|Application / Reactivity||Mouse (Murine)|
|Activation (Act)||2 Antibodies|
|Blocking Reagent (BR)||3 Antibodies|
|ELISA (Capture)||1 Antibodies|
|ELISA (Detection)||4 Antibodies|
|Flow Cytometry (FACS)||34 Antibodies|
|Immunocytochemistry (ICC)||1 Antibodies|
|Immunofluorescence (IF)||2 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||8 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||4 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||5 Antibodies|
|Immunoprecipitation (IP)||5 Antibodies|
|Intracellular Flow Cytometry (ICFC)||4 Antibodies|
|Mass Cytometry (CyTOF)||1 Antibodies|
|Western Blotting (WB)||9 Antibodies|
|Antigen||Inducible T-Cell Co-Stimulator (ICOS) Antibodies|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This ICOS antibody is conjugated to PE-Cy5 Alternatives|
ELISA (Capture), Mass Cytometry (CyTOF)
|6 references available|
|Supplier||Log in to see|
Product Details anti-ICOS AntibodyTarget Details ICOS Application Details Handling References for anti-ICOS Antibody (ABIN2658951) Images
|Purification||The antibody was purified by affinity chromatography, and conjugated with PE/Cy5 under optimal conditions. The solution is free of unconjugated PE/Cy5 and unconjugated antibody.|
Target Details ICOSProduct Details anti-ICOS Antibody Application Details Handling References for anti-ICOS Antibody (ABIN2658951) Images back to top
|Alternative Name||CD278 (ICOS Antibody Abstract)|
|Background||CD278 is a 47-57 kD protein, also known as inducible costimulatory molecule (ICOS), or H4. This protein is homologous to the CD28/CTLA-4 proteins. It forms homodimers and is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS has been shown to be involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. It has also been shown to be involved in airway tolerance and the downregulation of pulmonary inflammation.|
Application DetailsProduct Details anti-ICOS Antibody Target Details ICOS Handling References for anti-ICOS Antibody (ABIN2658951) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-ICOS Antibody Target Details ICOS Application Details References for anti-ICOS Antibody (ABIN2658951) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Protect from prolonged exposure to light. Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-ICOS Antibody (ABIN2658951)Product Details anti-ICOS Antibody Target Details ICOS Application Details Handling Images back to top
Beus, Hashmi, Selvaraj et al.: "Heterologous immunity triggered by a single, latent virus in Mus musculus: combined costimulation- and adhesion- blockade decrease rejection." in: PLoS ONE, Vol. 8, Issue 8, pp. e71221, 2013 (PubMed).
Rudd, Schneider: "Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling." in: Nature reviews. Immunology, Vol. 3, Issue 7, pp. 544-56, 2003 (PubMed).
Mak, Shahinian, Yoshinaga et al.: "Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses." in: Nature immunology, Vol. 4, Issue 8, pp. 765-72, 2003 (PubMed).
Walker, Wiggett, Gaspal et al.: "Established T cell-driven germinal center B cell proliferation is independent of CD28 signaling but is tightly regulated through CTLA-4." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 1, pp. 91-8, 2002 (PubMed).
Dong, Juedes, Temann et al.: "ICOS co-stimulatory receptor is essential for T-cell activation and function." in: Nature, Vol. 409, Issue 6816, pp. 97-101, 2001 (PubMed).
McAdam, Chang, Lumelsky et al.: "Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 9, pp. 5035-40, 2000 (PubMed).
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