), (19), (18), (18), (18), (18), (16), (15), (15), (13), (13), (9), (9), (8), (8), (6), (5), (5), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Biochemical Assay (BCA)
(1823), (495), (453), (353), (323), (311), (161), (156), (98), (78), (41), (39), (38), (30), (30), (25), (18), (14), (14), (11), (9), (8), (6), (6), (5), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Pubmed 10 references available
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Product Details anti-CD4 Antibody

Target Details CD4 Application Details Handling References for anti-CD4 antibody (ABIN2658970) Images
Cross-Reactivity Chimpanzee
Purification The antibody was purified by affinity chromatography, and conjugated with PE/Cy5 under optimal conditions. The solution is free of unconjugated PE/Cy5 and unconjugated antibody.
Clone RPA-T4
Isotype IgG1 kappa

Target Details CD4

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Antigen
Alternative Name CD4 (CD4 Antibody Abstract)
Background CD4, also known as T4, is a 55 kD single-chain type I transmembrane glycoprotein expressed on most thymocytes, a subset of T cells, and monocytes/macrophages. CD4, a member of the Ig superfamily, recognizes antigens associated with MHC class II molecules, and participates in cell-cell interactions, thymic differentiation, and signal transduction. CD4 acts as a primary receptor for HIV, binding to HIV gp120. CD4 has also been shown to interact with IL-16.
Research Area Immunology, Adaptive Immunity, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells
Pathways TCR Signaling, Maintenance of Protein Location, CXCR4-mediated Signaling Events

Application Details

Product Details anti-CD4 Antibody Target Details CD4 Handling References for anti-CD4 antibody (ABIN2658970) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-CD4 Antibody Target Details CD4 Application Details References for anti-CD4 antibody (ABIN2658970) Images back to top
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-CD4 antibody (ABIN2658970)

Product Details anti-CD4 Antibody Target Details CD4 Application Details Handling Images back to top
Background publications

ORegan, Steinfelder, Venugopal, Rao, Lucius, Srikantam, Hartmann: "Brugia malayi microfilariae induce a regulatory monocyte/macrophage phenotype that suppresses innate and adaptive immune responses." in: PLoS neglected tropical diseases, Vol. 8, Issue 10, pp. e3206, 2014

Zenaro, Donini, Dusi: "Induction of Th1/Th17 immune response by Mycobacterium tuberculosis: role of dectin-1, Mannose Receptor, and DC-SIGN." in: Journal of leukocyte biology, Vol. 86, Issue 6, pp. 1393-401, 2009

Lan, Cheng, Lian, Tsuneyama, Yang, Moritoki, Chuang, Nakamura, Saito, Shimoda, Tanaka, Bowlus, Takano, Ansari, Coppel, Gershwin: "Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis." in: Hepatology (Baltimore, Md.), Vol. 43, Issue 4, pp. 729-37, 2006

Mack, Tucker, Sokol, Karrer, Kotzin, Whitington, Miller: "Biliary atresia is associated with CD4+ Th1 cell-mediated portal tract inflammation." in: Pediatric research, Vol. 56, Issue 1, pp. 79-87, 2004

Yoshino, Ami, Terao, Tashiro, Honda: "Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies." in: Experimental animals / Japanese Association for Laboratory Animal Science, Vol. 49, Issue 2, pp. 97-110, 2000

Friedman, Shimizu, Smith, Colvin, Seebach, Sachs, Iacomini: "Human CD4+ T cells mediate rejection of porcine xenografts." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 9, pp. 5256-62, 1999

Moir, Lapointe, Malaspina, Ostrowski, Cole, Chun, Adelsberger, Baseler, Hwu, Fauci et al.: "CD40-Mediated induction of CD4 and CXCR4 on B lymphocytes correlates with restricted susceptibility to human immunodeficiency virus type 1 infection: potential role of B lymphocytes as a viral ..." in: Journal of virology, Vol. 73, Issue 10, pp. 7972-80, 1999

Center, Kornfeld, Cruikshank: "Interleukin 16 and its function as a CD4 ligand." in: Immunology today, Vol. 17, Issue 10, pp. 476-81, 1997

Gaubin, Autiero, Houlgatte, Basmaciogullari, Auffray, Piatier-Tonneau: "Molecular basis of T lymphocyte CD4 antigen functions." in: European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, Vol. 34, Issue 9, pp. 723-8, 1997

Deng, Bell, Huie, Pinto, Hunt, Stinson, Sibley, Hall, Valantine: "Cardiac allograft vascular disease. Relationship to microvascular cell surface markers and inflammatory cell phenotypes on endomyocardial biopsy." in: Circulation, Vol. 91, Issue 6, pp. 1647-54, 1995

Images

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Supplier Images
Flow Cytometry (FACS) image for anti-CD4 Molecule (CD4) antibody (PE-Cy5) (ABIN2658970) anti-CD4 Molecule (CD4) antibody (PE-Cy5)