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|Application / Reactivity||Mouse (Murine)|
|Biochemical Assay (BCA)||3 Antibodies|
|Blocking Reagent (BR)||15 Antibodies|
|Cytotoxicity Test (CyTox)||7 Antibodies|
|Depletion (Dep)||2 Antibodies|
|ELISA (Capture)||2 Antibodies|
|Enzyme Immunoassay (EIA)||3 Antibodies|
|Flow Cytometry (FACS)||469 Antibodies|
|Functional Studies (Func)||29 Antibodies|
|Immunochromatography (IC)||2 Antibodies|
|Immunocytochemistry (ICC)||35 Antibodies|
|Immunofluorescence (IF)||64 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||22 Antibodies|
|Immunohistochemistry (IHC)||100 Antibodies|
|Immunohistochemistry (Acetone-fixed) (IHC (af))||10 Antibodies|
|Immunohistochemistry (Formalin-fixed Sections) (IHC (f))||7 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||56 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||15 Antibodies|
|Immunohistochemistry (Zinc-fixed Sections) (IHC (zinc))||5 Antibodies|
|Antigen||CD4 Molecule (CD4) Antibodies|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This CD4 antibody is conjugated to APC-Cy7 Alternatives|
ELISA (Capture), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
|8 references available|
|Supplier||Log in to see|
Product Details anti-CD4 AntibodyTarget Details CD4 Application Details Handling References for anti-CD4 Antibody (ABIN2660685) Images
|Purification||The antibody was purified by affinity chromatography, and conjugated with APC/Cy7 under optimal conditions. The solution is free of unconjugated APC/Cy7 and unconjugated antibody.|
Target Details CD4Product Details anti-CD4 Antibody Application Details Handling References for anti-CD4 Antibody (ABIN2660685) Images back to top
|Alternative Name||CD4 (CD4 Antibody Abstract)|
|Background||CD4 is a 55 kD protein also known as L3T4 or T4. It is a member of the Ig superfamily, primarily expressed on most thymocytes and a subset of T cells, and weakly on macrophages and dendritic cells. It acts as a co-receptor with the TCR during T cell activation and thymic differentiation by binding MHC class II and associating with the protein tyrosine kinase lck.|
|Research Area||Immunology, Adaptive Immunity, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells|
Application DetailsProduct Details anti-CD4 Antibody Target Details CD4 Handling References for anti-CD4 Antibody (ABIN2660685) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-CD4 Antibody Target Details CD4 Application Details References for anti-CD4 Antibody (ABIN2660685) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Protect from prolonged exposure to light. Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-CD4 Antibody (ABIN2660685)Product Details anti-CD4 Antibody Target Details CD4 Application Details Handling Images back to top
Zaborsky, Brunner, Wallner et al.: "Antigen aggregation decides the fate of the allergic immune response." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 2, pp. 725-35, 2010 (PubMed).
Shigeta, Matsumoto, Tedder et al.: "An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation." in: Blood, Vol. 112, Issue 13, pp. 4915-23, 2008 (PubMed).
Matsumoto, Shigeta, Furukawa et al.: "CD43 collaborates with P-selectin glycoprotein ligand-1 to mediate E-selectin-dependent T cell migration into inflamed skin." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 4, pp. 2499-506, 2007 (PubMed).
León-Ponte, Ahern, OConnell: "Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor." in: Blood, Vol. 109, Issue 8, pp. 3139-46, 2007 (PubMed).
Muraille, De Trez, Pajak et al.: "Amastigote load and cell surface phenotype of infected cells from lesions and lymph nodes of susceptible and resistant mice infected with Leishmania major." in: Infection and immunity, Vol. 71, Issue 5, pp. 2704-15, 2003 (PubMed).
Fan, Kouda, Nakamura et al.: "Effects of dietary restriction on spontaneous dermatitis in NC/Nga mice." in: Experimental biology and medicine (Maywood, N.J.), Vol. 226, Issue 11, pp. 1045-50, 2001 (PubMed).
Bierer, Sleckman, Ratnofsky et al.: "The biologic roles of CD2, CD4, and CD8 in T-cell activation." in: Annual review of immunology, Vol. 7, pp. 579-99, 1989 (PubMed).
Janeway: "The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation." in: Annual review of immunology, Vol. 10, pp. 645-74, 1992 (PubMed).
ImagesProduct Details anti-CD4 Antibody Target Details CD4 Application Details Handling References for anti-CD4 Antibody (ABIN2660685) back to top