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anti-Human CD4 antibody for Neutralization

Recommended CD4 Antibody (supplied by: Log in to see )

Antigen
CD4 Molecule (CD4) Antibodies
  • cd4
  • L3T4
  • Ly-4
  • CD4mut
  • W3/25
  • p55
  • CD4 molecule
  • CD4 antigen
  • T-cell surface glycoprotein CD4
  • Cd4 molecule
  • CD4
  • cd4
  • Cd4
Reactivity
Human
1188
667
252
72
61
43
34
24
22
22
19
17
16
15
11
11
10
10
9
7
6
6
5
5
4
2
2
2
1
1
1
1
Host
Mouse
1358
627
272
9
4
1
Clonality
Monoclonal
Conjugate
This CD4 antibody is un-conjugated
281
239
171
106
47
45
43
36
36
35
34
32
25
25
21
21
20
19
18
18
18
18
16
15
13
13
12
10
8
8
7
6
6
6
5
4
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Application
Blocking Peptide (BP), Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), In vitro Assay (in vitro), Neutralization (Neut)
1754
467
442
329
314
298
151
150
85
61
39
38
29
29
29
21
19
18
14
14
11
9
7
6
6
6
5
4
4
3
2
2
2
2
2
2
1
1
1
1
1
1
Supplier
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Catalog No. ABIN4292796
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN4292810 BP FACS IHC IHC (fro) Neut DyLight 405 Mouse IgG1 kappa Log in to see RPA-T4
1 ABIN4292815 BP FACS IHC IHC (fro) Neut Alexa Fluor 700 Mouse IgG1 kappa Log in to see RPA-T4
1 ABIN4292801 BP CyTOF FACS ICC IF IHC IHC (fro) Neut Mouse IgG1 kappa Log in to see RPA-T4
1 ABIN961119 FACS IHC Neut Mouse IgG1, kappa Log in to see RPA-T4
1 ABIN206939 Inhibition BR FACS Func IP Neut Mouse IgG2a Log in to see MEM-115
1 ABIN1831271 FACS Neut IHC Mouse IgG1, kappa Log in to see 11E59
1 ABIN206889 Inhibition BR FACS Func IP Neut Mouse IgG2a Log in to see MEM-115
1 ABIN4292795 BP FACS IHC IHC (fro) in vitro Neut Mouse IgG1 kappa Log in to see RPA-T4
1 ABIN4292875 BP CyTOF ELISA FACS IHC Neut Rabbit IgG Log in to see CE9-1 (Clenoliximab)
1 ABIN4292874 BP CyTOF ELISA FACS IHC Neut Rabbit IgG Log in to see CE9-1 (Clenoliximab)
1 ABIN4292805 BP FACS IHC IHC (fro) Neut DyLight 488 Mouse IgG1 kappa Log in to see RPA-T4
1 ABIN4292804 BP FACS IHC IHC (fro) Neut DyLight 680 Mouse IgG1 kappa Log in to see RPA-T4
1 ABIN4292803 BP FACS IHC IHC (fro) Neut DyLight 650 Mouse IgG1 kappa Log in to see RPA-T4
1 ABIN4292806 BP FACS IHC IHC (fro) Neut DyLight 755 Mouse IgG1 kappa Log in to see RPA-T4
1 ABIN4292808 BP FACS IHC IHC (fro) Neut DyLight 550 Mouse IgG1 kappa Log in to see RPA-T4
1 ABIN4292813 BP FACS IHC IHC (fro) Neut Alexa Fluor 488 Mouse IgG1 kappa Log in to see RPA-T4
1 ABIN4292807 BP FACS IHC IHC (fro) Neut PerCP Mouse IgG1 kappa Log in to see RPA-T4
1 ABIN4292809 BP FACS IHC IHC (fro) Neut DyLight 350 Mouse IgG1 kappa Log in to see RPA-T4
1 ABIN4292812 BP FACS IHC IHC (fro) Neut Alexa Fluor 405 Mouse IgG1 kappa Log in to see RPA-T4
1 ABIN4292814 BP FACS IHC IHC (fro) Neut Alexa Fluor 647 Mouse IgG1 kappa Log in to see RPA-T4

Top referenced anti-CD4 antibody for Neutralization

Similar anti-CD4 Antibodies

Application / Reactivity Human
Activation (Act) 3 Antibodies
Biochemical Assay (BCA) 6 Antibodies
Blocking Antibody (Inhibition) 4 Antibodies
Blocking Peptide (BP) 19 Antibodies
Blocking Reagent (BR) 11 Antibodies
Complement Mediated Cell Depletion (CMCD) 2 Antibodies
Cytometry by Time of Flight (CyTOF) 17 Antibodies
Depletion (Dep) 4 Antibodies
ELISA 251 Antibodies
ELISA (Capture) 1 Antibodies
ELISA (Detection) 1 Antibodies
ELISpot (Detection) (ELISPOT (Detection)) 1 Antibodies
Enzyme Immunoassay (EIA) 6 Antibodies
Flow Cytometry (FACS) 792 Antibodies
Functional Studies (Func) 30 Antibodies
Immunochromatography (IC) 3 Antibodies
Immunocytochemistry (ICC) 39 Antibodies

General

Antigen CD4 Molecule (CD4) Antibodies
Reactivity Human
(1188), (667), (252), (72), (61), (43), (34), (24), (22), (22), (19), (17), (16), (15), (11), (11), (10), (10), (9), (7), (6), (6), (5), (5), (4), (2), (2), (2), (1), (1), (1), (1)
Host Mouse
(1358), (627), (272), (9), (4), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CD4 antibody is un-conjugated
(281), (239), (171), (106), (47), (45), (43), (36), (36), (35), (34), (32), (25), (25), (21), (21), (20), (19), (18), (18), (18), (18), (16), (15), (13), (13), (12), (10), (8), (8), (7), (6), (6), (6), (5), (4), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Application Blocking Peptide (BP), Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), In vitro Assay (in vitro), Neutralization (Neut)
(1754), (467), (442), (329), (314), (298), (151), (150), (85), (61), (39), (38), (29), (29), (29), (21), (19), (18), (14), (14), (11), (9), (7), (6), (6), (6), (5), (4), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Pubmed 11 references available
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Product Details anti-CD4 Antibody

Target Details CD4 Application Details Handling References for anti-CD4 Antibody (ABIN4292796) Images
Purification Protein G purified
Immunogen PHA-stimulated human PBMC.
Clone RPA-T4
Isotype IgG1 kappa

Target Details CD4

Product Details anti-CD4 Antibody Application Details Handling References for anti-CD4 Antibody (ABIN4292796) Images back to top
Antigen
Alternative Name CD4 (CD4 Antibody Abstract)
Background Gene Symbol: CD4
Gene ID 920
NCBI Accession NP_000607
Research Area Adaptive Immunity, Immunology, Hematopoietic Progenitors, Surface Receptors of Immune Cells, CD Antigens
Pathways TCR Signaling

Application Details

Product Details anti-CD4 Antibody Target Details CD4 Handling References for anti-CD4 Antibody (ABIN4292796) Images back to top
Application Notes Flow Cytometry, Immunohistochemistry 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500, In vitro assay, Blocking/Neutralizing 50-200 Molar excessRPA-T4 is capable of blocking HIV-1, gp120, and inhibits syncytium formation. The RPA-T4 clone reacts with CD4, a 59 kDa single-chain transmembrane glycoprotein [receptor for human HIV virus] present on T-helper/inducer cell populations. This antibody binds to the D1 domain of CDR1 and CDR3 epitopes. The CD4 antigen and reacts with approvimately 80 % of thymocytes and 45 % of peripheral blood lymphocytes. CD4 is also present in low density on peripheral blood monocytes. Clone RPA-T4 is widely published in literature, see Knapp W, Dorken B, Rieber E P, et all, ed. Also see Schlossman SF, Boumsell L, Gilks W, et al, ed.. Use in in vitro reported in multiple pieces scientific literature.

Not for use in: Immunohistochemistry-Paraffin
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only

Handling

Product Details anti-CD4 Antibody Target Details CD4 Application Details References for anti-CD4 Antibody (ABIN4292796) Images back to top
Format Liquid
Concentration 0.5 mg/mL
Buffer 0.2 mL PBS and 0.05 % BSA
Buffer contains: 0.05 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

References for anti-CD4 Antibody (ABIN4292796)

Product Details anti-CD4 Antibody Target Details CD4 Application Details Handling Images back to top
Product cited in:

Staal, Res, Weijer, Spits: "Development of retrovirally marked human T progenitor cells into mature thymocytes." in: International immunology, Vol. 7, Issue 8, pp. 1301-9, 1996

Ruggiero, Martinez Cáceres, Voordouw, Noteboom, Graf, Kroczek, Spits: "CD40 expressed on thymic epithelial cells provides costimulation for proliferation but not for apoptosis of human thymocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 156, Issue 10, pp. 3737-46, 1996

Res, Martínez-Cáceres, Cristina Jaleco, Staal, Noteboom, Weijer, Spits: "CD34+CD38dim cells in the human thymus can differentiate into T, natural killer, and dendritic cells but are distinct from pluripotent stem cells." in: Blood, Vol. 87, Issue 12, pp. 5196-206, 1996 (Sample species: Human). Further details: Flow Cytometry

Schols, De Clercq: "Human immunodeficiency virus type 1 gp120 induces anergy in human peripheral blood lymphocytes by inducing interleukin-10 production." in: Journal of virology, Vol. 70, Issue 8, pp. 4953-60, 1996 (Sample species: Human). Further details: In vitro Assay

Kaneko, Saito, Hashimoto, Yagita, Okumura, Azuma: "Preferential elimination of CD28+ T cells in systemic lupus erythematosus (SLE) and the relation with activation-induced apoptosis." in: Clinical and experimental immunology, Vol. 106, Issue 2, pp. 218-29, 1996

Deng, Bell, Huie, Pinto, Hunt, Stinson, Sibley, Hall, Valantine: "Cardiac allograft vascular disease. Relationship to microvascular cell surface markers and inflammatory cell phenotypes on endomyocardial biopsy." in: Circulation, Vol. 91, Issue 6, pp. 1647-54, 1995 (Sample species: Human). Further details: Immunohistochemistry (Frozen Sections)

Aversa, Waugh, Hall: "A monoclonal antibody (A6) recognizing a unique epitope restricted to CD45RO and RB isoforms of the leukocyte common antigen family identifies functional T cell subsets." in: Cellular immunology, Vol. 158, Issue 2, pp. 314-28, 1994 (Sample species: Human). Further details: In vitro Assay

Bárcena, Muench, Galy, Cupp, Roncarolo, Phillips, Spits: "Phenotypic and functional analysis of T-cell precursors in the human fetal liver and thymus: CD7 expression in the early stages of T- and myeloid-cell development." in: Blood, Vol. 82, Issue 11, pp. 3401-14, 1994 (Sample species: Human). Further details: Flow Cytometry

Chabanne, Marchal, Kaplanski, Fournel, Magnol, Monier, Rigal: "Screening of 78 monoclonal antibodies directed against human leukocyte antigens for cross-reactivity with surface markers on canine lymphocytes." in: Tissue antigens, Vol. 43, Issue 3, pp. 202-5, 1994

Galy, Verma, Bárcena, Spits: "Precursors of CD3+CD4+CD8+ cells in the human thymus are defined by expression of CD34. Delineation of early events in human thymic development." in: The Journal of experimental medicine, Vol. 178, Issue 2, pp. 391-401, 1993 (Sample species: Human). Further details: In vitro Assay,Flow Cytometry

Wilson, Crowley, Odgers, Shaw: "Immunofluorescent labeling using covalently linked anti-phycoerythrin antibodies and phycoerythrin polymers." in: Cytometry, Vol. 12, Issue 4, pp. 373-7, 1991

Images

Product Details anti-CD4 Antibody Target Details CD4 Application Details Handling References for anti-CD4 Antibody (ABIN4292796) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-CD4 antibody (CD4 Molecule) (ABIN4292796) Flow Cytometry: CD4 Antibody (RPA-T4) [NBP2-25199] - Cell surface flow analysis of CD...
Flow Cytometry (FACS) image for anti-CD4 antibody (CD4 Molecule) (ABIN4292796) Flow Cytometry: CD4 Antibody (RPA-T4) [NBP2-25199] - Analysis using Azide Free versio...