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anti-Human ICOS antibody for Blocking Reagent

Recommended ICOS Antibody (supplied by: Log in to see )

Antigen
Inducible T-Cell Co-Stimulator (ICOS) Antibodies
  • AILIM
  • Ailim
  • CCLP
  • CD278
  • CRP-1
  • CVID1
  • H4
  • ICOS
  • Ly115
Reactivity
Human, Mouse (Murine), Rat (Rattus)
60
56
41
1
Host
Hamster
34
24
13
10
2
1
Clonality
Monoclonal
Conjugate
This ICOS antibody is conjugated to PerCP-Cy5.5
10
8
7
5
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Activation (Act), Blocking Reagent (BR), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
43
14
14
11
9
7
5
4
4
3
3
2
2
2
1
1
1
1
Supplier
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Catalog No. ABIN2660067
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008676689 ABIN2660068 Act BR FACS IP IHC WB PerCP-Cy5.5 Hamster IgG Log in to see C398-4A 9

Top referenced anti-ICOS antibody for Blocking Reagent

Similar anti-ICOS Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine)
Activation (Act) 2 Antibodies 2 Antibodies
Blocking Reagent (BR) 2 Antibodies 3 Antibodies
ELISA 3 Antibodies 2 Antibodies
Flow Cytometry (FACS) 21 Antibodies
Immunochromatography (IC) 1 Antibodies
Immunocytochemistry (ICC) 1 Antibodies
Immunofluorescence (IF) 2 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 6 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 4 Antibodies
Immunoprecipitation (IP) 3 Antibodies
Intracellular Flow Cytometry (ICFC) 4 Antibodies
Western Blotting (WB) 10 Antibodies
ELISA (Capture) 1 Antibodies
ELISA (Detection) 4 Antibodies

General

Antigen Inducible T-Cell Co-Stimulator (ICOS) Antibodies
Reactivity Human, Mouse (Murine), Rat (Rattus)
(60), (56), (41), (1)
Host Hamster
(34), (24), (13), (10), (2), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This ICOS antibody is conjugated to PerCP-Cy5.5
(10), (8), (7), (5), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Activation (Act), Blocking Reagent (BR), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(43), (14), (14), (11), (9), (7), (5), (4), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1)
Pubmed 9 references available
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Product Details anti-ICOS Antibody

Target Details ICOS Application Details Handling References for anti-ICOS Antibody (ABIN2660067) Images
Cross-Reactivity Rhesus Monkey, Pig (Porcine)
Purification The antibody was purified by affinity chromatography and conjugated with PerCP/Cy5.5 under optimal conditions. The solution is free of unconjugated PerCP/Cy5.5 and unconjugated antibody.
Clone C398-4A
Isotype IgG

Target Details ICOS

Product Details anti-ICOS Antibody Application Details Handling References for anti-ICOS Antibody (ABIN2660067) Images back to top
Antigen
Alternative Name CD278 (ICOS Antibody Abstract)
Background ICOS, also known as inducible costimulatory molecule and H4, is a 47-57 kD protein. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development.
Pathways TCR Signaling

Application Details

Product Details anti-ICOS Antibody Target Details ICOS Handling References for anti-ICOS Antibody (ABIN2660067) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-ICOS Antibody Target Details ICOS Application Details References for anti-ICOS Antibody (ABIN2660067) Images back to top
Concentration 0.2 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-ICOS Antibody (ABIN2660067)

Product Details anti-ICOS Antibody Target Details ICOS Application Details Handling Images back to top
Background publications

Jie, Liang, Hou, Dong, Iwakura, Soong, Cong, Sun: "Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 7, pp. 3289-300, 2014

Hasegawa, Fujimoto, Matsushita, Hamaguchi, Takehara: "Augmented ICOS expression in patients with early diffuse cutaneous systemic sclerosis." in: Rheumatology (Oxford, England), Vol. 52, Issue 2, pp. 242-51, 2013

Arimura, Shiroki, Kuwahara, Kato, Dianzani, Uchiyama, Yagi: "Akt is a neutral amplifier for Th cell differentiation." in: The Journal of biological chemistry, Vol. 279, Issue 12, pp. 11408-16, 2004

Yagi, Arimura, Dianzani, Uede, Okamoto, Uchiyama: "Regulatory roles of IL-2 and IL-4 in H4/inducible costimulator expression on activated CD4+ T cells during Th cell development." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 2, pp. 783-94, 2003

Arimura, Kato, Dianzani, Okamoto, Kamekura, Buonfiglio, Miyoshi-Akiyama, Uchiyama, Yagi: "A co-stimulatory molecule on activated T cells, H4/ICOS, delivers specific signals in T(h) cells and regulates their responses." in: International immunology, Vol. 14, Issue 6, pp. 555-66, 2002

Buonfiglio, Bragardo, Redoglia, Vaschetto, Bottarel, Bonissoni, Bensi, Mezzatesta, Janeway Jr, Dianzani: "The T cell activation molecule H4 and the CD28-like molecule ICOS are identical." in: European journal of immunology, Vol. 30, Issue 12, pp. 3463-7, 2001

Coyle, Lehar, Lloyd, Tian, Delaney, Manning, Nguyen, Burwell, Schneider, Gonzalo, Gosselin, Owen, Rudd, Gutierrez-Ramos: "The CD28-related molecule ICOS is required for effective T cell-dependent immune responses." in: Immunity, Vol. 13, Issue 1, pp. 95-105, 2000

Hutloff, Dittrich, Beier, Eljaschewitsch, Kraft, Anagnostopoulos, Kroczek: "ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28." in: Nature, Vol. 397, Issue 6716, pp. 263-6, 1999

Redoglia, Dianzani, Rojo, Portolés, Bragardo, Wolff, Buonfiglio, Bonissoni, Janeway: "Characterization of H4: a mouse T lymphocyte activation molecule functionally associated with the CD3/T cell receptor." in: European journal of immunology, Vol. 26, Issue 11, pp. 2781-9, 1997

Images

Product Details anti-ICOS Antibody Target Details ICOS Application Details Handling References for anti-ICOS Antibody (ABIN2660067) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-ICOS antibody (Inducible T-Cell Co-Stimulator)  (PerCP-Cy5.5) (ABIN2660067) anti-Inducible T-Cell Co-Stimulator (ICOS) antibody (PerCP-Cy5.5)